Michael S. Lichstrahl, Lukas Kahlert, Rongfeng Li, Trevor A. Zandi, Jerry Yang and Craig. A. Townsend
Chem. Sci., 2023,14, 3923-3931
From themed collection:
#MyFirstChemSci 2023
Abstract
A small library of stereochemically-defined α,β-diamino acids has been prepared to generate non-native monobactams through fermentation, highlighting the potential of this platform for directed biosynthesis.
Mark S. Butler and Robert J. Capon
Nat. Prod. Rep., 2026,43, 813-896
Abstract
This review captures the legacy of natural products in shaping modern infection control and highlights their potential for delivering the next generation of life-saving antibiotics.
Phanankosi Moyo, Ikhane O. Albert, Neo Hlungwani, Thulani Sibanda, Perfoy Lumu, Ndivhuwo Kevin Khorommbi, Gurleen Kaur, Karina Calvopina Tapia, George Siegwart, Nana Kwaku Buabeng, Cynthia A. Danquah, Lyndy J. McGaw, Sekelwa Cosa, Christopher J. Schofield and Vinesh J. Maharaj
Nat. Prod. Rep., 2026, Advance Article
Abstract
From the discovery of natural β-lactam antibiotics to the rise of serine and metallo-β-lactamases, this review traces their co-evolution and highlights microbial and plant-derived natural products as promising sources of new β-lactamase inhibitors.
Miyanou Rosales-Hurtado, Fanny Faure, Filomena Sannio, Federica Verdirosa, Georges Feller, Elodie Carretero, Yen Vo-Hoang, Patricia Licznar-Fajardo, Suzanne Peyrottes, Jean-Denis Docquier and Laurent Gavara
Org. Biomol. Chem., 2025,23, 389-399
Abstract
Based on the Buchwald–Hartwig amination reaction, an original β-lactam pronucleosides series was synthesized and microbiologically evaluated.
Tahlia Hatzisarantinos, Elissar Mansour, Jonathan J. Du, Mohamed Fares, David E. Hibbs and Paul W. Groundwater
RSC Med. Chem., 2025,16, 5770-5786
From themed collection:
Antimicrobial Resistance
Abstract
Active sites of the a serine- (OXA-23 [PDB 4JF6]) and b metallo- (NDM-1 [PDB 5YPL]) β-lactamases.