Bao-Gui Cai, Li-Hua Zhang, Yang Xie, Qiong Zhang and Jun Xuan
Org. Chem. Front., 2026, Advance Article
From themed collection:
2026 Organic Chemistry Frontiers HOT Articles
Abstract
A catalyst-free, visible-light-induced annulation of 2H-azirines and hydrazonyl chlorides via EDA activation affords 1,3,5-triazines or imidazoles. The 2H-azirine substitution pattern controls reactivity, giving a practical route to N-heterocycles.
Alvi Muhammad Rouf and Jun Zhu
Phys. Chem. Chem. Phys., 2023,25, 12602-12606
Abstract
An unconventional route is proposed to achieve persistent 1H-azirine (usually unreachable at ambient conditions), from its more stable isomer 2H-azirine.
Mi-Na Zhao, Zi-Mo Yang and Lian-Qing Li
Chem. Commun., 2024,60, 1904-1907
Abstract
The Fe(II)-catalyzed cyclization of 2H-azirines and N,N-dimethylformamide as an amine source has been developed for the synthesis of 1-methyl-4,5-diaryl-1H-imidazoles.
Subrata Biswas, Arnab Roy, Surajit Duari, Srabani Maity, Asma M. Elsharif and Srijit Biswas
Org. Biomol. Chem., 2024,22, 4697-4703
Abstract
A TfOH-catalysed ring opening of 2H-azirines by 2-mercaptopyridines and thiazole-2-thiols is reported to access imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazoles in one pot.
Wen Cheng, Mengfan Li, Hao Tang, Yuxi Wang, Qiurou Yu, Xiaoli Bao, Yunhui Zhao and Weiyin Yi
Org. Biomol. Chem., 2026,24, 2046-2060
Abstract
Two copper-controlled reactions of 2H-azirines with TosMICs have been developed that provide two efficient and modular approaches to diverse substituted pyrimidines with non-electron-withdrawing substituents at position 4 or 6.
![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
N bond cleavage