This review summarizes recent advances (last 5 years) in C–H halogenation via directing groups like amides, carboxylic acids, 8-aminoquinoline, N-oxides, and heterocycles, emphasizing regioselective aryl halide synthesis in modern organic chemistry.
Metal/photocatalyst-free light-driven benzylic C–H halogenation via an EDA complex offering mild conditions, broad functional group tolerance, and late-stage functionalization of complex molecules.
The site-selective C–H bond fluorination of substituted aromatics at the electronically and geometrically disfavored meta-position is of great interest and importance in medical chemistry and organic chemistry, yet has remained unexplored to date.
A decoupled HAT and radical capture strategy using formal copper(III) complexes enables selective C–H 18F-fluorination. The distinct selectivity arises from asynchronicity PCET, contrasting the conventional C–H activation selectivity based on BDFE.
We describe our efforts to develop a decatungstate (DT)-catalyzed C–H 18F- and 19F-fluorination reaction, and the discovery and exploitation of electrostatic effects in DT catalysis for the synthesis of radiotracers for PET imaging.