Anti-diabetic properties of brewer's spent yeast peptides. In vitro, in silico and ex vivo study after simulated gastrointestinal digestion

Marilin E. Aquino, Silvina R. Drago, Fermín Sánchez de Medina, Olga Martínez-Augustin and Raúl E. Cian

Food Funct., 2024, 15, 3778
DOI: 10.1039/D3FO04040B

In vivoandin silicostudy of antioxidant and anti-inflammatory effects on the liver-spleen axis of microencapsulated brewers’ spent grain peptides

María E. Oliva, Raúl E. Cian, María del Rosario Ferreira, Antonela G. Garzón, Silvina R. Drago and María E. D'Alessandro

Food Funct., 2023, 14, 5290
DOI: 10.1039/D2FO04104A

Valorization of brewing by-products: obtaining flavor-enhancing and antioxidant compounds from spent yeast

Antonela G. Garzón, Yanina Pavón, Marilin E. Aquino and Silvina R. Drago

Sustainable Food Technol., 2026, 4, 1728
DOI: 10.1039/D5FB00499C

Identification, molecular docking, and protective effects on H2O2-induced HEK-293 cell oxidative damage of antioxidant peptides from Pacific saury (Cololabis saira)

Junjia Luan, Lei Wang, Junnan Yang, Xuepeng Li, Jinxiang Wang, Fangchao Cui, Hongbo Mi, Yongxia Xu, Shumin Yi and Jianrong Li

Food Funct., 2023, 14, 160
DOI: 10.1039/D2FO02910C

Purification, identification and in silico studies of antioxidant, antidiabetogenic and antibacterial peptides obtained from sorghum spent grain hydrolysate

Antonela G. Garzón, Flávio F. Veras, Adriano Brandelli and Silvina R. Drago

LWT, 2022, 153, 112414
DOI: 10.1016/j.lwt.2021.112414

The health-promoting potential of peptides from brewing by-products: An up-to-date review

Rita Ribeiro-Oliveira, Zita E. Martins, Joana Beatriz Sousa, Isabel M.P.L.V.O. Ferreira and Carmen Diniz

Trends in Food Science & Technology, 2021, 118, 143
DOI: 10.1016/j.tifs.2021.09.019

Food-based uses of brewers spent grains: Current applications and future possibilities

Ajibola B. Oyedeji and Jianping Wu

Food Bioscience, 2023, 54, 102774
DOI: 10.1016/j.fbio.2023.102774

Identification and virtual screening of novel antioxidant peptides from brewing by-products and their cytoprotective effects against H2O2-induced oxidative stress

Zixuan Hu, Chunfeng Liu, Chengtuo Niu, Jinjing Wang, Feiyun Zheng and Qi Li

Food Bioscience, 2024, 58, 103686
DOI: 10.1016/j.fbio.2024.103686

Unlocking the hypolipidemic potential of bioactive peptides derived from probiotic fermented cattle, camel, goat, and sheep milk: a comprehensive investigation through in vitro,in silico, and molecular docking studies

Priti Mudgil, Feyisola Fisayo Ajayi, Aysha Saleh Alyafei, Pei-Gee Yap, Chee-Yuen Gan and Sajid Maqsood

Front. Sustain. Food Syst., 2024, 8
DOI: 10.3389/fsufs.2024.1443708

Residue profiles of peptides with cholesterol esterase and pancreatic lipase inhibitory activities through virtual screening and sequence analysis

Zhuangwei Zhang, Shuoqi Jiang, Yinzhe Li, Daming Xie and Jian-Xin Li

Food Chemistry, 2024, 460, 140708
DOI: 10.1016/j.foodchem.2024.140708

Recommendations for overcoming challenges in the diagnosis of lysosomal acid lipase deficiency

Pilar Giraldo, Laura López de Frutos and Jorge J Cebolla

Expert Opinion on Orphan Drugs, 2022, 10, 11
DOI: 10.1080/21678707.2022.2131393

Fabrication and Characterization of a Lipase Inhibition Protein Hydrolysate Derived from Baby Clam (Corbiculidae sp.) Meat

Tam Dinh Le Vo, Bao Chi Vo, Khoi Tri Nguyen and Hieu Hoang Nguyen

Waste Biomass Valor, 2026, 17, 469
DOI: 10.1007/s12649-025-03141-2

Comprehensive review of plant-derived anti-hyperlipidemia peptides: Production, anti-hyperlipidemia mechanism, and structure-activity relationship study

Liuyi Wei, Hao Wu, Xufeng Wang, Li Wen, Bo Cui and Yunhui Cheng

Food Chemistry, 2024, 461, 140715
DOI: 10.1016/j.foodchem.2024.140715

Isolation and identification of novel hemp seed protein-derived pancreatic lipase inhibitory peptides

Zhenghai Zhang, Jingyi Ge, Lianhui Wei, Jie Shi, Yanru Ji, Xiangyu Xing, Yu Shi and Yan Dong

Food Bioscience, 2025, 63, 105834
DOI: 10.1016/j.fbio.2025.105834

Microencapsulated bioactive peptides from brewer's spent grain promotes antihypertensive and antidiabetogenic effects on a hypertensive and insulin‐resistant rat model

Antonela G. Garzón, María del Rosario Ferreira, Raul E. Cian, Maria Eugenia Oliva, Maria Eugenia D'Alessandro and Silvina R. Drago

Journal of Food Biochemistry, 2022, 46
DOI: 10.1111/jfbc.14283

Lemon basil seed-derived peptide: Hydrolysis, purification, and its role as a pancreatic lipase inhibitor that reduces adipogenesis by downregulating SREBP-1c and PPAR-γ in 3T3-L1 adipocytes

Kittisak Kuptawach, Sajee Noitung, Anumart Buakeaw, Songchan Puthong, Ruengwit Sawangkeaw, Papassara Sangtanoo, Piroonporn Srimongkol, Onrapak Reamtong, Kiattawee Choowongkomon, Aphichart Karnchanatat and Fahrul Nurkolis

PLoS ONE, 2024, 19, e0301966
DOI: 10.1371/journal.pone.0301966

Bioaccessible bioactive compounds with antioxidant, antihypertensive, and neuroprotective properties from barley-malt beverages germinated under different conditions

Antonela G. Garzón, Franco Van de Velde and Silvina R. Drago

Journal of Food Composition and Analysis, 2025, 148, 108302
DOI: 10.1016/j.jfca.2025.108302

Valorization of brewing by-products as protein resources: Extraction, structural insights, functional properties, and value-added applications

Lin Deng, Haoyang Sun, Xiaomeng Li, Mohamed Salama, Xing Fu, Jian Su, Jia Zheng and Zhaoxia Cai

International Journal of Biological Macromolecules, 2025, 311, 144002
DOI: 10.1016/j.ijbiomac.2025.144002

Purification, identification and hypolipidemic activities of three novel hypolipidemic peptides from tea protein

Haoduo Ye, Yan Xu, Yunnan Sun, Benying Liu, Bingbing Chen, Guo Liu, Yong Cao and Jianyin Miao

Food Research International, 2023, 165, 112450
DOI: 10.1016/j.foodres.2022.112450

Study on the hypolipidemic activity of rapeseed protein-derived peptides

Feiyu Yang, Jiaqiang Huang, Haiyan He, Xingrong Ju, Ying Ji, Feng Deng, Zhigao Wang and Rong He

Food Chemistry, 2023, 423, 136315
DOI: 10.1016/j.foodchem.2023.136315

Precooked sorghum flour as proper vehicle of ACE‐I and DPP‐IV inhibitory sorghum peptides

Raúl E. Cian, Micaela Albarracín, Antonela G. Garzón and Silvina R. Drago

Int J of Food Sci Tech, 2022, 57, 4832
DOI: 10.1111/ijfs.15718

Research progress in lipid metabolic regulation of bioactive peptides

Wenshu Ma, Na Li, Luan Lin, Jiahui Wen, Chao Zhao and Fang Wang

Food Prod Process and Nutr, 2023, 5
DOI: 10.1186/s43014-022-00123-y

Ultrasonic pretreatment assisted enzymolysis for preparation of low molecular weight osteogenic collagen peptides: Kinetics, thermodynamics, and osteogenic activity

Liwei Qi, Lishuang Mao, Xiaojie Qin, Yujie Guo and Chunhui Zhang

Ultrasonics Sonochemistry, 2025, 120, 107525
DOI: 10.1016/j.ultsonch.2025.107525

Harvesting bioactive peptides from sustainable protein sources: Unveiling technological and functional properties through in silico analyses

Hale İnci Öztürk and Aysun Oraç

Food and Humanity, 2024, 2, 100294
DOI: 10.1016/j.foohum.2024.100294

Xanthan gum and pectin as beverage stabilizers reduce the digestive enzyme hydrolysis of antioxidant and antihypertensive peptides obtained from a brewery byproduct

A.G. Garzón, S.M. Pontoni, G. Mamone, S.R. Drago and R.E. Cian

Food Research International, 2024, 177, 113836
DOI: 10.1016/j.foodres.2023.113836

Hydrolyzed Proteins From Brewer's Spent Yeast as an Ingredient With Bioaccessible Antihypertensive and Neuroprotective Properties

Marilin E. Aquino, Silvina R. Drago, María I. Gomez and Raúl E. Cian

Sustainable Food Proteins, 2025, 3
DOI: 10.1002/sfp2.70034

Exploring the inhibitory potential of KPHs-AL-derived GLLF peptide on pancreatic lipase and cholesterol esterase activities

Fangfang Huang, Qingfei Dai, Kewei Zheng, Qingbao Ma, Yu Liu, Shuoqi Jiang, Wei Jiang and Xiaojun Yan

Food Chemistry, 2024, 439, 138108
DOI: 10.1016/j.foodchem.2023.138108

Exploring the potential applications of biopeptides from seaweeds, insects, and food wastes: mechanisms, utilisation, and industry implications

Thanh‐Do Le, Itthanan Suttikhana and Tolulope Joshua Ashaolu

Int J of Food Sci Tech, 2024, 59, 1260
DOI: 10.1111/ijfs.16920

Preparation and characterization of a sea cucumber collagen-derived peptide and the inhibition of pancreatic lipase

Zhe Xu, Jiale Chang, Zijin Qin, Hanxiong Liu, Xu Yan, Shuang Guan, Xiufang Dong, Jianping Wu and Tingting Li

Food Bioscience, 2025, 65, 106013
DOI: 10.1016/j.fbio.2025.106013

Identification of bioaccessible glycosylated neuroprotective peptides from brewer's spent yeast mannoproteins by in vitro and in silico studies

Marilin E. Aquino, Silvina R. Drago, Luis P. Schierloh and Raúl E. Cian

Food Research International, 2025, 209, 116188
DOI: 10.1016/j.foodres.2025.116188

Unmasking the efficacy of Skipjack Tuna ( Katsuwonus Pelamis ) dark muscle hydrolyzate in lipid regulation: a promising component for functional food

Fangfang Huang, Qingfei Dai, Kewei Zheng, Qingbao Ma, Yu Liu, Wei Jiang and Xiaojun Yan

International Journal of Food Properties, 2023, 26, 3014
DOI: 10.1080/10942912.2023.2267788

A comprehensive review on the pancreatic lipase inhibitory peptides: A future anti-obesity strategy

Tan Yong Chia, Chee-Yuen Gan, Muhammad Hakimin Shafie, Pei Gee Yap, Ainolsyakira Mohd Rodhi, Ashfaq Ahmad, Vikneswaran Murugaiyah, Mohammed H Abdulla and Edward James Johns

ELECTRON J GEN MED, 2023, 20, em470
DOI: 10.29333/ejgm/12943

Bioactive Plant Peptides: Physicochemical Features, Structure-Function Insights and Mechanism of Action

Sara Avilés-Gaxiola, Israel García-Aguiar, Luis Alfonso Jiménez-Ortega, Erick Paul Gutiérrez-Grijalva and José Basilio Heredia

Molecules, 2025, 30, 3683
DOI: 10.3390/molecules30183683

Effects of agar-carrageenan wall materials and core-to-wall material ratio on physicochemical properties and in vitro bioaccessibility of microencapsulated bioactive peptides

A.G. Garzón, R.E. Cian and S.R. Drago

Food Hydrocolloids, 2023, 139, 108570
DOI: 10.1016/j.foodhyd.2023.108570

Enzymolysis kinetics, thermodynamics and structural property of brewer’s spent grain protein pretreated with ultrasound

Qing Li, Huirong Yang, Teodora Emilia Coldea, Mogens Larsen Andersen, Wanying Li and Haifeng Zhao

Food and Bioproducts Processing, 2022, 132, 130
DOI: 10.1016/j.fbp.2022.01.001

Recent Progress in Distiller’s Grains: Chemical Compositions and Biological Activities

Ran He, Yubo Yang, Yongsu Li, Minghua Yang, Lingyi Kong and Fan Yang

Molecules, 2023, 28, 7492
DOI: 10.3390/molecules28227492

Synthesis and Characterization of Short α and β-Mixed Peptides with Excellent Anti-Lipase Activities

Naeem Ahmed, Sabahat Asif, Muhammad Arfan, Qaiser Mahmood, Amjad Islam, Mansour K. Gatasheh and Muhammad Zia

Molecules, 2024, 29, 765
DOI: 10.3390/molecules29040765

Insights into rapid screening and molecular mechanism of novel Rosa roxburghii seeds pancreatic lipase/cholesterol esterase inhibitory peptides: a combined in silico and in vitro perspective

Hao Yin, Jiangxiong Zhu, Yu Zhong, Danfeng Wang, Yun Deng, Yongli Jiang, Linnan Yang and Lutao Gao

Food Science and Human Wellness, 2025, 14, 9250163
DOI: 10.26599/FSHW.2024.9250163

Hexagonal plate ultrasound pretreatment on the correlation between soy protein isolate structure and cholesterol-lowering activity of peptides, and protein's enzymolysis kinetics, thermodynamics

Wen Chen, Fan Yang, Haining Xu, Jiayin Pan, Jun Liu, Mokhtar Dabbour, Benjamin Kumah Mintah, Liurong Huang, Chunhua Dai, Haile Ma and Ronghai He

International Journal of Biological Macromolecules, 2024, 258, 128897
DOI: 10.1016/j.ijbiomac.2023.128897

Lipid-lowering effect of microencapsulated peptides from brewer's spent grain in high-sucrose diet-fed rats

M.R. Ferreira, A.G. Garzón, M.E. Oliva, R.E. Cian, S.R. Drago and M.E. D'Alessandro

Food Bioscience, 2022, 49, 101981
DOI: 10.1016/j.fbio.2022.101981

In silico bioactivity analysis of peptide fractions derived from brewer's spent grain hydrolysates

J. E. Aguilar‐Toalá, Y. Cruz‐Narváez, D. Quintanar‐Guerrero, Andrea M. Liceaga and M. L. Zambrano‐Zaragoza

Int J of Food Sci Tech, 2024, 59, 2804
DOI: 10.1111/ijfs.17044

Identification and synthesis of selective cholesterol esterase inhibitor using dynamic combinatorial chemistry

Shuang Zhao, Yao Wu and Lei Hu

Bioorganic Chemistry, 2022, 119, 105520
DOI: 10.1016/j.bioorg.2021.105520

Emerging proteins as precursors of bioactive peptides/hydrolysates with health benefits

Shuguang Wang, Mouming Zhao, Hongbing Fan and Jianping Wu

Current Opinion in Food Science, 2022, 48, 100914
DOI: 10.1016/j.cofs.2022.100914

Production of neuroprotective compounds from barley (Hordeum vulgare L.) germinated under different conditions during the malting process

Raúl E Cian, Antonela G Garzón, Micaela Albarracín and Silvina R Drago

International Journal of Food Science and Technology, 2025, 60
DOI: 10.1093/ijfood/vvae033

Kinetic and thermodynamic-based studies on the interaction mechanism of novel R. roxburghii seed peptides against pancreatic lipase and cholesterol esterase

Hao Yin, Jiangxiong Zhu, Yu Zhong, Danfeng Wang and Yun Deng

Food Chemistry, 2024, 447, 139006
DOI: 10.1016/j.foodchem.2024.139006

Identification and molecular binding mechanism of novel pancreatic lipase and cholesterol esterase inhibitory peptides from heat-treated adzuki bean protein hydrolysates

Qingyu Zhao, Yimeng Fan, Liangxing Zhao, Yiqing Zhu, Yuanrong Jiang, Jie Gu, Yong Xue, Zhihui Hao and Qun Shen

Food Chemistry, 2024, 439, 138129
DOI: 10.1016/j.foodchem.2023.138129

Pancreatic lipase inhibitory effects of peptides derived from sesame proteins: In silico and in vitro analyses

Xinyi Wang, Xin Ai, Zehui Zhu, Mingxin Zhang, Fei Pan, Zichen Yang, Ou Wang, Liang Zhao and Lei Zhao

International Journal of Biological Macromolecules, 2022, 222, 1531
DOI: 10.1016/j.ijbiomac.2022.09.259

Bio-synthesis, purification and structural analysis of Cyclosporine-A produced by Tolypocladium inflatum with valorization of agro-industrial wastes

Fereshteh Falah, Ali Samie, Seyed Ali Mortazavi, Abolghasem Danesh, Farideh Tabatabaei Yazdi and Mohammad Ramezani

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-63110-y

Lentil Flours as Sustainable Source of Proteins for the Food Industry

S. M. Pontoni, A.G. Garzón, G. D. Heinen and S.R. Drago

Sustainable Food Proteins, 2025, 3
DOI: 10.1002/sfp2.70027

Gastrointestinal digestion and colonic fermentation of brewer's spent yeast peptides modulate their antioxidant properties and effect on intestinal barrier

Marilin E. Aquino, Fermín Sánchez de Medina, Silvina R. Drago, Olga Martínez-Augustin and Raúl E. Cian

Food Bioscience, 2024, 60, 104294
DOI: 10.1016/j.fbio.2024.104294

Technological role and metabolic profile of two probiotic EPS-producing strains with potential application in yoghurt: Impact on rheology and release of bioactive peptides

Elisa C. Ale, Rodrigo A. Ibáñez, Daniel J. Wilbanks, Guillermo H. Peralta, Fatma D. Ceylan, Ana G. Binetti, Bradley W. Bolling and John A. Lucey

International Dairy Journal, 2023, 137, 105533
DOI: 10.1016/j.idairyj.2022.105533

Multiple Bioactivities of Peptides from Hydrolyzed Misgurnus anguillicaudatus

Baojie Dou, Xudong Wu, Zihan Xia, Guanghao Wu, Quanyou Guo, Mingsheng Lyu and Shujun Wang

Molecules, 2023, 28, 2589
DOI: 10.3390/molecules28062589

Hairless canary seeds (Phalaris canariensis L.) as a potential source of antioxidant, antihypertensive, antidiabetic, and antiobesity biopeptides

U. C. Urbizo-Reyes, J. E. Aguilar-Toalá and A. M. Liceaga

Food Prod Process and Nutr, 2021, 3
DOI: 10.1186/s43014-020-00050-w

Identification, characterization and hypolipidemic effect of novel peptides in protein hydrolysate from Protaetia brevitarsis larvae

Zong-Qi Zhang, Xin-Rui Ren, Jin Geng, Si-Cong Chen, Qing-Lei Wang, Chun-Qin Liu, Jin-Hua Xiao and Da-Wei Huang

Food Research International, 2024, 176, 113813
DOI: 10.1016/j.foodres.2023.113813

Casein Glycomacropeptide Regulates Gene Expression in Intestinal Epithelial Cells: Effect of Simulated Gastrointestinal Digestion and Peptide Microencapsulation

Raúl E. Cian, Mireia Tena-Garitaonaindia, Fermín Sánchez de Medina and Olga Martínez-Augustin

J. Agric. Food Chem., 2025, 73, 4105
DOI: 10.1021/acs.jafc.4c10146

Recent Advances on Bioactive Peptide Fractionation Methods

Mingming Kan, Zhi Yin Ter, Noor-Soffalina Sofian-Seng, Lee Sin Chang, Shuai Wang and Seng Joe Lim

Food Bioprocess Technol, 2025, 18, 7032
DOI: 10.1007/s11947-025-03893-8