Highly efficient asymmetric hydrogenation of dibenzo-fused azepines derivatives with chiral cationic Ru diamine catalysts has been developed, giving diverse chiral seven-membered N-heterocycles with excellent results (up to 99% yield and 99% ee).
Polycyclic benzo-δ-phosphonolactams were synthesized from readily available ethyl arylmethylphosphonochloridates and dibenzo[b,f][1,4]oxazepines via one-pot [4+2] annulation.
We have successfully developed a silver-free Rh(III)-catalyzed redox-neutral regioselective [3+2]-spiroannulation of dibenz(ox)azepines and ynones to access dibenz(ox)azepines containing α-aroyl spiro-indenamines.
An efficient visible-light-induced Staudinger [2 + 2] annulation reaction under catalyst-free conditions has been established, and tetracyclic dibenzo[b,f][1,4]oxazepine/thiazepine-fused β-lactams were synthesized with a broad substrate scope and high efficiency (37 examples, up to >99% yield).
A metal-free visible light-induced cross-dehydrogenative coupling of aldimines with nucleophiles in a one-pot fashion is first reported, which features high efficiency,the absence of external oxidants, and mild and redox-neutral reaction conditions.