A unified strategy to generate acyl radicals from α-imino-oxy acids via selective C–C bond activation is reported. In the presence of a silver catalyst, α-imino-oxy acids could undergo decarboxylation and N–O and C–C bond homolysis to deliver the acyl radicals, which were subsequently captured by N-alkyl-N-aryl-2-(trifluoromethyl)acrylamides to access acylated 3-CF3-2-oxindoles.
Y. Cao, Y. Wei, Y. Hu, D. Liu, M. Liu, J. Wang, C. Li, P. Wang, L. Hu and F. Li, Org. Biomol. Chem., 2025, 23, 5106 DOI: 10.1039/D5OB00262A
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