A visible-light-mediated selective difluoroalkylation of α-trifluoromethyl alkenes with difluoroalkylating reagents was developed. This protocol allowed the formation of gem-difluoroalkene difluoroacetates and trifluoromethylated difluoroacetamides.
A direct synthetic approach to α,α-difluoro-β-amino amides via the zinc-promoted Reformatsky reaction of aldimines using bromodifluoroacetamides and the selective reduction of their amino amides to 2,2-difluoropropane-1,3-diamines.
The present review focuses on recent progress (2021–2025) in EDA-enabled photocyclization for constructing various heterocyclic and carbocyclic skeletons.
We herein describe a photo-induced EDA-enabled multicomponent reaction of alkenes, heterocycles and Br–Rf, offering a mild alternative to traditional post modification of nitrogen heterocycles.
A metal-free visible-light-promoted reaction of N-phenylacrylamide with bromodifluoroacetamide via electron-donor–acceptor complexes was carried out and demonstrated a broad substrate scope and good functional group tolerance.