Clinically used drug arsenic trioxide targets XIAP and overcomes apoptosis resistance in an organoid-based preclinical cancer model

Liwa Shi, Jing Lu, Xin Xia, Xue Liu, Hongyan Li, Xinghua Li, Jun Zhu, Xiaofeng Li, Hongzhe Sun and Xinming Yang

Chem. Sci., 2024, 15, 8311
DOI: 10.1039/D4SC01294A

Arsenic compounds in cancer therapy: mechanistic insights and antitumor activity

Xian Zhang, Yujiao Liu, Shuangnian Xu and Dongdong Zhang

Biochemical Pharmacology, 2025, 240, 117093
DOI: 10.1016/j.bcp.2025.117093

Macrophage secretory IL-1β promotes docetaxel resistance in head and neck squamous carcinoma via SOD2/CAT-ICAM1 signaling

Ching-Yun Hsieh, Ching-Chan Lin, Yu-Wen Huang, Jong-Hang Chen, Yung-An Tsou, Ling-Chu Chang, Chi-Chen Fan, Chen-Yuan Lin and Wei-Chao Chang

JCI Insight, 2022, 7
DOI: 10.1172/jci.insight.157285

Interplay between RNA Viruses and Promyelocytic Leukemia Nuclear Bodies

Sabari Nath Neerukonda

Veterinary Sciences, 2021, 8, 57
DOI: 10.3390/vetsci8040057

Torsemide increases arsenic concentrations by inhibition of multidrug resistance protein 4 in arsenic trioxide treated acute promyelocytic leukemia patients

Jian Lv, Mengliang Wu, Chunrong Pang, Rui Duan, Hong Zhang, Shuo Tian, Haixia Yang and Xin Hai

Biomedicine & Pharmacotherapy, 2023, 163, 114858
DOI: 10.1016/j.biopha.2023.114858

7,8-Dihydroxyflavone enhances the chemosensitivity of hepatocellular carcinoma cells to arsenic trioxide by disrupting mitochondrial oxidative phosphorylation

Dan-dan Guo, Zhen Tian, Ru-jin Liang, Ting-ting Tan, Yu-wei Hu, Hua Zhu, Jing Zhao and Peng-zhou Hang

Pharmacological Research - Modern Chinese Medicine, 2025, 17, 100693
DOI: 10.1016/j.prmcm.2025.100693

Facile Microwave-Assisted Biosynthesis of Arsenic Nanoparticles and Evaluation their Antioxidant Properties and Cytotoxic Effects: A Preliminary in Vitro Study

Naghmeh Satarzadeh, Mojtaba Shakibaie, Mahboubeh Adeli-Sardou, Fereshteh Jabari-Morouei, Hamid Forootanfar and Amin Sadeghi-Dousari

J Clust Sci, 2023, 34, 1831
DOI: 10.1007/s10876-022-02356-w

Arsenic removal from water by nanofiltration membrane: potentials and limitations

Chabi Noël Worou, Zhong-Lin Chen and Taofic Bacharou

Water Practice and Technology, 2021, 16, 291
DOI: 10.2166/wpt.2021.018

Metal‐based smart nanosystems in cancer immunotherapy

Ying Luo, Xiaojing He, Qianying Du, Lian Xu, Jie Xu, Junrui Wang, Wenli Zhang, Yixin Zhong, Dajing Guo, Yun Liu and Xiaoyuan Chen

Exploration, 2024, 4
DOI: 10.1002/EXP.20230134

Development of Metal-Based Drugs and Application in Clinical Treatment

Yi Ming Shao, Bold Sharavyn, Ping Huang, Hua Naranmandura and Qian Qian Wang

NPJ, 2022, 12
DOI: 10.2174/2210315511666210512025010

The relevance of arsenic speciation analysis in health & medicine

Rajbinder K. Virk, Roobee Garla, Naveen Kaushal, Mohinder P. Bansal, Mohan L. Garg and Biraja P. Mohanty

Chemosphere, 2023, 316, 137735
DOI: 10.1016/j.chemosphere.2023.137735

Efficacy and safety of decitabine combined with arsenic trioxide in elderly high-risk myelodysplastic neoplasm patients: a retrospective study

Jianzhong Yang

Hematology, 2025, 30
DOI: 10.1080/16078454.2025.2485493

Type 2 diabetes affects arsenic metabolism via transporters in arsenic trioxide treated acute promyelocytic leukemia patients

Mengliang Wu, Chunrong Pang, Shengwen Lu, Thomas H. Hostetter and Xin Hai

Environmental Toxicology and Pharmacology, 2023, 100, 104142
DOI: 10.1016/j.etap.2023.104142

Low-dose arsenic trioxide inhibits pancreatic stellate cell activation via LOXL3 expression to enhance immunotherapy in pancreatic cancer

Yue Zhao, Yunlong Li, Jinmao Zou, Tairan Guo, Ziyi Zhong, Yaqing Li, Shaojie Chen, Jiajia Li, Kaihong Huang, Guoda Lian and Yuzhou Huang

Br J Cancer, 2024, 131, 1928
DOI: 10.1038/s41416-024-02880-8

Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors

Meiyu Qu, Qiangqiang He, Hangyang Bao, Xing Ji, Tingyu Shen, Muhammad Qasim Barkat, Ximei Wu and Ling-Hui Zeng

Journal of Pharmaceutical Analysis, 2024, 14, 100957
DOI: 10.1016/j.jpha.2024.02.011

Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia

Ashley Ott, Vinayak Venkataraman, Yousef R. Badran, Rose Goldman, Smiljana Spasic, Darshali A. Vyas, Philip Amrein, Steven McAfee, Andrew Brunner, Amir T. Fathi and Rupa Narayan

Clinical Case Reports, 2021, 9
DOI: 10.1002/ccr3.4115

Paradoxical effects of arsenic in the lungs

Caixia Ren, Yang Zhou, Wenwen Liu and Qi Wang

Environ Health Prev Med, 2021, 26
DOI: 10.1186/s12199-021-00998-2

Efficacy of oral tetra-arsenic tetra-sulfide maintenance therapy for ovarian cancer: a single-center observational study

Yingchao Yang, Xiaoping Li, Xuelian Song, Lijun Zhao, Yue Wang, Yan Wu and Lihui Wei

gocm, 2025, 5, e000162
DOI: 10.1136/gocm-2024-000162

New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies

J. Nguyen, P.S. Saffari, A.S. Pollack, S. Vennam, X. Gong, R.B. West and J.R. Pollack

J Dent Res, 2022, 101, 1517
DOI: 10.1177/00220345221100773

Arsenic Trioxide: Pharmacological Applications

German Madrigal Redondo, María Fernanda Rojas Salas, Rolando Vargas Zúñiga, Daniela González Corrales, Celeste Ortega Monge, Pamela Ceciliano Porras, Mariana Cerdas Delgado and Jeison Montero Rivera

Vitae, 2023, 30
DOI: 10.17533/udea.vitae.v30n1a349001

Arsenic trioxide synergistically promotes the antileukaemic activity of venetoclax by downregulating Mcl-1 in acute myeloid leukaemia cells

Hyunsoo Cho, Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong and Yoo Hong Min

Exp Hematol Oncol, 2021, 10
DOI: 10.1186/s40164-021-00221-6

Subcellular Partitioning of Arsenic Trioxide Revealed by Label-Free Imaging

Song Huang, Kai Chen, Jong-Kai Leung, Paul Guagliardo, Weihua Chen, Wenxin Song, Peta Clode, Jiake Xu, Stephen G. Young and Haibo Jiang

Anal. Chem., 2022, 94, 13889
DOI: 10.1021/acs.analchem.2c02770

The landscape of novel strategies for acute myeloid leukemia treatment: Therapeutic trends, challenges, and future directions

Ri Han Wu, Chen Ying Zhu, Pei Han Yu, Yafang Ma, Liaqat Hussain, Hua Naranmandura and Qian Qian Wang

Toxicology and Applied Pharmacology, 2023, 473, 116585
DOI: 10.1016/j.taap.2023.116585

A Tumor Homing Peptide-Linked Arsenic Compound Inhibits Pancreatic Cancer Growth and Enhances the Inhibitory Effect of Gemcitabine

Hong He, Chelsea Dumesny, Judith A. Carrall, Carolyn T. Dillon, Katja I. de Roo, Mal Eutick, Li Dong, Graham S. Baldwin and Mehrdad Nikfarjam

IJMS, 2024, 25, 11366
DOI: 10.3390/ijms252111366

AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer

Yi Li, Wenyan She, Xiaoran Xu, Yixin Liu, Xinyu Wang, Sheng Tian, Shiyi Li, Miao Wang, Chaochao Yu, Pan Liu, Tianhe Huang and Yongchang Wei

J. Zhejiang Univ. Sci. B, 2023, 24, 232
DOI: 10.1631/jzus.B2200351

Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond

Yasen Maimaitiyiming, Qian Qian Wang, Chih-Hung Hsu and Hua Naranmandura

Toxicology and Applied Pharmacology, 2020, 406, 115212
DOI: 10.1016/j.taap.2020.115212

Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1

Yixin Liu, Wenyan She, Yi Li, Miao Wang, Yin Liu, Biao Ning, Tianzi Xu, Tianhe Huang and Yongchang Wei

J Transl Med, 2023, 21
DOI: 10.1186/s12967-022-03862-1

Preparation of Folic acid@Arsenic Nanoparticles and Evaluation of their Antioxidant Properties and Cytotoxic Effects

Mojtaba Shakibaie, Maryam Faraji, Mehdi Ranjbar, Mahboubeh Adeli-Sardou, Fereshteh Jabari-Morouei and Hamid Forootanfar

PNT, 2024, 12, 45
DOI: 10.2174/2211738511666230507175710

The Redox Paradox: Cancer’s Double-Edged Sword for Malignancy and Therapy

Jyotsna Suresh Ranbhise, Manish Kumar Singh, Songhyun Ju, Sunhee Han, Hyeong Rok Yun, Sung Soo Kim and Insug Kang

Antioxidants, 2025, 14, 1187
DOI: 10.3390/antiox14101187

Galbanic Acid Improves Accumulation and Toxicity of Arsenic Trioxide in MT-2 Cells

Maryam Mahdifar, Fatemeh B. Rassouli, Mehrdad Iranshahi, Sajad Goudarzi, Marzieh Golizadeh and Houshang Rafatpanah

ACAMC, 2023, 23, 699
DOI: 10.2174/1871520622666220722105802

Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia

Qian Qian Wang, Hao Ying Hua, Hua Naranmandura and Hong-Hu Zhu

Toxicology and Applied Pharmacology, 2020, 409, 115299
DOI: 10.1016/j.taap.2020.115299

Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells

Zaynab Fatfat, Maamoun Fatfat and Hala Gali-Muhtasib

WJCO, 2021, 12, 522
DOI: 10.5306/wjco.v12.i7.522

Can arsenic do anything good? Arsenic nanodrugs in the fight against cancer – last decade review

Izabela Komorowicz and Anetta Hanć

Talanta, 2024, 276, 126240
DOI: 10.1016/j.talanta.2024.126240

Antipyretic and Anti-inflammatory Effects of Sanchen Pediatric Antipyretic Paste

Li De Su, Hurilebater, Lu Men Chao, Sanchula, Dong Yu, Amguleng, Jian Hui Hao and Xin Li

NPJ, 2024, 14
DOI: 10.2174/0122103155253664231010070548

The application of arsenic trioxide in cancer: An umbrella review of meta-analyses based on randomized controlled trials

Jixin Chen, Shuqi Chen, Huiyan Luo, Wanyin Wu and Sumei Wang

Journal of Ethnopharmacology, 2023, 316, 116734
DOI: 10.1016/j.jep.2023.116734

Arsenic Trioxide (ATOIII) Induces NAD(P)H Quinone Oxidoreductase 1 (NQO1) Expression in Hepatic and Extrahepatic Tissues of C57BL/6 Mice

Sara R. El-Mahrouk, Mahmoud A. El-Ghiaty, Mohammed A. Alqahtani and Ayman O. S. El-Kadi

Chem. Res. Toxicol., 2024, 37, 2040
DOI: 10.1021/acs.chemrestox.4c00422

Arsenic trioxide sensitizes pancreatic cancer cells to gemcitabine through downregulation of the TIMP1/PI3K/AKT/mTOR axis

Zhenfeng Tian, Ying Tan, Xingyi Lin, Mingxin Su, Lele Pan, Lijun Lin, Guangsheng Ou and Yinting Chen

Translational Research, 2023, 255, 66
DOI: 10.1016/j.trsl.2022.11.007

Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date

Meng Yan, Hao Wang, Rui Wei and Wenwen Li

Arch. Pharm. Res., 2024, 47, 249
DOI: 10.1007/s12272-023-01481-y

Electrochemiluminescence assay for the impact of Ganoderma lucidum polysaccharides on resisting arsenic-induced apoptosis

Gen Liu, Yahui Ji, Chenchen Lei and Hui Gao

International Journal of Biological Macromolecules, 2024, 278, 134906
DOI: 10.1016/j.ijbiomac.2024.134906

Maximizing arsenic trioxide's anticancer potential: Targeted nanocarriers for solid tumor therapy

Shiqi Yang, Faisal Raza, Kunwei Li, Yujiao Qiu, Jing Su and Mingfeng Qiu

Colloids and Surfaces B: Biointerfaces, 2024, 241, 114014
DOI: 10.1016/j.colsurfb.2024.114014

Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment

Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X. Chris Le, Qiuquan Wang and Xiaowen Yan

J. Med. Chem., 2024, 67, 5458
DOI: 10.1021/acs.jmedchem.3c02076