Issue 26, 2019

Ferritin variants: inspirations for rationally designing protein nanocarriers

Abstract

Ferritin, a natural iron storage protein, is endowed with a unique structure, the ability to self-assemble and excellent physicochemical properties. Beyond these, genetic manipulation can easily tune the structure and functions of ferritin nanocages, which further expands the biomedical applications of ferritin. Here, we focus on human H-ferritin, a recently discovered ligand of transferrin receptor 1, to review its derived variants and related structures and properties. We hope this review will provide new insights into how to rationally design versatile protein cage nanocarriers for effective disease treatment.

Graphical abstract: Ferritin variants: inspirations for rationally designing protein nanocarriers

Article information

Article type
Minireview
Submitted
05 maj 2019
Accepted
07 jun 2019
First published
07 jun 2019

Nanoscale, 2019,11, 12449-12459

Ferritin variants: inspirations for rationally designing protein nanocarriers

Y. Jin, J. He, K. Fan and X. Yan, Nanoscale, 2019, 11, 12449 DOI: 10.1039/C9NR03823J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements