Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View

Tommaso Felicetti, Giuseppe Manfroni, Violetta Cecchetti and Rolando Cannalire

ChemMedChem, 2020, 15, 2391
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Dengue virus NS4B protein as a target for developing antivirals

Qingxin Li and Congbao Kang

Front. Cell. Infect. Microbiol., 2022, 12
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Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors

Bart Kesteleyn, Dorothée Bardiot, Jean-François Bonfanti, Benoît De Boeck, Olivia Goethals, Suzanne J. F. Kaptein, Bart Stoops, Erwin Coesemans, Jérôme Fortin, Philippe Muller, Frédéric Doublet, Gunter Carlens, Mohamed Koukni, Wim Smets, Pierre Raboisson, Patrick Chaltin, Kenny Simmen, Marnix Van Loock, Johan Neyts, Arnaud Marchand and Tim H. M. Jonckers

J. Med. Chem., 2023, 66, 8808
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Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes

Tommaso Felicetti, Chin Piaw Gwee, Maria Sole Burali, Kitti Wing Ki Chan, Sylvie Alonso, Maria Chiara Pismataro, Stefano Sabatini, Maria Letizia Barreca, Violetta Cecchetti, Subhash G. Vasudevan and Giuseppe Manfroni

European Journal of Medicinal Chemistry, 2023, 252, 115283
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Synthesis of a Potent Pan-Serotype Dengue Virus Inhibitor Having a Tetrahydrothienopyridine Core

Kevin Hung, Yugang Liu, Oliver Simon, Lei Zhang, Peichao Lu, Bryan K. S. Yeung, Christopher Sarko and Fumiaki Yokokawa

Synlett, 2022, 33, 464
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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

Stephanie A. Moquin, Oliver Simon, Ratna Karuna, Suresh B. Lakshminarayana, Fumiaki Yokokawa, Feng Wang, Chandra Saravanan, Jin Zhang, Craig W. Day, Katherine Chan, Qing-Yin Wang, Siyan Lu, Hongping Dong, Kah Fei Wan, Siew Pheng Lim, Wei Liu, Cheah Chen Seh, Yen-Liang Chen, Haoying Xu, David T. Barkan, Cyrille S. Kounde, Wei Lin Sandra Sim, Gang Wang, Hui-Quan Yeo, Bin Zou, Wai Ling Chan, Mei Ding, Jae-Geun Song, Min Li, Colin Osborne, Francesca Blasco, Christopher Sarko, David Beer, Ghislain M. C. Bonamy, Vito G. Sasseville, Pei-Yong Shi, Thierry T. Diagana, Bryan K. S. Yeung and Feng Gu

Sci. Transl. Med., 2021, 13
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