Cong Fu, Mingjin Xu, Qicai Ma, Wenjing Wang, Shanyue Li, Qingjie Zhao and Wei Zhou
Org. Chem. Front., 2025,12, 2299-2304
Abstract
A versatile synthesis of triazole-fused piperazin-2-one and [1,4]diazepin-4-one scaffolds via a cascade azide–alkyne cycloaddition/oxetane ring opening reaction is reported.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta and Hideaki Fujii
RSC Med. Chem., 2024,15, 4001-4010
Abstract
The incorporation of saturated nitrogen-containing heterocycle 1,2,5-oxadiazinane into small molecules represents a compelling avenue in drug discovery due to its unexplored behavior within biological systems and incomplete protocols for synthesis.
Yanlong Kang, Yan Li and Zhiqiang Zhang
New J. Chem., 2025,49, 15623-15630
From themed collection:
New Journal of Chemistry HOT Articles
Abstract
Reaction mechanisms and origins of regio- and stereoselectivities of NHC-catalyzed [12+2] annulation of 5H-benzo[a]-pyrrolizine-3-carbaldehydes and cyclic sulfonic imines.
Yiting Pu, Tong Shao, Shaohua Yang, Haneol Cho, Chansoo Kim, Uk Sim, Shuihua Wang and Heechae Choi
Org. Biomol. Chem., 2026, Advance Article
Abstract
This review summarizes asymmetric hydrogenation strategies for N-heterocycles, integrating DFT-derived mechanistic insights to rationalize stereoselectivity and access key chiral scaffolds found in modern drugs.
François Richard, Paul Clark, Al Hannam, Thomas Keenan, Alexandre Jean and Stellios Arseniyadis
Chem. Soc. Rev., 2024,53, 1936-1983
From themed collection:
Celebrating the scientific accomplishments of RSC Fellows
Abstract
This review analyses recent advances and strategies employed in the Pd-AAA of nucleophilic prochiral heterocycles. Each section is focused on a specific heterocycle, where optimisation data and reaction scope have been carefully analysed.