Issue 31, 2011

Automated solid phase synthesis of teichoic acids

Abstract

This communication describes the first automated solid phase synthesis of teichoic acids (TAs) and the preparation by this method of a number of well-defined TA structures, which were probed for their antigenicity. An opsonophagocytic killing assay revealed a clear TA-length–activity relationship and indicated a promising candidate for future vaccine development.

Graphical abstract: Automated solid phase synthesis of teichoic acids

Supplementary files

Article information

Article type
Communication
Submitted
27 maj 2011
Accepted
27 jun 2011
First published
06 jul 2011

Chem. Commun., 2011,47, 8961-8963

Automated solid phase synthesis of teichoic acids

W. F. J. Hogendorf, N. Meeuwenoord, H. S. Overkleeft, D. V. Filippov, D. Laverde, A. Kropec, J. Huebner, G. A. Van der Marel and J. D. C. Codée, Chem. Commun., 2011, 47, 8961 DOI: 10.1039/C1CC13132J

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