Paper
Development of PROTACs for targeted degradation of oncogenic TRK fusions
JWJ-01-378 recruits cereblon (CRBN) to induce potent and selective degradation of oncogenic TRK fusions, leading to a collapse in signaling and loss of cancer cell viability. Graphic was created using https://biorender.com.
Paper
Comparative analysis of alkyne- and desthiobiotinylated photoaffinity probes for chemotranscriptomic profiling
The suitability of desthiobiotin and alkyne modified Ribocil photoaffinity probes for chemotranscriptomic profiling were compared. Desthiobiotin appears to unselectively interact with RNA, rendering it unfavorable for transcriptome-wide studies.
Paper
Integration of palladium-catalyzed C–N coupling into self-encoded libraries for accelerated hit discovery
We expanded the self-encoded library (SEL) platform via C–N cross-couplings, testing 170+ building blocks and generating a 25.725-member library. We established automated MS/MS decoding and demonstrated robust hit enrichment in screens against CAIX.
Paper
An AKR1C3-activated kinase inhibitor prodrug
Enzymatically activated prodrugs can enable context-specific kinase inhibition.
About this collection
RSC Chemical Biology is proud to present this collection of invited contributions from early career researchers who are making significant contributions to the field of chemical biology. Congratulations to all of the featured researchers!