Michael S. Lichstrahl, Lukas Kahlert, Rongfeng Li, Trevor A. Zandi, Jerry Yang and Craig. A. Townsend
Chem. Sci., 2023,14, 3923-3931
From themed collection:
#MyFirstChemSci 2023
Abstract
A small library of stereochemically-defined α,β-diamino acids has been prepared to generate non-native monobactams through fermentation, highlighting the potential of this platform for directed biosynthesis.
Mark S. Butler and Robert J. Capon
Nat. Prod. Rep., 2026, Advance Article
Abstract
This review captures the legacy of natural products in shaping modern infection control and highlights their potential for delivering the next generation of life-saving antibiotics.
Miyanou Rosales-Hurtado, Fanny Faure, Filomena Sannio, Federica Verdirosa, Georges Feller, Elodie Carretero, Yen Vo-Hoang, Patricia Licznar-Fajardo, Suzanne Peyrottes, Jean-Denis Docquier and Laurent Gavara
Org. Biomol. Chem., 2025,23, 389-399
Abstract
Based on the Buchwald–Hartwig amination reaction, an original β-lactam pronucleosides series was synthesized and microbiologically evaluated.
Tahlia Hatzisarantinos, Elissar Mansour, Jonathan J. Du, Mohamed Fares, David E. Hibbs and Paul W. Groundwater
RSC Med. Chem., 2025,16, 5770-5786
From themed collection:
Antimicrobial Resistance
Abstract
Active sites of the a serine- (OXA-23 [PDB 4JF6]) and b metallo- (NDM-1 [PDB 5YPL]) β-lactamases.
Mbongeni Shungube, Nakita Reddy, Terisha Ghazi, Kimberleigh B. Govender, Ravesh Singh, Afsana Kajee, Anil Chuturgoon, Hendrik G. Kruger, Per I. Arvidsson, Dileep Tiwari, Thavendran Govender and Tricia Naicker
RSC Adv., 2025,15, 23427-23440
Abstract
Eight new MBL inhibitors, designed using a 1,4,7-triazacyclononane (NO3PY) chelator linked to a β-lactam, restored the efficacy of meropenem, reducing its minimum inhibitory concentration against MBL-expressing pathogens.