Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery

Wenna Shi, Hui Xue, Tianwei Du, Jun-Li Liu, Victor Ling, Yuzhuo Wang, Zhenwei Ma and Zu-hua Gao

Biomater. Sci., 2024, 12, 5620
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Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair

Shunli Wu, Hao Zhang, Sicheng Wang, Jinru Sun, Yan Hu, Han Liu, Jinlong Liu, Xiao Chen, Fengjin Zhou, Long Bai, Xiuhui Wang and Jiacan Su

Mater. Horiz., 2023, 10, 3507
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Annulus Fibrosus Repair via Interpenetration of a Non‐Woven Scaffold Supports Tissue Integration and Prevents Re‐Herniation

Esteban D. Ongini, Mohammed Abdullah, Julie B. Engiles, Brianna S. Orozco, Andrea Moehl, Ana Peredo, Sonal Mahindroo, Rachel Hilliard, Thomas P. Schaer, Robert L. Mauck, Harvey E. Smith, Mazda Farshad, Jess G. Snedeker and Sarah E. Gullbrand

JOR Spine, 2025, 8
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Advanced hydrogel therapeutics for intervertebral disc degeneration: Engineering structural–functional properties in natural and synthetic biomaterials

Tao Chen, Dading Lu, Siqiao Wang, Huiyi Yang, Wenyong Fan, Zhihui Xiao, Zhaojie Wang, Pooyan Makvandi, Rongrong Zhu and Liming Cheng

Bioengineering & Transla Med, 2025, 10
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Bioinspired Printable Tough Adhesives with In Situ Benignly Triggered Mechanical Enhancements

Zhenwei Ma, Ran Huo, Alexander Nottegar, Christopher Chung‐Tze‐Cheong, Qiman Gao, Xiaoyi Lan, Zu‐hua Gao and Jianyu Li

Adv Funct Materials, 2024, 34
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Multifunctional naturally derived bioadhesives: From strategic molecular design toward advanced biomedical applications

Mahshid Kharaziha, Thomas Scheibel and Sahar Salehi

Progress in Polymer Science, 2024, 150, 101792
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A Nucleobase‐Driven Self‐Gelled Hyaluronic Acid‐Based Injectable Adhesive Hydrogel Enhances Intervertebral Disc Repair

Rong Yang, Biao Wang, Xiaoping Zhang, Yage Sun, Yiming Zhang, Ziyang Xu, Qiang Yang and Wenguang Liu

Adv Funct Materials, 2024, 34
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NanoCRISPR-assisted biomimetic tissue-equivalent patch regenerates the intervertebral disc by inhibiting endothelial-to-mesenchymal transition

Yong Huang, Hao Li, Lin Qi, Zhe Wang, Zheng Liu, Ruibang Wu, Qian Chen, Ce Zhu, Dan Sun, Limin Liu, Li Zhang and Ganjun Feng

Biomaterials, 2025, 322, 123404
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Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models

Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu and Justin J. Cooper‐White

Cell Proliferation, 2025, 58
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Combined nucleus pulposus and annulus fibrosus bioactive scaffolds enhance intervertebral disc defect regeneration

Zhenhua Li, Yanju Jia, Tongxing Zhang, Lilong Du, Wen Li, Jianhua Li, Kaihui Zhang, Yiming Jia, Meifeng Zhu and Baoshan Xu

Chemical Engineering Journal, 2024, 487, 150548
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Composite Hydrogel Sealants for Annulus Fibrosus Repair

Xuan Li, Ran Huo, Li Li, Hosni Cherif, Xiaoyi Lan, Michael H. Weber, Lisbet Haglund and Jianyu Li

ACS Biomater. Sci. Eng., 2024, 10, 5094
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Application of adhesives in the treatment of cartilage repair

Haoyang Feng, Kai Ang, Pengfei Guan, Junji Li, Huan Meng, Jian Yang, Lei Fan and Yongjian Sun

Interdisciplinary Medicine, 2024, 2
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Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

Xuan Li, Yin Liu, Shiyu Liu, Nicole Y. K. Li‐Jessen, Lisbet Haglund, Baolin Huang and Jianyu Li

Advanced Therapeutics, 2024, 7
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Mechanically active polymeric adhesives (MAPAs) for tissue regeneration

Ziming Zhao, Ran Yang, Binggang Chen, Chao Wang, Shujun Zhang, Changhong Linghu, Ping Wang, Shifang Luan, Huajian Gao and K. Jimmy Hsia

Progress in Materials Science, 2026, 159, 101658
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Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases

Qizhu Chen, Zitian Zheng, Mian Lin, Zhengyu Guo, Hongjie Huang, Qingyun Xue, Shengdan Jiang, Jianquan Wang and Aimin Wu

Small Science, 2024, 4
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Biocompatible Glues: Recent Progress and Emerging Frontiers in Surgical Adhesion

Marine Boursier, Yves Bayon, Claire Negrell, Julien Pinaud and Sylvain Caillol

Polymers, 2025, 17, 1749
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Polyphenol-modified biomimetic bioadhesives for the therapy of annulus fibrosus defect and nucleus pulposus degeneration after discectomy

Yan Ju, Shiyuan Ma, Meimei Fu, Min Wu, Yue Li, Yue Wang, Meihan Tao, Zhihui Lu and Jinshan Guo

Acta Biomaterialia, 2024, 189, 116
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Recent Advances in Multifunctional Naturally Derived Bioadhesives for Tissue Engineering and Wound Management

Aliakbar Jafari, Ahmed Al‐Ostaz and Sasan Nouranian

Polymers for Advanced Techs, 2024, 35
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Chitin nanocrystal-reinforced chitin/collagen composite hydrogels for annulus fibrosus repair after discectomy

Mingzhi Liu, Zhiyong Cui, Derong Xu, Chenguang Liu and Chuanli Zhou

Materials Today Bio, 2025, 31, 101537
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A coupled viscoelastic-damage model for rate-dependent noncovalent hydrogel adhesion under lap shear: Theory and experiments

Daochen Yin, Jiabao Bai, Zihang Shen, Yijie Cai, Siqi Yan, Zheyu Dong, Shaoxing Qu and Zheng Jia

Journal of the Mechanics and Physics of Solids, 2026, 211, 106562
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Decoding intervertebral disc degeneration pathomechanics: from mechanisms to therapeutic horizons

HanLin Qiao, TongLei Chen, Jing Yu, Chen Li, Chang Gao, YanJun Yang, YiCai Zhang, HuiLin Yang, ZhanJun Yan and ChangDong Lin

Journal of Advanced Research, 2026
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Thermo/Pressure-Sensitive Self-Fixation Surgical Meshes: The Role of Adhesive Hydrogels in Interface Attachment

Sonia Lanzalaco, Xavier Sánchez, Carlos Alemán, Christine Weis, Kamelia A. Traeger, Pau Turon and Elaine Armelin

ACS Appl. Polym. Mater., 2023, 5, 9898
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Progress of smart material in the repair of intervertebral disc degeneration

Yisi Liu, Jie Hu, Hao Jiang, Hui He, Liwei Yao, Qianglong Chen, Lijie Wang, Ting Liang, Bin Li and Fengxuan Han

Smart Materials in Medicine, 2024, 5, 488
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Injectable Hybrid Hydrogel Loaded with circFADS1 Microspheres for the Differentiation of Nucleus Pulposus Tissue-Derived Stem Cells and Intervertebral Disc Repair

Yang Zhang, Quanlai Zhao, Yifeng Li, Yu Zhang and Liang Xiao

Biomacromolecules, 2025, 26, 4936
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Injectable hydrogel induces regeneration of naturally degenerate human intervertebral discs in a loaded organ culture model

Hosni Cherif, Li Li, Joseph Snuggs, Xuan Li, Christopher Sammon, Jianyu Li, Lorne Beckman, Lisbet Haglund and Christine. L． Le Maitre

Acta Biomaterialia, 2024, 176, 201
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Reviving Intervertebral Discs: Treating Degeneration Using Advanced Delivery Systems

Hong Zhang, Xiaorong Yang, Yiheng Huang, Yue Li, Quan Hu, Qiaolin Wei, Weixing Xu, Weiguo Ding, Yong Guo and Jia-Wei Shen

Mol. Pharmaceutics, 2024, 21, 373
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Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation

Zhenyuan Wei, Han Ye, Yucai Li, Xiaoxiao Li, Yi Liu, Yujie Chen, Jiangming Yu, Jielin Wang and Xiaojian Ye

Acta Biomaterialia, 2024, 178, 50
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Sweat-adaptive adhesive hydrogel electronics enabled by dynamic hydrogen bond networks

Siheng Wang, Zhuomin Wang, Lei Zhang, Zhanqian Song, He Liu and Xu Xu

Chemical Engineering Journal, 2024, 492, 152290
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Designing hydrogel for application in spinal surgery

Rongpeng Dong, Shuang Zheng and Xueliang Cheng

Materials Today Bio, 2025, 31, 101536
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Robustly Injectable Tetra‐PEG Hydrogel Sealants for Annulus Fibrosus Repair

Guoke Tang, Yucai Li, Yi Liu, Lan Lin, Jielin Wang, Xing Wang and Xiaojian Ye

Adv Healthcare Materials, 2025, 14
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