Microsensor systems for cell metabolism – from 2D culture to organ-on-chip (2019–2024)

Johannes Dornhof, Jochen Kieninger, Stefan J. Rupitsch and Andreas Weltin

Lab Chip, 2025, 25, 1149
DOI: 10.1039/D4LC00437J

Vascularized human brain organoid on-chip

Sin Yen Tan, Xiaohan Feng, Lily Kwan Wai Cheng and Angela Ruohao Wu

Lab Chip, 2023, 23, 2693
DOI: 10.1039/D2LC01109C

Characterization of the oxygen properties of a hybrid glass chip designed for precise on chip oxygen control

Charlotte Bouquerel, Simon Dumas, Elias Abedelnour, Ester Simkova, Giacomo Gropplero, Linda Meddahi, Bertrand Cinquin, Michael Tatoulian, William César and Stephanie Descroix

Lab Chip, 2025, 25, 2449
DOI: 10.1039/D4LC01017E

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

Charlotte Bouquerel, Anastasiia Dubrova, Isabella Hofer, Duc T. T. Phan, Moencopi Bernheim, Ségolène Ladaigue, Charles Cavaniol, Danilo Maddalo, Luc Cabel, Fatima Mechta-Grigoriou, Claire Wilhelm, Gérard Zalcman, Maria Carla Parrini and Stéphanie Descroix

Lab Chip, 2023, 23, 3906
DOI: 10.1039/D3LC00531C

Engineering tumor spatial heterogeneity in vitro

Changchong Chen, Zixuan Zhao, Dong Hua Seah, Kenny Zhuoran Wu, Senthilkumar Mohanaselvi and Eliza Li Shan Fong

Advanced Drug Delivery Reviews, 2026, 229, 115757
DOI: 10.1016/j.addr.2025.115757

Improving tumor microenvironment assessment in chip systems through next-generation technology integration

Daniela Gaebler, Stephanie J. Hachey and Christopher C. W. Hughes

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1462293

Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment

Anastasiia Dubrova, Charles Cavaniol, Aurore Van de Walle, Paul Mathieu, Zoé Fusilier, Nader Yaacoub, Yoann Lalatonne, Stephanie Descroix and Claire Wilhelm

ACS Nano, 2025, 19, 19790
DOI: 10.1021/acsnano.5c02099

Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip

Irina Veith, Martin Nurmik, Arianna Mencattini, Isabelle Damei, Christine Lansche, Solenn Brosseau, Giacomo Gropplero, Stéphanie Corgnac, Joanna Filippi, Nicolas Poté, Edouard Guenzi, Anaïs Chassac, Pierre Mordant, Jimena Tosello, Christine Sedlik, Eliane Piaggio, Nicolas Girard, Jacques Camonis, Hamasseh Shirvani, Fathia Mami-Chouaib, Fatima Mechta-Grigoriou, Stéphanie Descroix, Eugenio Martinelli, Gérard Zalcman and Maria Carla Parrini

Cell Reports Medicine, 2024, 5, 101549
DOI: 10.1016/j.xcrm.2024.101549

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic and Stéphanie Descroix

Adv Healthcare Materials, 2026
DOI: 10.1002/adhm.202505483

Integrating machine learning and biosensors in microfluidic devices: A review

Gianni Antonelli, Joanna Filippi, Michele D’Orazio, Giorgia Curci, Paola Casti, Arianna Mencattini and Eugenio Martinelli

Biosensors and Bioelectronics, 2024, 263, 116632
DOI: 10.1016/j.bios.2024.116632

In silico model development and optimization of in vitro lung cell population growth

Amirmahdi Mostofinejad, David A. Romero, Dana Brinson, Alba E. Marin-Araujo, Aimy Bazylak, Thomas K. Waddell, Siba Haykal, Golnaz Karoubi, Cristina H. Amon and Gopinath Ponnusamy Manogaran

PLoS ONE, 2024, 19, e0300902
DOI: 10.1371/journal.pone.0300902