Suvankar Banerjee, Nilanjan Adhikari and Balaram Ghosh
RSC Med. Chem., 2026,17, 208-224
Abstract
Discovery timeline of HDAC8-degrading PROTACs.
Priyanka Ray, Abbas Sedigh, Matthew Confeld, Lina Alhalhooly, Kweeni Iduoku, Gerardo M. Casanola-Martin, Hai Pham-The, Bakhtiyor Rasulev, Yongki Choi, Zhongyu Yang, Sanku Mallik and Mohiuddin Quadir
J. Mater. Chem. B, 2024,12, 9905-9920
Abstract
This study presents the synthesis of enzyme-responsive nanoparticles targeting HDAC8, an epigenetic enzyme, through a deacetylation reaction. This first-time report highlights the potential for these particles to mimic synthetic histones.
Urvashi Patel, Joshua P. Smalley and James T. Hodgkinson
RSC Chem. Biol., 2023,4, 623-634
From themed collection:
Medicinal Chemistry Small Molecule Probes
Abstract
A review on current proteolysis targeting chimeras (PROTACs) as chemical probes for histone deacetylase (HDAC) enzymes.
Rui Lai and Hui Li
Phys. Chem. Chem. Phys., 2025,27, 7120-7138
Abstract
A three-step catalytic mechanism is obtained from MP2/MM geometry optimization for HDAC8. Comparison of different QM/MM methods highlights the importance of using accurate QM methods in the study of enzyme catalysis.
Yi-Chuang Xu, Hua Zheng, Xiao-Ying Tan, Christer Hogstrand, Tao Zhao, Xiao-Lei Wei and Zhi Luo
Environ. Sci.: Nano, 2024,11, 4240-4254
From themed collection:
HOT articles from Environmental Science: Nano
Abstract
Understanding the toxicity and hazard risk of various metal sources is very important and can provide new insights for their risk evaluation in the environment.