Issue 7, 2019

Temperature-induced large amplitude conformational change in the complex of oxatub[4]arene revealed via rotaxane synthesis

Abstract

Elevated temperature usually plays a destructive role in supramolecular complexes. At higher temperature, folded proteins tend to unfold and supramolecular assemblies tend to disassemble. In contrast, histidine kinases are able to perform a different function at higher temperature. This results from temperature-induced large amplitude conformational changes. However, similar phenomena have rarely been reported for synthetic receptors. Herein, we report that the conformationally adaptive oxatub[4]arene is able to show a conformational response to temperature change in the presence of an appropriate guest. By employing rotaxane synthesis, the host's conformation in the complex at different temperatures can be fixed. The resulting rotaxanes with different host conformations have been carefully characterized by using 2D NMR spectroscopy, mass spectrometry, and X-ray single crystallography.

Graphical abstract: Temperature-induced large amplitude conformational change in the complex of oxatub[4]arene revealed via rotaxane synthesis

Supplementary files

Article information

Article type
Research Article
Submitted
30 jan 2019
Accepted
19 feb 2019
First published
21 feb 2019

Org. Chem. Front., 2019,6, 1027-1031

Temperature-induced large amplitude conformational change in the complex of oxatub[4]arene revealed via rotaxane synthesis

D. Li, L. Yang, H. Chai, F. Jia, H. Ke and W. Jiang, Org. Chem. Front., 2019, 6, 1027 DOI: 10.1039/C9QO00159J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements