Kinetic resolution of spirocyclic 2-arylpiperidines was achieved with sparteine as a chiral ligand.
A chemodivergent organolithium-mediated protocol to promote anionic Fries rearrangement (AoF) or kinetic resolution (KR) processes starting from O-aryl carbamates of 2-substituted piperidines is reported.
An external-oxidant-free method for synthesizing β-sulfonylated piperidines is established via a visible-light-driven three-component reaction. The reaction proceeds smoothly at room temperature, delivering products with good substrate generality.
A transition metal-free strategy for the α,β-C(sp3)–H dehydrogenative diazotization of piperidines has been developed. This method proceeds at room temperature under air, eliminating stoichiometric external oxidants and harsh conditions.
Herein we have developed a convenient method for the tunable synthesis of α,β-multifunctionalized azaheterocycles via the oxoammonium salt promoted cascade reaction of saturated cyclic amines with different nucleophiles.