This review explores various catalytic strategies for achieving diverse diastereomeric outcomes in asymmetric conjugate additions creating carbon–carbon bonds.
This review presents an overview of recent developments and trends in chiral Brønsted acid mediated rearrangement reactions. Different mechanisms and activation modes are summarized to illustrate the regio- and stereo-selectivity in the reactions.
The asymmetric catalytic synthesis of 1,2-diamines has received considerable interest, due to their presence in biologically active compounds and their applications for the development of synthetic building blocks, chiral ligands and organocatalysts.
An enantio- and diastereoselective allylboration of sterically hindered aldehydes utilizing multiple hydrogen bonding interactions between chiral phosphoramide catalyst has been established.
An in-depth analysis including NMR-spectroscopy at 180 K and computer simulations suggests an OHN hydrogen bond between the phosphoramide oxygen and the imine instead of the mostly proposed NHN H-bond in binary NTPA/imine complexes.