A new chiral ferrocene-tethered ruthenium diamine catalyst has been developed for the asymmetric transfer hydrogenation of different types of ketones.
The chirality introduced at the C1 position of 1-substituted-1,2,3,4-tetrahydroisoquinolines, obtained by four methods of enantioselective reduction of 1-substituted-3,4-dihydroisoquinolines, are vital for various biological activities.
The first example of manganese-catalyzed asymmetric transfer hydrogenation of N-heteroaromatics in water with good yields and ee up to 99%.
This review aims to provide a thorough overview of recent advancements in the synthesis of chiral vicinal amino alcohols, with a particular focus on strategic developments over the past two decades.
We herein report a rhodium-catalyzed asymmetric transfer hydrogenation (ATH) of α-chloro β-ketophosphonates via dynamic kinetic resolution (DKR) with up to 99% ee and >99 : 1 dr under mild conditions.