An engineered imine reductase (IRED) was developed specifically for 2-tetralone substrate, and utilized in the total synthesis of rotigotine.
Molecular crystal structure prediction has matured to the point where it can routinely facilitate the discovery and design of new organic materials.
Parkinson's disease (PD) remains one of the most formidable challenges in central nervous system (CNS) drug delivery due to the restrictive blood–brain barrier (BBB) and limited efficacy of current dopaminergic therapies. Created in BioRender. Fahmy, S. (2025) https://BioRender.com/vsusgrv.
Brain disorders affect over one billion people globally, presenting significant challenges for effective treatment due to the limited drug bioavailability in the brain. The graphical abstract was created with BioRender.
The solid form of an API depends on its thermodynamic stability and kinetic persistence. It is therefore important to understand its phase behaviour symbolised by the ternary phase diagram, but also the kinetics of possible phase transformations.