The novel pH-responsive property of the N-sulfonyl amidine (SAi) structure was applied in the design of conformation–transition polypeptides as a “smart” drug-delivery system to achieve site-specific tumor penetration and drug release.
Self-assembled structures from mono-functionalized, di-functionalized and multi-functionalized POSS cages with various polymeric attachments, including PS, PMMA, phenolic, PVPh, and polypeptides.
This review systematically describes the preparation of poly(amino acids) and peptides, and their use in drug loading for various diseases, offering insights for research and clinical applications of degradable biomedical polymers.
This review discusses the structural features of polycations, which make them thermoresponsive, showing either LCST or UCST behavior. The role of hydrophobic counter ions is of particular interest.
This review comprehensively summarized the design strategies of peptide-based stimuli-responsive drug delivery systems, along with an analysis of their advantages and limitations.