Peroxide-cleavable arylboronates are stable linkers for the generation of efficacious antibody–drug conjugates.
A glucocorticoid receptor modulator (GRM) was conjugated to a mouse anti-TNF antibody using various dipeptide linkers. Impact of dipeptide linkers on ADC physical properties, including solubility, hydrophobicity, and aggregation were evaluated.
Maleimide is used in antibody–drug conjugate (ADC) generation to attach the drug-linker to the antibody. Maleimide linkers with hydrolysis-enabled maleimides were designed. Corresponding ADCs were made and subjected to thermal stress, and succinimide ring hydrolysis and drug release were measured.
For an optimal ADC the symbiotic relationship of the three structurally disparate components requires they all function in unison and medicinal chemistry has a huge role to enable this.
This review focuses on the sustainable synthesis of hydrogen peroxide (H2O2) via 2e− ORR. It emphasizes ADC design strategies. It bridges fundamental research and industrial practices to drive the advancement of green chemical synthesis.