A Lewis and Brønsted acid-mediated annulation reaction of o-alkynylbenzaldehydes with nitriles has been developed for the construction of amide-substituted benzo[a]fluorene derivatives.
An [IPrAu(I)]+-enabled facile construction of 1-peroxidized 1H-isochromenes from 2-alkynyl-1-carbonylbenzenes and TBHP via tandem cyclization/nucleophilic addition was successfully achieved.
A method for the chemodivergent assembly of a diverse range of cyclohepta[b]indolines which relies on PtI4-catalyzed oxidative and hydrogenative dearomative [3 + 2] cycloaddition of 1H-indole N-tethered o-alkynylbenzaldehydes is described.
A one-pot two-step cyclocarboamination of o-alkynylbenzaldehydes with tertiary alkyl primary amines was realized to afford a range of 3-aminoindenes and cis-1-amino-2-arylindanes with excellent chemo- and diastereo-selectivity.
This study uses density functional theory (DFT) to examine the gold(I)-catalyzed cascade cyclization of 1,4-dienyl-tethered 2-alkynylbenzaldehydes.