Experimental and theoretical ROA studies of deuterated glucose derivatives in the C–D stretching region demonstrated the usefulness of ROA signals in this region for stereochemical and conformational analysis.
A readily accessible and eco-friendly sodium salt of β-C-glucosyl barbiturate has been discovered to be a powerful low molecular-weight oleogelator of a wide range of fatty phases.
Schematic model of the mechanism of Y473 phosphorylated UGDH relieving the inhibition of UDP-Glc on HuR.
A set of proline-diacylhydrazine hybrid molecules were designed and synthesized. Their conformational analyses showed a synergistic relationship between n → π* and nN → π*Ar interactions, which played a key role in Xaa–Pro trans amide bond stabilization.
The hydrogen bond enhanced halogen bond can be modulated by changing substituents on the HB or XB donor ring. Thus, distant substituents can impact nearby noncovalent interactions and this can be used as a viable approach for molecular design.