Themed collection 2025 Nanoscale HOT Article Collection
Advances in Atomic-to-Nanoscale Cr3+ lattice Engineering for Near-Infrared Emitting Ceramic Phosphors
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR04136H
Lithium aluminum titanium phosphate (LATP) composite solid-state electrolytes: progress and prospects for all-solid-state batteries
This review summarizes the research progress of LATP-based polymer composite solid electrolytes (CSEs), providing a reference for future research directions.
Nanoscale, 2025,17, 26642-26657
https://doi.org/10.1039/D5NR03393D
Energy-conversion nano/micromaterial based retinal prostheses for vision restoration
This review focuses on retinal prostheses using energy-conversion nano/micromaterials (photovoltaic, piezoelectric, upconversion, and photothermal), which enable wireless/self-powered operation with advantages like high sensitivity and resolution.
Nanoscale, 2025,17, 26621-26641
https://doi.org/10.1039/D5NR02287H
Layered intercalation ferroelectricity induced by asymmetric ion coordination: a mini-review
The emerging intercalation ferroelectricity may provide significant scientific and technological opportunities.
Nanoscale, 2025,17, 25477-25483
https://doi.org/10.1039/D5NR03854E
Electrode reaction mechanisms in aqueous batteries: a comparative study and perspective on solid–solid versus solid–liquid–solid conversions
This work systematically compares solid–solid and solid–liquid–solid conversion mechanisms in aqueous batteries and provides new insights into designing high-performance aqueous energy storage systems.
Nanoscale, 2025,17, 23273-23287
https://doi.org/10.1039/D5NR03170B
Two-dimensional ferroelectric synaptic devices enabled by diverse coupling mechanisms
Two-dimensional (2D) van der Waals (vdW) ferroelectric (FE) materials have recently emerged as promising candidates for advanced synaptic devices in brain-inspired neuromorphic computing systems.
Nanoscale, 2025,17, 22763-22794
https://doi.org/10.1039/D5NR02639C
Integrating piezoelectric dressings with botanicals as emerging smart dressings for diabetic wound healing
Three aspects that piezoelectric materials promote wound healing are as follows: (A) electrical stimulation promotes tissue repair, (B) piezoelectric catalytic antibacterial action, and (C) drug-loaded piezoelectric dressings.
Nanoscale, 2025,17, 20044-20056
https://doi.org/10.1039/D5NR01797A
The application prospect of metal/metal oxide nanoparticles in the treatment of intervertebral disc degeneration
This review highlights the therapeutic potential of metal-based and metal oxide nanoparticles in IVDD by leveraging their antioxidant, anti-inflammatory, and microenvironment-modulating properties to enhance tissue repair. The ToC was created in BioRender. Zhang, L. (2025) https://BioRender.com/6fzdcqv.
Nanoscale, 2025,17, 15605-15616
https://doi.org/10.1039/D4NR05504G
Biomimetic ion channels with subnanometer sizes for ion sieving: a mini-review
The ion-selective transport property of biological systems has inspired the development of biomimetic ion channels. This mini-review highlights the mechanisms, recent fabrication strategies and applications of biomimetic ion channels.
Nanoscale, 2025,17, 9021-9039
https://doi.org/10.1039/D5NR00758E
Recent advances in multimodal mechanoluminescent sensors enabled by nanostructure design
Multifunctional coupling and signal decoupling achieved through nanostructure and supramolecule design, enable multimodal mechanoluminescent materials to play an increasingly important role in interdisciplinary applications and cutting-edge fields.
Nanoscale, 2025,17, 6414-6426
https://doi.org/10.1039/D4NR04875J
Nanomaterial-mediated ferroptosis as a promising strategy for cancer therapy
Conventional cancer therapies, such as chemotherapy and radiotherapy, often face limitations due to drug resistance, systemic toxicity, and tumor heterogeneity, which significantly limit the therapeutic effect.
Nanoscale, 2025,17, 27066-27084
https://doi.org/10.1039/D5NR03627E
Design and application of proton gradient-based pH-responsive nanomaterials in the tumor microenvironment
The five nanoparticles target the tumor acidic microenvironment through the mechanism of (1) ionizable groups and (2) pH-sensitive chemical bonds.
Nanoscale, 2025,17, 27042-27065
https://doi.org/10.1039/D5NR02990B
Recent advances in nucleic acid nanotechnology-driven artificial transcriptional components
Nucleic acid nanotechnology-based artificial transcriptional components (aTCs) can be integrated into synthetic transcriptional circuits to recognize external signals, process information, and execute decision-based functions.
Nanoscale, 2025,17, 26514-26531
https://doi.org/10.1039/D5NR03210E
Recent advances in aerogel-based triboelectric nanogenerators: working principles, fabrication strategies, performance optimization, and applications
We present a comprehensive review on the principles, construction, performance optimization, and diverse applications of aerogel-based triboelectric nanogenerators. Reproduced with permission (see main article for details).
Nanoscale, 2025,17, 26477-26513
https://doi.org/10.1039/D5NR02327K
Recent advances in carbon nanotube composite films for electromagnetic interference shielding
Optimized CNT composite films deliver exceptional EMI shielding. By integrating conductivity and layered structures, these lightweight, flexible materials are promising for future electronics and aerospace solutions. Images reproduced with permission; full details in paper.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR04085J
Recent advancements in the precise engineering of block copolymer microparticles via confined assembly in emulsion droplets
This review examines key parameters for preparing block copolymer microparticles via 3D emulsion-confined assembly, enabling the design of functional polymeric particles with integrated properties for diverse applications.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR04162G
Recent advances in pH-sensitive clay nanomaterials for enhanced immunotherapy of solid tumors
Restoring physicochemical homeostasis in tumor tissues with functional clay nanomaterials can convert the ‘cold’ immune microenvironment into a ‘hot’ one for enhanced immunotherapy of solid tumors.
Nanoscale, 2025,17, 25964-25974
https://doi.org/10.1039/D5NR02901E
Nanozyme-driven remodeling of the immune microenvironment: from catalytic therapy to precise immune regulation
By mimicking enzymatic activities, nanozymes emerge as versatile platforms to reprogram immune responses, paving the way for next-generation immunotherapy.
Nanoscale, 2025,17, 25947-25963
https://doi.org/10.1039/D5NR03420E
Progress on Perovskite Photodetectors for Optical Communications
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03957F
Boron nitride memristors: from mechanism and device optimization to integrated applications
This review comprehensively introduces the preparation, performance, mechanism and application of BN memristors, making up for the lack of content in this field.
Nanoscale, 2025,17, 24830-24859
https://doi.org/10.1039/D5NR03494A
Hydrogel-based sensors for multimodal health monitoring: from material design to intelligent sensing
Hydrogels, due to their biocompatibility, tunability, and stimulus responsiveness, are promising materials for flexible health monitoring.
Nanoscale, 2025,17, 24805-24829
https://doi.org/10.1039/D5NR03553H
Porous organic cages for pollution removal and analysis
This review highlights the design and modification of porous organic cages to meet the requirements of pollution removal and analysis and their applications in the adsorption, separation and sensing of contaminants. Images reproduced with permission, full details in article.
Nanoscale, 2025,17, 24383-24403
https://doi.org/10.1039/D5NR03488D
Data driven approaches in nanophotonics: a review of AI-enabled metadevices
AI surrogates are displacing brute-force simulations in meta-optics; we review strategies from CNNs to LLMs that speed design, capture coupling, and yield fabrication-friendly, multifunctional devices.
Nanoscale, 2025,17, 23788-23803
https://doi.org/10.1039/D5NR02043C
Tailoring MXenes for energy storage: insights into element doping
Element doping can endow MXenes with enhanced electrochemical properties, catalytic performance, and structural characteristics. This review focuses on the doping mechanism, doping methods and applications of MXenes in the field of energy storage.
Nanoscale, 2025,17, 23804-23821
https://doi.org/10.1039/D5NR03386A
Recent advances in mass-sensing humidity sensors: mechanisms, materials, and applications
In this review, mass-sensing humidity sensors are comprehensively summarized from the aspects of humidity sensing mechanisms, humidity sensing materials, and emerging applications. Images reproduced with permission, see Figure 1 for details.
Nanoscale, 2025,17, 23763-23787
https://doi.org/10.1039/D5NR03048J
The curious case of anti-PEG antibodies
Humans are exposed to PEG and have ample opportunities to create anti-PEG antibodies.
Nanoscale, 2025,17, 22594-22605
https://doi.org/10.1039/D5NR02301G
Acid-stable oxygen-evolving catalysts: progress in non-precious material engineering and scalability barriers
This work breaks new ground by linking catalyst design with engineering needs for proton exchange membrane water electrolyzers, providing a roadmap for non-precious catalysts in acid conditions.
Nanoscale, 2025,17, 22566-22593
https://doi.org/10.1039/D5NR03118D
2D carbon-based dual pioneers: graphene oxide and graphdiyne guiding solar evaporation through three-dimensional mastery
Graphene oxide and graphdiyne enable solar evaporation through 3D mastery: broadband light harvesting, anisotropic heat confinement, and ion-selective water transport, reshaping optimization strategies for next-gen solar water-energy systems.
Nanoscale, 2025,17, 18981-18996
https://doi.org/10.1039/D5NR01104C
2D material-based infrared photodetectors: recent progress, challenges, and perspectives
2D materials-based infrared (IR) photodetectors are essential for a wide range of applications, including optical communication, night vision, and environmental monitoring; graphical images reproduced with permission; full details in paper.
Nanoscale, 2025,17, 17881-17918
https://doi.org/10.1039/D5NR01920F
Gallium-based nano-liquid metals enabled antimicrobial mechanisms and biomedical applications
This review summarizes the unique role of novel gallium-based nano-liquid metals in antibacterial applications, focusing on their distinctive activities and underlying antibacterial mechanisms. The graphical abstract was created in BioRender. R, z. (2025) https://BioRender.com/v96z429.
Nanoscale, 2025,17, 14441-14457
https://doi.org/10.1039/D5NR00406C
Inspiration of plant-related adhesion for plant wearable sensor interface design
This review presents a systematic framework outlining the construction strategies for adhesion layers in plant wearable devices, drawing inspiration from plant-based adhesion interfaces.
Nanoscale, 2025,17, 13057-13075
https://doi.org/10.1039/D5NR00359H
2D monolayer electrocatalysts for CO2 electroreduction
Through bridging the gap between 2D material and single-atom material, 2D monolayer materials exhibit great potential in CO2RR due to their unique structural/electronic properties, high atom utilization and low mass transfer resistance.
Nanoscale, 2025,17, 4212-4225
https://doi.org/10.1039/D4NR04109G
Recent advances in mRNA-based therapeutics for neurodegenerative diseases and brain tumors
mRNA-based therapeutics have entered the mainstream with seemingly limitless possibilities to treat neurodegenerative diseases and brain tumors.
Nanoscale, 2025,17, 3537-3548
https://doi.org/10.1039/D4NR04394D
Mechanical and electromechanical properties of 2D materials studied via in situ microscopy techniques
This review summarizes recent advancements in in situ microscopy techniques applied to the study of mechanical and electromechanical properties of 2D materials. The latest results, corresponding challenges and future opportunities are discussed.
Nanoscale, 2025,17, 1722-1763
https://doi.org/10.1039/D4NR03569K
From synthesis to chiroptical activities: advancements in circularly polarized luminescent inorganic quantum dots
Review of synthesis strategies for circularly polarized luminescence (CPL) inorganic quantum dots, influencing factors, theoretical insight into CPL mechanisms, and future applications/prospects. Images reproduced with permission, details in article.
Nanoscale, 2025,17, 158-186
https://doi.org/10.1039/D4NR03600J
Ultrasmall Glutathione-Protected Au/Cu and Their Alloy Nanoclusters with Specific ROS Generation
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR04022A
Non-invasive modulation of carrier injection efficiency via electronic phase separation at organic/inorganic interfaces
Magnetic-field-controlled phase separation in LPCMO dynamically shifts the interfacial barrier, offering a non-invasive route for amplifying carrier injection in hybrid organic/inorganic devices.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR04434K
Colloidally synthesized and bandgap-engineered luminescent titanium nitride quantum dots
We demonstrate the colloidal synthesis of luminescent titanium nitride (TiN) quantum dots with multicolor emission and tunable band gaps, providing safer alternatives to metal chalcogenides and halide perovskites for solar cells and LEDs.
Nanoscale, 2025,17, 25484-25489
https://doi.org/10.1039/D5NR03290C
Rapid and sustained growth of carbon nanotube forests through coupled support design and catalyst particle formation dynamics
This study breaks the long-standing trade-off between catalyst lifetime and carbon nanotube growth rate by combining support design with control over the catalyst formation process.
Nanoscale, 2025,17, 24999-25002
https://doi.org/10.1039/D5NR03783B
Oxygen vacancy-enriched SnO2/NiO n–p heterointerfaces for high-efficiency oxygen evolution reaction catalysis
Integrating electrospinning with post-calcination-mediated interfacial engineering has been developed to construct SnO2/NiO n–p junction hollow nanotube heterostructures, enabling efficient OER electrocatalysis in alkaline environments.
Nanoscale, 2025,17, 24990-24998
https://doi.org/10.1039/D5NR03372A
An evaluation of the size-dependent electrocatalytic activity of single IrO2 nanoparticles via nano-impact electrochemistry
This study employs nano-impact electrochemistry (NIE) to investigate the size-dependent electrocatalytic activity of single IrO2 nanoparticles, leveraging the technique's high mass transport and in situ analysis capabilities.
Nanoscale, 2025,17, 23930-23934
https://doi.org/10.1039/D5NR03219A
Structural distortions control scaling of exciton binding energies in two-dimensional Ag/Bi double perovskites
Structural distortions in Ag/Bi quasi-2D double perovskites are responsible for the unexpected trend in the exciton binding energies.
Nanoscale, 2025,17, 23924-23929
https://doi.org/10.1039/D5NR03010B
Atomic engineering of trace endogenous Fe within natural clays into a self-supported Fe1–P single-atom cocatalyst for photocatalytic hydrogen evolution
The trace endogenous Fe species within natural halloysite nanotubes have been engineered into a single-atom Fe1–P cocatalyst with high H2 evolution activity and stability in both dye-sensitized and semiconductor-based systems.
Nanoscale, 2025,17, 22795-22801
https://doi.org/10.1039/D5NR03464G
Designing a pseudocapacitive binary Zn/Mn perovskite fluoride anode with a conversion/alloying/insertion hybrid mechanism for advanced Na-ion capacitors and Na-based dual ion batteries
Designed a pseudocapacitive KZMF(3-1)@rGO anode material, explored its conversion/alloying/insertion hybrid mechanism by electrochemical analysis and ex situ characterization techniques, and constructed NICs and Na-DIBs devices.
Nanoscale, 2025,17, 21468-21474
https://doi.org/10.1039/D5NR03023D
Controllable syntheses of two structurally new {AsW9O33}-mediated silver alkynyl clusters
Two atomically-precise {AsW9O33}-mediated silver alkynyl clusters have been synthesized by adjusting mixed reaction solvents, showing efficient photothermal performance and catalytic activities towards the detoxification of 4-nitrophenol.
Nanoscale, 2025,17, 21475-21480
https://doi.org/10.1039/D5NR03313F
How octopod Mn–Fe oxide nanoparticle tracers minimize relaxation time and enhance MPI resolution
25 nm Octopod Mn–Fe oxide nanoparticles reduce crystal anisotropy, leading to faster relaxation times, a narrower MPI point spread function (PSF), and consequently improved spatial resolution.
Nanoscale, 2025,17, 21463-21467
https://doi.org/10.1039/D5NR02780B
Engineering gold nanosheets into bugle-like assemblies for plasmon-enhanced near-infrared oncology treatment
Low-symmetry, bugle-like gold nanocrystals fabricated by rolling Au nanosheets exhibit strong near-infrared absorption and outstanding photothermal therapeutic efficacy under 808 nm laser irradiation.
Nanoscale, 2025,17, 19117-19126
https://doi.org/10.1039/D5NR02366A
Unraveling a ligand-initiated oxidative etching pathway in gold nanoclusters
Thiol concentration governs the oxidative etching pathways of Au nanoclusters, switching between ligand-initiated and oxygen-initiated mechanisms, both leading to Au(I)-thiolate complexes via distinct intermediate steps.
Nanoscale, 2025,17, 19110-19116
https://doi.org/10.1039/D5NR02268A
Co-reduction coupling of bicarbonate and nitrate toward efficient urea synthesis
The spatial charge region is rationally designed by constructing a Mott–Schottky heterostructure in the Cu-WN catalyst, achieving accurate activation of NO3− and HCO3− to accelerate the targeted electrochemical C–N coupling reaction.
Nanoscale, 2025,17, 9086-9093
https://doi.org/10.1039/D4NR05196C
Lorentz force-assisted growth of romanesco-like Ni–Fe nano-cone arrays for enhanced oxygen evolution reaction at high current densities
A novel Lorentz-force-assisted electrodeposition method is introduced to fabricate Romanesco-like Ni–Fe nano-cone arrays with enhanced stability and efficient bubble release for the oxygen evolution reaction (OER) under high current densities.
Nanoscale, 2025,17, 8466-8475
https://doi.org/10.1039/D4NR05174B
Strong and reciprocal magneto-phonon effects in a 2D antiferromagnetic semiconductor FePSe3
Magnon–phonon coupling and spin-phonon interaction are interplays between phonons and magnetism, offering new approaches to manipulate phonons related to magnetism.
Nanoscale, 2025,17, 8476-8483
https://doi.org/10.1039/D4NR04743E
Novel iron–nickel bimetallic nanozyme with peroxidase-like activity for ultrasensitive uric acid detection and hyperuricaemia therapy evaluation
Illustration of novel iron-nickel bimetallic nanozyme with peroxidase-like activity for ultrasensitive uric acid detection and hyperuricaemia therapy evaluation.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR04096E
Helper Lipids Accelerate the Mass Transfer of Cationic Lipid Nanoparticles Resulting in an Efficient Gene Delivery
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03142G
Magnetocaloric effect observations near room temperature in few-layered chromium telluride (Cr2Te3)
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR04469C
Optical control of carrier-mediated ion transport by photoswitchable lipids
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR04234H
Stable 1T'' HfCl2 monolayer with strong excitonic effects and promising solar harvesting efficiency
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR04047G
Tuning the configuration of Ag–Cu aerogels for electrocatalytic applications
Ag–Cu metal aerogels exhibiting exceptional electrocatalytic properties were synthesized via micro-turbulence, promoting their distinctive 3D architecture formation through a nonclassical growth mechanism.
Nanoscale, 2025,17, 27289-27297
https://doi.org/10.1039/D5NR02475G
N-doped carbon nanofiber-supported amorphous Nb2O5 with synergistic Brønsted–Lewis sites for converting sorbitol to isosorbide
Nitrogen-doped carbon nanofiber-supported amorphous niobium oxide achieves 100% sorbitol dehydration conversion with an isosorbide yield of 84%.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03255E
Controlled colloidal synthesis of anisotropic mixed-metal chalcohalides: insights into morphology and phase evolution
A facile dual injection synthesis protocol enabling precise phase control in the production of mixed metal chalcohalide anisotropic crystals. Sequential transformation of seeds drives formation of the quaternary chalcohalide.
Nanoscale, 2025,17, 27225-27232
https://doi.org/10.1039/D5NR03842A
Joule-heating synthesis of Pd/C catalysts with excellent electrocatalytic performance
A facile solid-phase synthesis strategy that couples ball milling with rapid Joule-heating to fabricate Pd/C catalysts for high-performance electrocatalysis.
Nanoscale, 2025,17, 27281-27288
https://doi.org/10.1039/D5NR03851K
Regulating the crystallization behavior of quasi-2D Dion–Jacobson tin perovskites with a non-linear organic spacer
The strong interaction between non-linear MDAN2+ and perovskite octahedra induced rapid nucleation and slow growth of tin halide perovskites, promoting the formation of high-quality tin perovskite films and enhancing device performance and stability.
Nanoscale, 2025,17, 27242-27249
https://doi.org/10.1039/D5NR03937A
Modulation of specific interactions within a viral fusion protein predicted from machine learning blocks membrane fusion
A machine learning model is developed to rapidly identify a critical residue at the fusion loop, when mutated, the fusion protein completely abrogates membrane fusion.
Nanoscale, 2025,17, 27250-27258
https://doi.org/10.1039/D5NR03235K
Synergistic Zn2+ desolvation and diffusion acceleration for high-performance aqueous zinc batteries at low temperature
VO-PBA facilitates Zn2+ diffusion both at the electrolyte–cathode interface and within the cathode bulk, significantly improving low-temperature performance.
Nanoscale, 2025,17, 27259-27268
https://doi.org/10.1039/D5NR03836G
Carbon dots derived from ginger for inhibiting inflammatory osteolysis
A new kind of carbon dots are synthesized from ginger, with excellent biocompatibility, potent reactive oxygen species scavenging ability, and significant anti-inflammatory effects, which can be used for treating inflammatory osteolytic diseases.
Nanoscale, 2025,17, 27269-27280
https://doi.org/10.1039/D5NR03158C
Computational roadmap of stable Mo–S nanoclusters: atomic structures and magic compositions
Computational screening reveals 22 novel stable Mo–S nanoclusters and identifies the planar Mo10S20 ring as a stable building block for extended nanostructures like nanotubes and thin films.
Nanoscale, 2025,17, 27233-27241
https://doi.org/10.1039/D5NR02304A
Broad-range flow velocimetry enabled by pulse-width-dependent luminescence of core–multishell upconversion nanoprobes
Lanthanide-doped upconversion nanoparticles (UCNPs) have garnered extensive attention in fundamental research and cutting-edge applications due to their unique optical properties.
Nanoscale, 2026, Advance Article
https://doi.org/10.1039/D5NR03368C
Role of Weak and Transient Interactions in Polymer-Free Electrospinning of β-Cyclodextrin Derivatives
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03980K
Sc(OTf)3-Induced, Selective Removal of Alkynyl Ligands from Heteroleptic Au13 and Au38 Nanoclusters
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03977K
Tetramethylolphosphonium chloride-inspired gold nanoclusters endow a heavy metal ion sensor array by pH-regulated surface ligand-metal chelation
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR04413H
Tailored charge storage mechanism of a nickel metavanadate/polyaniline composite for high-performance hybrid supercapacitors
Hybrid materials that integrate battery-type and supercapacitive properties hold significant promise for next-generation energy storage systems.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03584H
About this collection
This ongoing web collection features all the articles published in Nanoscale in 2025 that have been highlighted as HOT by our reviewers. Congratulations to all the authors whose articles are featured!