Issue 32, 2017

Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine

Abstract

The promising biomedical applications of graphene oxide (GO) have quickly catalyzed a generation of various GO-based functional composites with desirable nanostructures and composites to satisfy the specific biomedical applications of GO-based nanosystems. This comprehensive review summarizes and discusses the very recent developments in rational design, chemical fabrication and versatile biomedical applications of GO-based functional composites, including metal oxide–GO, metal–GO, fluorescent nanoparticles–GO, silica–GO, polymer–GO and other specific GO-based composite nanosystems. The integration of multi-components with GO is also discussed. Their versatile theranostic applications include diagnostic imaging-guided therapy (photothermal therapy, photodynamic therapy and chemotherapy), biosensing-based tumor detection, and synergistic therapy. The biocompatibility and biosafety of these promising GO-based nanocomposites are also briefly mentioned. Finally, the unresolved critical issues and challenges facing the design/fabrication/application of these unique GO-based functional nanocomposites are proposed to further promote their clinical translation. The unique multi-composition, nanostructure and unique theranostic performance of GO-based composites are highly expected to pave a new way for the development of highly efficient theranostic protocols/approaches for precise personalized biomedicine to benefit human health.

Graphical abstract: Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine

Article information

Article type
Review Article
Submitted
11 mar 2017
Accepted
27 apr 2017
First published
27 apr 2017

J. Mater. Chem. B, 2017,5, 6451-6470

Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine

Y. Zhou, X. Jing and Y. Chen, J. Mater. Chem. B, 2017, 5, 6451 DOI: 10.1039/C7TB00680B

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