Suvankar Banerjee, Nilanjan Adhikari and Balaram Ghosh
RSC Med. Chem., 2026,17, 208-224
Abstract
Discovery timeline of HDAC8-degrading PROTACs.
Priyanka Ray, Abbas Sedigh, Matthew Confeld, Lina Alhalhooly, Kweeni Iduoku, Gerardo M. Casanola-Martin, Hai Pham-The, Bakhtiyor Rasulev, Yongki Choi, Zhongyu Yang, Sanku Mallik and Mohiuddin Quadir
J. Mater. Chem. B, 2024,12, 9905-9920
Abstract
This study presents the synthesis of enzyme-responsive nanoparticles targeting HDAC8, an epigenetic enzyme, through a deacetylation reaction. This first-time report highlights the potential for these particles to mimic synthetic histones.
Samima Khatun, Venkatesh Muthukumar, Ambati Himaja, Indrasis Dasgupta, Kalpataru Das, Balaram Ghosh and Shovanlal Gayen
RSC Med. Chem., 2026, Advance Article
Abstract
A novel series of indole-based hydroxamic acids was designed, synthesized, and evaluated as promising HDAC8 inhibitors for lung cancer therapy.
Urvashi Patel, Joshua P. Smalley and James T. Hodgkinson
RSC Chem. Biol., 2023,4, 623-634
From themed collection:
Medicinal Chemistry Small Molecule Probes
Abstract
A review on current proteolysis targeting chimeras (PROTACs) as chemical probes for histone deacetylase (HDAC) enzymes.
Seungyong You, Sakurako Tani, Sanku Mallik, Zhongyu Yang, Mohiuddin Quadir and Yongki Choi
Catal. Sci. Technol., 2025,15, 7324-7328
From themed collection:
Catalysis Science & Technology Open Access Spotlight 2025
Abstract
Single-molecule analysis reveals how ligand modifications synergistically control HDAC8 catalysis by stabilizing active conformations, providing mechanistic insights into ligand-regulated enzymatic catalysis.