This article summarizes recent efforts in developing enantioselective palladium- and nickel-catalyzed ring-opening/coupling reactions of cyclobutanones with a tethered aryl halide.
γ-Lactam is obtained from cyclobutanones using oxime reagents in the presence of a catalytic amount of Brønsted acid under mild conditions via transoximation and the Beckmann rearrangement mechanism.
This review aims to collect advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years, and it is organized into thirteen sections depending on the different types of transformations involved.
A visible-light one-pot strategy synthesizes pyridinyl-cyclobutanones via sequential [2 + 2] photocycloaddition and photo-Nef of nitroalkenes and 2-vinylpyridines, achieving high yields without isolating intermediates.
The contrasting effects of cobalt and rhodium on the reaction mechanisms and chemoselectivity of the cyclizations of dienyl aldehydes were investigated.