This review highlights recent advancements in the development of pyrrolo[2,3-d]pyrimidine derivatives as antimicrobial agents, covering synthetic methodologies, structural diversification, bioactivity evaluation, limitations, and emerging strategies.
A new synthetic route towards 6-azaindoles (pyrrolo[2,3-c]pyridines) and pyrrolo[2,3-d]pyridazines starting from 4-aroyl pyrroles is described.
The antioxidant activity of five derivatives of 3-hydroxy-3-pyrroline-2-one was effectively assessed after synthesis.
A two-pot process is developed to access pyrrolo[2,3-d]pyridazin-7-one's and pyrrolo[2,3-d]pyrizidines through the pyrrole-2,3-dione as an intermediate compound.
A series of eighteen pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidine derivatives were designed and synthesized as novel tacrine-like AChE inhibitors.