Issue 34, 2022

Cytotoxic effects of halogenated tin phosphinoyldithioformate complexes against several cancer cell lines

Abstract

Organotin complexes are studied as promising alternatives to the anticancer drug cisplatin. We report two monoorganotin(IV) complexes based on a dibenzyl phosphinoyldithioformate (H-DBPTF) ligand, containing either bromide (Sn-DBPTF-1) or chloride (Sn-DBPTF-2) anions. The complexes were characterized by standard analytical techniques and the structural details of these complexes were elucidated by single crystal X-ray diffraction. Sn-DBPTF-1 was cytotoxic at IC50 <10 μg mL−1 against cancer cell lines A549 (lung cancer), Aspc-1 (pancreatic cancer), OVCAR-3 (ovarian cancer), T-47D (breast cancer) and HCT116 (colon cancer), and breast epithelial stem cell line D492. The non-tumorigenic breast epithelial cell line MCF-10 was less sensitive at IC50 = 22 μg mL−1. Sn-DBPTF-2 had limited cytotoxic effect at IC50 13–37 μg mL−1. Sn-DBPTF-1 induced apoptosis and double-strand DNA breaks. Cell cycle arrest in G2 occurred in HCT116 and accumulation in G1 in Aspc-1. The results indicate that the basic effect of Sn-DBPTF-1 is to induce DNA damage, leading to apoptosis and cell cycle arrest depending on the cell line.

Graphical abstract: Cytotoxic effects of halogenated tin phosphinoyldithioformate complexes against several cancer cell lines

Supplementary files

Article information

Article type
Paper
Submitted
11 apr 2022
Accepted
12 aug 2022
First published
15 aug 2022

Dalton Trans., 2022,51, 13119-13128

Cytotoxic effects of halogenated tin phosphinoyldithioformate complexes against several cancer cell lines

M. Balogová, S. Sharma, P. Cherek, S. N. Ólafsson, S. Jónsdóttir, H. M. Ögmundsdóttir and K. K. Damodaran, Dalton Trans., 2022, 51, 13119 DOI: 10.1039/D2DT01127A

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