Issue 7, 2022

“Writing biochips”: high-resolution droplet-to-droplet manufacturing of analytical platforms

Abstract

The development of high-resolution molecular printing allows the engineering of analytical platforms enabling applications at the interface between chemistry and biology, i.e. in biosensing, electronics, single-cell biology, and point-of-care diagnostics. Their successful implementation stems from the combination of large area printing at resolutions from sub-100 nm up to macroscale, whilst controlling the composition and volume of the ink, and reconfiguring the deposition features in due course. Similar to handwriting pens, the engineering of continuous writing systems tackles the issue of the tedious ink replenishment between different printing steps. To this aim, this review article provides an unprecedented analysis of the latest continuous printing methods for bioanalytical chemistry, focusing on ink deposition systems based on specific sets of technologies that have been developed to this aim, namely nanofountain probes, microcantilever spotting, capillary-based polymer pens and continuous 3D printing. Each approach will be discussed revealing the most important applications in the fields of biosensors, lab-on-chips and diagnostics.

Graphical abstract: “Writing biochips”: high-resolution droplet-to-droplet manufacturing of analytical platforms

Article information

Article type
Critical Review
Submitted
20 dec 2021
Accepted
01 mar 2022
First published
02 mar 2022

Analyst, 2022,147, 1294-1312

“Writing biochips”: high-resolution droplet-to-droplet manufacturing of analytical platforms

G. Arrabito, D. Gulli, C. Alfano and B. Pignataro, Analyst, 2022, 147, 1294 DOI: 10.1039/D1AN02295D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements