In this review, we explore the applications of Asymmetric Hydrogenation (AH) and Asymmetric Transfer Hydrogenation (ATH) in the total synthesis of natural flavonoids and their analogues, highlighting the limitations and opportunities in the field.
An iridium complex with a cinchona alkaloid derived NNP ligand efficiently catalyzed asymmetric transfer hydrogenation of aromatic ketones using i-PrOH as the hydrogen source.
Six novel Noyori–Ikariya complexes, containing a heterocyclic group at the sulfonyl position, were used as catalysts for the ATH of ketones. Alcohols were formed in high conversion and ee, including ortho-substituted derivatives.
A new chiral ferrocene-tethered ruthenium diamine catalyst has been developed for the asymmetric transfer hydrogenation of different types of ketones.
para- or meta-Bpin-containing acetophenone derivatives were reduced by asymmetric transfer hydrogenation (ATH), using Noyori–Ikariya catalysts, with formic acid/triethylamine, to alcohols in high enantiomeric excess.