Themed collection 2024 Chemical Science Covers
Front cover
Chem. Sci., 2024,15, 8593-8594
https://doi.org/10.1039/D4SC90108H
Outer-sphere effects on the O2 sensitivity, catalytic bias and catalytic reversibility of hydrogenases
The comparison of homologous hydrogenases, in which the same inorganic active site is surrounded by a variable protein matrix, has demonstrated that residues that are remote from the active site may have a great influence on catalytic properties.
Chem. Sci., 2024,15, 5418-5433
https://doi.org/10.1039/D4SC00691G
Connecting chemical worlds for a sustainable future
While chemistry has a role as the central science, other sciences are also central to solving the problems that lie ahead. To be more effective in this endeavor, we need to connect disciplines and break down the silos that artificially separate them.
Chem. Sci., 2024,15, 5056-5060
https://doi.org/10.1039/D3SC06815C
Bioorthogonal chemistry of polyoxometalates – challenges and prospects
Advances in bioorthogonal polyoxometalate (POM) chemistry will open exciting opportunities for the controlled use of stimuli-responsive POM-based organic–inorganic nanoassemblies in biomedical applications as well as catalysis and electronics.
Chem. Sci., 2024,15, 4202-4221
https://doi.org/10.1039/D3SC06284H
Enzymatic and synthetic regulation of polypeptide folding
This perspective focuses on the latest understanding of the folding-promotion mechanisms by chaperones and oxidoreductases and recent progress in the development of chemical mimics that possess activities comparable to enzymes.
Chem. Sci., 2024,15, 2282-2299
https://doi.org/10.1039/D3SC05781J
Challenges in the design and synthesis of self-assembling molecules as selective contacts in perovskite solar cells
We summarize the challenges to design and synthesize self-assembled molecules, discussing their synthetic routes and structural features in relationship to the efficiency of perovskite-based solar cells where they are applied as selective contacts.
Chem. Sci., 2024,15, 1534-1556
https://doi.org/10.1039/D3SC04668K
The supersaturation perspective on the amyloid hypothesis
The current amyloid hypothesis does not capture the full complexity of Aβ aggregation. Here we lay out a supersaturation framework to better understand the molecular mechanism of Alzheimer’s disease and to develop more effective treatment strategies.
Chem. Sci., 2024,15, 46-54
https://doi.org/10.1039/D3SC03981A
Adamantane-type clusters: compounds with a ubiquitous architecture but a wide variety of compositions and unexpected materials properties
Adamantane-type clusters exhibit a huge diversity of chemical compositions, structural details, and resulting properties.
Chem. Sci., 2024,15, 9438-9509
https://doi.org/10.1039/D4SC01136H
The status and challenging perspectives of 3D-printed micro-batteries
Recent advances and present status of 3D-printed micro-batteries with respect to the connection between printable materials and printing techniques, as well as the rational design considerations are summarized.
Chem. Sci., 2024,15, 5451-5481
https://doi.org/10.1039/D3SC06999K
Non-destructive real-time monitoring and investigation of the self-assembly process using fluorescent probes
Fluorescent probes for detecting complex environments in vivo play an important role in self-assembly in vitro.
Chem. Sci., 2024,15, 3800-3830
https://doi.org/10.1039/D3SC06527H
Water-stable metal–organic frameworks (MOFs): rational construction and carbon dioxide capture
This review highlights the design and synthesis of water-stable MOFs, as well as their applications in carbon capture.
Chem. Sci., 2024,15, 1570-1610
https://doi.org/10.1039/D3SC06076D
Hollow carbon-based materials for electrocatalytic and thermocatalytic CO2 conversion
This review covers the syntheses, functionalization strategies of hollow carbon-based materials, as well as their applications in electrocatalytic and thermocatalytic CO2 conversion.
Chem. Sci., 2024,15, 854-878
https://doi.org/10.1039/D3SC05026B
Preparation of intrinsically fragile bent crystals
A methylated flufenamic acid gave two different polymorphs, mechanically deformable α form and fragile γ form. We successfully obtained the “intrinsically brittle” bent γ crystal by vapor-induced phase transition from the bent α crystal.
Chem. Sci., 2024,15, 12258-12263
https://doi.org/10.1039/D4SC02918F
Rh(III)-catalyzed building up of used heterocyclic cations: facile access to white-light-emitting materials
This work unlocks an opportunity to rapidly construct fused heterocyclic cations for efficient screening of single-molecular white-light-emitting materials and pure red-light-emitting materials.
Chem. Sci., 2024,15, 12270-12276
https://doi.org/10.1039/D4SC02188F
Step-induced double-row pattern of interfacial water on rutile TiO2(110) under electrochemical conditions
Unraveling the interfacial structure on aqueous stepped TiO2 surface by combing electrochemical scanning tunneling microscopy and machine learning accelerated molecular dynamics.
Chem. Sci., 2024,15, 12264-12269
https://doi.org/10.1039/D4SC01952K
Controlled nanocrystallization of gold nanoclusters within surfactant envelopes: enhancing aggregation-induced emission in solution
Sphere-shaped amorphous aggregates of Au8 clusters entrapped within SDS nanoenvelopes are transformed into rhombic single nanocrystals upon simple sonication in solution, where the aggregation-induced emission (AIE) from Au8 is notably enhanced.
Chem. Sci., 2024,15, 11775-11782
https://doi.org/10.1039/D4SC02834A
Molecular “backbone surgery” of electron-deficient heteroarenes based on dithienopyrrolobenzothiadiazole: conformation-dependent crystal structures and charge transport properties
A conformation engineering strategy is proposed to manipulate the crystal structure of electron deficient heteroarenes for superior n-type organic semiconductors with an electron mobility of 3.5 cm2 V−1 s−1.
Chem. Sci., 2024,15, 11761-11774
https://doi.org/10.1039/D4SC02794A
A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements
Covalent DFOB-DOTA dual chelator (‘D2’) binds 89Zr (DFOB) and 177Lu (DOTA) regio-selectively enabling 89Zr–177Lu pairing as a novel cancer-targeting theranostic.
Chem. Sci., 2024,15, 11748-11760
https://doi.org/10.1039/D4SC02851A
Helically twisted nanoribbons via stereospecific annulative π-extension reaction employing [7]helicene as a molecular wrench
Enantiopure [7]helicenes were utilized as molecular wrenches at the terminal K-regions of the conjugated pyrene nanoribbon to achieve a 99.9% conformational population of a single-handed helical ribbon with an end-to-end twist of 171°.
Chem. Sci., 2024,15, 11737-11747
https://doi.org/10.1039/D4SC01814A
PYTA: a universal chelator for advancing the theranostic palette of nuclear medicine
PYTA is demonstrated to rapidly and stably complex 225Ac, 177Lu, 111In, and 44Sc, a “superfecta” of complementary but chemically distinct radiometals for targeted theranostic applications.
Chem. Sci., 2024,15, 11279-11286
https://doi.org/10.1039/D3SC06854D
Synthesis of polyoxothiometalates through site-selective post-editing sulfurization of polyoxometalates
This work presents a direct site-selective oxygen–sulfur substitution method that enables transforming polyoxometalates [XW12O40]4− (X = Si, Ge) to Keggin-type polyoxothiometalates [XW12O28S12]4− using sulfurizing reagents in an organic solvent.
Chem. Sci., 2024,15, 11267-11271
https://doi.org/10.1039/D4SC02912G
A pair of conjoined trinuclear sub-frameworks in a pentanuclear double-cavity discrete coordination cage
Multi-cavity discrete coordination cages (MCDCC) are prepared by mixing Pd(II) with designer bis- and tris-monodentate ligands in a 5 : 4 : 4 ratio. Two trinuclear sub-frameworks are conjoined in the molecular architecture of the ensuing MCDCC.
Chem. Sci., 2024,15, 11287-11301
https://doi.org/10.1039/D4SC01078G
Macrophage-engaging peptidic bispecific antibodies (pBsAbs) for immunotherapy via a facile bioconjugation strategy
A novel peptidic bispecific antibody (pBsAb) is developed by integrating EGFR-binding cyclic peptide with an anti-SIRP-α antibody, promotes cancer cells recognition, suppresses "don't eat me" signal, and enhances phagocytosis and tumour infiltration.
Chem. Sci., 2024,15, 11272-11278
https://doi.org/10.1039/D4SC00851K
Spontaneous ligand loss by soft landed [Ni(bpy)3]2+ ions on perfluorinated self-assembled monolayer surfaces
[Ni(bpy)3]2+ soft landed on surfaces dissociates spontaneously. Codeposition of stable anions with cations enables preservation of the structure of [Ni(bpy)3]2+.
Chem. Sci., 2024,15, 10770-10783
https://doi.org/10.1039/D4SC02527J
A water-soluble, cell-permeable Mn(II) sensor enables visualization of manganese dynamics in live mammalian cells
A water-soluble, cell-permeable, turn-on Mn2+ sensor visualizes Mn2+ dynamics live and provides an estimate for endogenous labile Mn2+ in a living mammalian cell.
Chem. Sci., 2024,15, 10753-10769
https://doi.org/10.1039/D4SC00907J
Pathway-dependent supramolecular polymerization by planarity breaking
We introduce planarity breaking as a new design strategy for controlled supramolecular polymerization.
Chem. Sci., 2024,15, 10745-10752
https://doi.org/10.1039/D4SC02499K
Fast, efficient, narrowband room-temperature phosphorescence from metal-free 1,2-diketones: rational design and the mechanism
Fast room-temperature phosphorescence with high quantum yields up to 38% in solution from metal-free organic 1,2-diketones is reported, along with the mechanism and molecular design principles governing the fast phosphorescence.
Chem. Sci., 2024,15, 10784-10793
https://doi.org/10.1039/D4SC02841D
Unlocking the chemical environment of nitrogen in perovskite-type oxides
Advanced vacuum temperature-programmed desorption up to 1600 °C can be used for precise quantification and chemical speciation of nitrogen species in perovskite-type oxides at the bulk level, complementing the surface-sensitive XPS techniques.
Chem. Sci., 2024,15, 10350-10358
https://doi.org/10.1039/D4SC01850H
Oxidatively-induced C(sp3)–C(sp3) bond formation at a tucked-in iron(III) complex
Carbon–carbon (C–C) bond formation is a cornerstone of synthetic chemistry, relying on routes such as transition-metal mediated cross-coupling for the introduction of new carbon-based functionality.
Chem. Sci., 2024,15, 10359-10365
https://doi.org/10.1039/D4SC03292F
Structure-aware dual-target drug design through collaborative learning of pharmacophore combination and molecular simulation
AIxFuse learns to fuse pharmacophores to generate potential dual-target drugs through collaborative learning by Monte Carlo tree search and machine learning.
Chem. Sci., 2024,15, 10366-10380
https://doi.org/10.1039/D4SC00094C
From cubane-assembled Mn-oxo clusters to monodispersed manganese oxide colloidal nanocrystals
The high nuclearity cubane-assembled Mn-oxo clusters serve as effective precursors for the preparation of monodispersed Mn3O4 nanocrystals through the colloidal chemistry approach.
Chem. Sci., 2024,15, 10381-10391
https://doi.org/10.1039/D4SC01451K
Comparing organic and metallo-organic hydrazone molecular cages as potential carriers for doxorubicin delivery
A comparative study between a metallo-organic cage and a fully organic analogous system shows that the fully organic molecular cage has a suitable stability and doxorubicin affinity for in vitro anticancer drug delivery.
Chem. Sci., 2024,15, 10010-10017
https://doi.org/10.1039/D4SC02294G
Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery
High glutathione production is known to be one of the defense mechanisms by which many cancer cells survive elevated oxidative stress.
Chem. Sci., 2024,15, 9987-10001
https://doi.org/10.1039/D4SC01625D
Computational analysis of R–X oxidative addition to Pd nanoparticles
A computational elucidation of the mechanism of R–X oxidative addition to Pd nanoparticles revealed high activity at the edges of nanoparticles and identified key intermediates before and after oxidative addition.
Chem. Sci., 2024,15, 9977-9986
https://doi.org/10.1039/D4SC00628C
Site-selective S-gem-difluoroallylation of unprotected peptides with 3,3-difluoroallyl sulfonium salts
Bench-stable 3,3-difluoroallyl sulfonium salts proved to be versatile fluoroalkylating reagents for site-selective S-gem-difluoroallylation of cysteine residues in unprotected peptides. The newly added functional groups are poised for ligation.
Chem. Sci., 2024,15, 10002-10009
https://doi.org/10.1039/D4SC02681K
Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein
Chemical regulation of glycan synthesis at the targeted cancer cell surface in mice leading to significant anticancer effects without side effects.
Chem. Sci., 2024,15, 9566-9573
https://doi.org/10.1039/D4SC00969J
Halo-perfluoroalkoxylation of gem-difluoroalkenes with short-lived alkali metal perfluoroalkoxides in triglyme
The synthesis of long-chain perfluoroalkyl ethers remains a challenge. The stabilization of longer-chain perfluoroalkoxides with triglyme-encapsulated potassium ions enabled the synthesis of bis(α,α-difluoro)ethers with gem-difluoroalkenes.
Chem. Sci., 2024,15, 9574-9581
https://doi.org/10.1039/D4SC02084G
Rapid solar-driven atmospheric water-harvesting with MAF-4-derived nitrogen-doped nanoporous carbon
A MOF-derived nanoporous carbon (NPCMAF-4-800) with multiple N-doped sites, considerable porous characteristics and inherent photothermal properties demonstrated a superior water-production rate under a relatively arid climate.
Chem. Sci., 2024,15, 9557-9565
https://doi.org/10.1039/D4SC01802H
Facile synthesis and characterization of aza-bridged all-benzenoid quinoidal figure-eight and cage molecules
Fully π-conjugated figure-eight (FEM) and cage (CATPA and CACz) molecules were synthesized via reversible intermolecular Friedel–Crafts alkylation. They could be oxidized to cationic species and showed intramolecular dynamics and AIE behavior.
Chem. Sci., 2024,15, 9087-9095
https://doi.org/10.1039/D3SC02707D
Engineered π⋯π interactions favour supramolecular dimers X@[FeL3]2 (X = Cl, Br, I): solid state and solution structure
The engineered supramolecular recognition of coordination complexes achieved by ligand design is shown in the solid state and in solution via X-ray diffraction and paramagnetic H-NMR spectroscopy.
Chem. Sci., 2024,15, 9047-9053
https://doi.org/10.1039/D4SC01365D
Re-pairing DNA: binding of a ruthenium phi complex to a double mismatch
The complex [Ru(phen)2phi]2+ creates a bulge site when crystallised with a DNA dodecamer which includes the Pribnow box sequence.
Chem. Sci., 2024,15, 9096-9103
https://doi.org/10.1039/D4SC01448K
An anthropocene-framed transdisciplinary dialog at the chemistry-energy nexus
Five molecules at the energy-chemistry nexus, their position in the planetary boundary framework and Anthropocene-spurred interdisciplinary connections between chemistry, social sciences, and humanities to help define sustainability-driven research.
Chem. Sci., 2024,15, 9054-9086
https://doi.org/10.1039/D4SC00099D
Exceptional three- to six-photon absorption at organometallic dendrimers
Metallodendrimers exhibit two- to six-photon absorption at key spectral regions (near-infrared I, II, and III). Structure-nonlinear absorption studies have defined the key molecular components contributing to the exceptional performance.
Chem. Sci., 2024,15, 8731-8739
https://doi.org/10.1039/D4SC01127A
Neutral inverse-sandwich rare-earth metal complexes of the benzene tetraanion
Neutral inverse-sandwich rare-earth metal complexes of the parent benzene tetraanion with an [M3+–(C6H6)4−–M3+] core electronic structure were synthesized and characterized. They behave as a four-electron reductant to reduce unsaturated substrates.
Chem. Sci., 2024,15, 8740-8749
https://doi.org/10.1039/D4SC02491E
Tricyclononenes and tricyclononadienes as efficient monomers for controlled ROMP: understanding structure–propagation rate relationships and enabling facile post-polymerization modification
A tricyclononene and tricyclononadiene monomer library is studied experimentally and computationally to deepen understanding of structure propagation rate relationships in ROMP. A novel poly(tricyclononadiene) post-ROMP functionalization is explored.
Chem. Sci., 2024,15, 8334-8345
https://doi.org/10.1039/D4SC01986E
A post-synthetic modification strategy for enhancing Pt adsorption efficiency in MOF/polymer composites
A post-synthetic modification strategy was developed to graft metal chelating thiols to polydopamine inside Fe-BTC. X-ray absorption spectroscopy revealed interesting redox properties of the composite that help extract and reduce Pt(IV) from liquid.
Chem. Sci., 2024,15, 8323-8333
https://doi.org/10.1039/D4SC00174E
Clinically used drug arsenic trioxide targets XIAP and overcomes apoptosis resistance in an organoid-based preclinical cancer model
Drug resistance in tumor cells remains a persistent clinical challenge in the pursuit of effective anticancer therapy. Herein, we repurpose clinically used drug arsenic trioxide to target XIAP and overcome cisplatin drug resistance in tumors.
Chem. Sci., 2024,15, 8311-8322
https://doi.org/10.1039/D4SC01294A
Metallaaromaticity involving a d0 early transition metal centre: synthesis, structure, and aromaticity of tantallapyridinazirine complexes
Though late transition metal aromatic metallabenzenes and related heteroatom-containing analogues have been well studied, the corresponding aromatic early transition metal complexes remain elusive.
Chem. Sci., 2024,15, 7943-7948
https://doi.org/10.1039/D4SC02629B
Toward robust lithium–sulfur batteries via advancing Li2S deposition
The GeS2-MoS2/rGO heterostructure is designed as a sulfur host to facilitate the conversion of polysulfides and advance the deposition of Li2S synergistically by strengthening the hybrid current during cycling.
Chem. Sci., 2024,15, 7949-7964
https://doi.org/10.1039/D4SC02420F
Materials discovery with extreme properties via reinforcement learning-guided combinatorial chemistry
A reinforcement-learned policy that sequentially selects suitable molecular fragments to design molecules that meet targeted properties was proposed. The proposed methodology can discover materials with properties beyond the known property range.
Chem. Sci., 2024,15, 7908-7925
https://doi.org/10.1039/D3SC05281H
DiffBindFR: an SE(3) equivariant network for flexible protein–ligand docking
DiffBindFR, a diffusion model based flexible full-atom protein–ligand docking tool, demonstrates its superior docking and side-chain refinement accuracy with reliable physical plausibility.
Chem. Sci., 2024,15, 7926-7942
https://doi.org/10.1039/D3SC06803J
1,5-Hydrogen atom transfer of α-iminyl radical cations: a new platform for relay annulation for pyridine derivatives and axially chiral heterobiaryls
A new 1,5-hydrogen atom transfer mode of α-iminyl radical cations has been explored, which enables the efficient construction of fused pyridine and axially chiral heterobiaryl scaffolds via relay annulations.
Chem. Sci., 2024,15, 7502-7514
https://doi.org/10.1039/D4SC01858C
Universal cell membrane camouflaged nano-prodrugs with right-side-out orientation adapting for positive pathological vascular remodeling in atherosclerosis
The preparation of right-side-out-orientated coupling-driven ROS-sensitive nanoparticles on the inner leaflet of the cell membrane for positively regulating cell phenotypic conversion in atherosclerosis.
Chem. Sci., 2024,15, 7524-7544
https://doi.org/10.1039/D4SC00761A
Influence of the substitution position on spin communication in photoexcited perylene–nitroxide dyads
Photoexcited chromophore–radical dyads are suitable for applications in molecular spintronics. We show that the position of attachment of the radical to the chromophore can be used as a means to tune their optical and magnetic properties.
Chem. Sci., 2024,15, 7515-7523
https://doi.org/10.1039/D4SC00328D
A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2
How a peptoid binds to a protein was revealed by a co-crystal structure and systematic physicochemical studies.
Chem. Sci., 2024,15, 7051-7060
https://doi.org/10.1039/D4SC01540A
Therapeutic coordination polymers: tailoring drug release through metal–ligand interactions
Tailor-made drug release materials based on non-porous therapeutic coordination polymers in which drug-release rates can be primarily tuned by the strength of metal–ligand interactions and finely tuned by altering the length of bis-imidazole linkers.
Chem. Sci., 2024,15, 7041-7050
https://doi.org/10.1039/D4SC00732H
Surface proton hopping conduction mechanism dominant polymer electrolytes created by self-assembly of bicontinuous cubic liquid crystals
Ultrafast surface proton hopping conduction was achieved in a gyroid nanostructured polymer films having a 3D continuous interface where sulfonate groups are aligned densely and periodically.
Chem. Sci., 2024,15, 7034-7040
https://doi.org/10.1039/D4SC01211A
Precise analyses of photoelectrochemical reactions on particulate Zn0.25Cd0.75Se photoanodes in nonaqueous electrolytes using Ru bipyridyl complexes as a probe
Energy levels of interfacial recombination centres and photocorrosion potential for Zn0.25Cd0.75Se particulate photoanodes in nonaqueous electrolytes containing various Ru complexes are elucidated. Redox reaction of Ru complexes can serve as a probe.
Chem. Sci., 2024,15, 6679-6689
https://doi.org/10.1039/D4SC00511B
Ultrafast photogeneration of a metal–organic nitrene from 1,1′-diazidoferrocene
A bent azide intermediate is key to form 1-azido-1′-nitrenoferrocene from 1,1′-diazidoferrocene, as shown with UV-pump–mid-IR-probe transient absorption spectroscopy and density functional theoryTD-DFT calculations including spin–orbit coupling.
Chem. Sci., 2024,15, 6707-6715
https://doi.org/10.1039/D4SC00883A
Understanding Cu(I) local environments in MOFs via63/65Cu NMR spectroscopy
63/65Cu solid-state NMR spectroscopy provides a wealth of information regarding the local geometry and bonding at Cu(I) in metal–organic frameworks. This approach is also applicable when systems contain Cu(II) centers or at lower magnetic fields.
Chem. Sci., 2024,15, 6690-6706
https://doi.org/10.1039/D4SC00782D
High-throughput single-cell mass spectrometry enables metabolic network analysis by resolving phospholipid CC isomers
A high-throughput single-cell MS platform that can perform both lipid profiling and unsaturated lipid CC location isomer resolution analysis was developed, which can be effectively used for in-depth structural lipid metabolism network analysis.
Chem. Sci., 2024,15, 6314-6320
https://doi.org/10.1039/D3SC06573A
Electronic isomerism in a heterometallic nickel–iron–sulfur cluster models substrate binding and cyanide inhibition of carbon monoxide dehydrogenase
A protein-based model of carbon monoxide dehydrogenase displays distinct X-ray absorption, EPR, and vibrational signatures upon CO and CN− binding that support ligand-dependent electronic rearrangement throughout the nickel–iron–sulfur core.
Chem. Sci., 2024,15, 5916-5928
https://doi.org/10.1039/D4SC00023D
Addition of allyl Grignard to nitriles in air and at room temperature: experimental and computational mechanistic insights in pH-switchable synthesis
Surpassing the tradition, experimental and DFT calculations showed the crucial role of water in the selective synthesis of tetrahydropyridines, aminoketones or enamines via allyl Grignard addition to nitriles, unmatched by dry organic solvents.
Chem. Sci., 2024,15, 5929-5937
https://doi.org/10.1039/D3SC06403D
Critical assessment of interactions between ct-DNA and choline-based magnetic ionic liquids: evidences of compaction
DNA compaction is a critical aspect of gene regulation and has significant implications in the field of medicine. This work focuses on an innovative and alternative compaction method for DNA using choline-based magnetic ionic liquids.
Chem. Sci., 2024,15, 5507-5515
https://doi.org/10.1039/D4SC00004H
Highly selective, reversible water activation by P,N-cooperativity in pyridyl-functionalized phosphinines
Aromatic phosphorus heterocycles react at room temperature highly selectively and reversibly with water by P,N-cooperativity. The aromaticity of such compounds plays an appreciable role in the reversibility of the reaction, supported by NICS calculations.
Chem. Sci., 2024,15, 5496-5506
https://doi.org/10.1039/D3SC05930H
Benchmarking pH-field coupled microkinetic modeling against oxygen reduction in large-scale Fe–azaphthalocyanine catalysts
Molecular Fe azaphthalocyanine catalysts with diverse long-chain “dancing patterns” demonstrate variable oxygen reduction reaction performance for fuel cells, aligning well with our pH-field coupled microkinetic model.
Chem. Sci., 2024,15, 5123-5132
https://doi.org/10.1039/D4SC00473F
Peptide recognition by a synthetic receptor at subnanomolar concentrations
The synthetic receptor cucurbit[8]uril (Q8) binds the N-terminal dipeptide site Lys-Phe with subnanomolar affinity in neutral aqueous buffer.
Chem. Sci., 2024,15, 5133-5142
https://doi.org/10.1039/D4SC01122H
Cross-coupling of organic fluorides with allenes: a silyl-radical-relay pathway for the construction of α-alkynyl-substituted all-carbon quaternary centres
Cross-coupling of organic fluorides with allenes via radical rearrangement to afford all-carbon quaternary centres mediated by silylboronate/potassium tert-butoxide is disclosed.
Chem. Sci., 2024,15, 5113-5122
https://doi.org/10.1039/D3SC06617G
Tunable fluorescent probes for detecting aldehydes in living systems
Introducing 4-amino-3-thiophenol BODIPY “turn on” probe tunable to NIR wavelengths for monitoring aldehydes in tissues and living organoids by forming dihydrobenzothiazole products with aldehydes, exhibiting a remarkable fluorescence increase.
Chem. Sci., 2024,15, 4763-4769
https://doi.org/10.1039/D4SC00391H
Synthetic utility of functionalized alkylsilyl peroxides for Fe-catalyzed and visible-light-promoted radical transformation
α-Keto-, β-acetoxy- and β-amidoalkylsilyl peroxides are prepared from various precursors and utilized for Fe-catalyzed and visible-light-promoted radical functionalization with coupling partners under mild conditions with a broad substrate scope.
Chem. Sci., 2024,15, 4757-4762
https://doi.org/10.1039/D3SC06857A
About this collection
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