Hyphenated MS-based targeted approaches in metabolomics

O. Begou, H. G. Gika, I. D. Wilson and G. Theodoridis

Analyst, 2017, 142, 3079
DOI: 10.1039/C7AN00812K

Effects of harvesting and extraction methods on metabolite recovery from adherently growing mammalian cells

Yun Luo, Ningbo Geng, Baoqin Zhang, Jiping Chen and Haijun Zhang

Anal. Methods, 2020, 12, 2491
DOI: 10.1039/C9AY02753J

New instrumentation for large-scale quantitative analysis of components spanning a wide polarity range by column-switching hydrophilic interaction chromatography-turbulent flow chromatography-reversed phase liquid chromatography-tandem mass spectrometry

Qingqing Song, Yunfang Zhao, Xiaojia Chen, Jun Li, Peng Li, Yong Jiang, Yitao Wang, Yuelin Song and Pengfei Tu

RSC Adv., 2017, 7, 31838
DOI: 10.1039/C7RA03788K

An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry

Lihua Zuo, Liwei Liu, Yantao Yang, Jie Yang, Min Chen, Huafeng Zhang, Jian Kang, Xiaojian Zhang, Jiabo Wang and Zhi Sun

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.610226

Metabolomic Analysis Reveals the Diversity of Defense Metabolites in Nine Cereal Crops

Sishu Huang, Xindong Li, Kejin An, Congping Xu, Zhenhuan Liu, Guan Wang, Huanteng Hou, Ran Zhang, Yutong Wang, Honglun Yuan and Jie Luo

Plants, 2025, 14, 629
DOI: 10.3390/plants14040629

Characterization and Determination of 13C-Labeled Nonessential Amino Acids in a 13C5-Glutamine Isotope Tracer Experiment with a Mass Spectrometry Strategy Combining Parallel Reaction Monitoring and Multiple Reaction Monitoring

Yuanyuan Zheng, Hongzhi Zhao, Man Tong, Lin Zhu, Stephanie Ma and Zongwei Cai

Anal. Chem., 2021, 93, 13564
DOI: 10.1021/acs.analchem.1c02554

Discovery of metabolite profiles of metabolic syndrome using untargeted and targeted LC–MS based lipidomics approach

Li-li Gong, Song Yang, Wen Zhang, Fei-fei Han, Ya-li Lv, Ling-ling Xuan, He Liu and Li-hong Liu

Journal of Pharmaceutical and Biomedical Analysis, 2020, 177, 112848
DOI: 10.1016/j.jpba.2019.112848

Targeted Chiral Metabolomics of D-Amino Acids: Their Emerging Role as Potential Biomarkers in Neurological Diseases with a Focus on Their Liquid Chromatography–Mass Spectrometry Analysis upon Chiral Derivatization

Cinzia Lella, Liam Nestor, Dimitri De Bundel, Yvan Vander Heyden and Ann Van Eeckhaut

IJMS, 2024, 25, 12410
DOI: 10.3390/ijms252212410

The Impact of Systems Biology on Bioprocessing

Kate Campbell, Jianye Xia and Jens Nielsen

Trends in Biotechnology, 2017, 35, 1156
DOI: 10.1016/j.tibtech.2017.08.011

Mechanistic Study of the Deuterium Effect in Chromatographic Separation for Chemical-Tagging Metabolomics and Its Application to Biomarker Discovery in Metabolic Dysfunction-Associated Steatohepatitis

Yugo Akioka, Tomoya Higuchi, Takahiro Takayama, Mayuko Ichimura-Shimizu, Koichi Tsuneyama and Koichi Inoue

Anal. Chem., 2025, 97, 8931
DOI: 10.1021/acs.analchem.5c00289

Simultaneous Profiling and Holistic Comparison of the Metabolomes among the Flower Buds of Panax ginseng, Panax quinquefolius, and Panax notoginseng by UHPLC/IM-QTOF-HDMSE-Based Metabolomics Analysis

Li Jia, Tiantian Zuo, Chunxia Zhang, Weiwei Li, Hongda Wang, Ying Hu, Xiaoyan Wang, Yuexin Qian, Wenzhi Yang and Heshui Yu

Molecules, 2019, 24, 2188
DOI: 10.3390/molecules24112188

Quantification of Cytokinins Using High-Resolution Accurate-Mass Orbitrap Mass Spectrometry and Parallel Reaction Monitoring (PRM)

Anna Kisiala, Shrikaar Kambhampati, Naomi L. Stock, Megan Aoki and R. J. Neil Emery

Anal. Chem., 2019, 91, 15049
DOI: 10.1021/acs.analchem.9b03728

Analytical quality control in targeted lipidomics: Evaluating the performance of commercial plasma as a surrogate for pooled study samples

Alanah Grant-St James, Aude-Claire Lee, Alex J. Lee, Julien Wist, Ferdous Sohel, Kok Wai Wong, Bu B. Yeap, Ruey Leng Loo, Amanda Henry, Daniella Susic, Emad El-Omar, Jeremy K. Nicholson, Elaine Holmes, Luke Whiley and Nicola Gray

Analytica Chimica Acta, 2025, 1365, 344225
DOI: 10.1016/j.aca.2025.344225

Application of a proton quantitative nuclear magnetic resonance spectroscopy method for the determination of actinodaphnine in Illigera aromatica and Illigera henryi

Jian-Wei Dong, Xue-Jiao Li, Jun-You Shi and Kai-Quan Liu

J Nat Med, 2019, 73, 312
DOI: 10.1007/s11418-018-1264-0

A large-scale, targeted metabolomics method for the analysis and quantification of metabolites in human plasma via liquid chromatography-mass spectrometry

Teresa S. McMillen, Andrew Leslie, Kenneth Chisholm, Susanne Penny, Jeffrey Gallant, Alejandro Cohen, Arik Drucker, James P. Fawcett and Devanand M. Pinto

Analytica Chimica Acta, 2023, 1279, 341791
DOI: 10.1016/j.aca.2023.341791

Development and Validation of Targeted Metabolomics Methods Using Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) for the Quantification of 235 Plasma Metabolites

Kangkang Xu, Franz Berthiller, Barbara U. Metzler-Zebeli and Heidi E. Schwartz-Zimmermann

Molecules, 2025, 30, 706
DOI: 10.3390/molecules30030706

Metabolomic Profiling of Human Urine Samples Using LC-TIMS-QTOF Mass Spectrometry

Cristina Di Poto, Xiang Tian, Xuejun Peng, Heino M. Heyman, Matthias Szesny, Sonja Hess and Lisa H. Cazares

J. Am. Soc. Mass Spectrom., 2021, 32, 2072
DOI: 10.1021/jasms.0c00467

Photoperiod-Dependent Nutrient Accumulation in Rice Cultivated in Plant Factories: A Comparative Metabolomic Analysis

Jingyao Yu, Yu Yang, Lanjun Luo, Fang Feng, Sana Saeed, Jie Luo, Chuanying Fang, Junjie Zhou and Kang Li

Foods, 2024, 13, 1544
DOI: 10.3390/foods13101544

Acylcarnitines: Can They Be Biomarkers of Diabetic Nephropathy?

Xiaodie Mu, Min Yang, Peiyao Ling, Aihua Wu, Hua Zhou and Jingting Jiang

DMSO, 2022, Volume 15, 247
DOI: 10.2147/DMSO.S350233

Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery

Nikhil Titkare, Sachin Chaturvedi, Sapan Borah and Nitish Sharma

Biomedical Chromatography, 2024, 38
DOI: 10.1002/bmc.6019

Saliva metabolomics: a non-invasive frontier for diagnosing and managing oral diseases

Xinyuan Zhao, Xu Chen, Ye Lu, Zihao Zhou, Pei Lin, Yunfan Lin, Shen Hu and Li Cui

J Transl Med, 2025, 23
DOI: 10.1186/s12967-025-06587-z

Recent advances in traditional Chinese medicine metabolism: Sample pre-treatment, MS-oriented analytical strategies and typical applications

Li-li Hong, Dian-xin Cui, Hong-da Wang, Qi Jing, Xue Li, Ying Hu, Yi-qing Yao, Xiu-mei Gao, De-an Guo and Wen-zhi Yang

TrAC Trends in Analytical Chemistry, 2025, 189, 118269
DOI: 10.1016/j.trac.2025.118269

Integration of genomics and metabolomics for prioritization of rare disease variants: a 2018 literature review

Emma Graham, Jessica Lee, Magda Price, Maja Tarailo‐Graovac, Allison Matthews, Udo Engelke, Jeffrey Tang, Leo A. J. Kluijtmans, Ron A. Wevers, Wyeth W. Wasserman, Clara D. M. van Karnebeek and Sara Mostafavi

J of Inher Metab Disea, 2018, 41, 435
DOI: 10.1007/s10545-018-0139-6

Challenges in Metabolomics-Based Tests, Biomarkers Revealed by Metabolomic Analysis, and the Promise of the Application of Metabolomics in Precision Medicine

Alessandro Di Minno, Monica Gelzo, Marianna Caterino, Michele Costanzo, Margherita Ruoppolo and Giuseppe Castaldo

IJMS, 2022, 23, 5213
DOI: 10.3390/ijms23095213

UPLC-ESI-MRM/MS for Absolute Quantification and MS/MS Structural Elucidation of Six Specialized Pyranonaphthoquinone Metabolites From Ventilago harmandiana

Suphitcha Limjiasahapong, Khwanta Kaewnarin, Narumol Jariyasopit, Sakchai Hongthong, Narong Nuntasaen, Jonathan L. Robinson, Intawat Nookaew, Yongyut Sirivatanauksorn, Chutima Kuhakarn, Vichai Reutrakul and Sakda Khoomrung

Front. Plant Sci., 2021, 11
DOI: 10.3389/fpls.2020.602993

Impact of Gut Microbiome Modulating Interventions on Fecal Metabolome of Infants: A Systematic Review and Quality Assessment

Gaute Hovde Bø, Rolf Simon Härmä, Claus Klingenberg and Veronika Kuchařová Pettersen

Proteomics, 2025
DOI: 10.1002/pmic.202400150

Effects of Dufulin on Oxidative Stress and Metabolomic Profile of Tubifex

Yile Yu, Yuxin Zhu, Jing Yang, Wentao Zhu, Zhiqiang Zhou and Renke Zhang

Metabolites, 2021, 11, 381
DOI: 10.3390/metabo11060381

Fully-Automated Systems and the Need for Global Approaches Should Exhort Clinical Labs to Reinvent Routine Ms Analysis?

Bertrand Rochat

Bioanalysis, 2018, 10, 1129
DOI: 10.4155/bio-2018-0074

SWATHtoMRM: Development of High-Coverage Targeted Metabolomics Method Using SWATH Technology for Biomarker Discovery

Haihong Zha, Yuping Cai, Yandong Yin, Zhuozhong Wang, Kang Li and Zheng-Jiang Zhu

Anal. Chem., 2018, 90, 4062
DOI: 10.1021/acs.analchem.7b05318

Chemical characteristics vectors map the chemical space of natural biomes from untargeted mass spectrometry data

Pilleriin Peets, Aristeidis Litos, Kai Dührkop, Daniel R. Garza, Justin J. J. van der Hooft, Sebastian Böcker and Bas E. Dutilh

J Cheminform, 2025, 17
DOI: 10.1186/s13321-025-01031-2

Semi-Targeted Metabolomics to Validate Biomarkers of Grape Downy Mildew Infection Under Field Conditions

Kévin Billet, Magdalena Anna Malinowska, Thibaut Munsch, Marianne Unlubayir, Sophie Adler, Guillaume Delanoue and Arnaud Lanoue

Plants, 2020, 9, 1008
DOI: 10.3390/plants9081008

Metabolomics: Unveiling biological matrices in precision nutrition and health

Bruna Lima Chechin Catussi, Edson Guimarães Lo Turco, Dirceu Mendes Pereira, Rafael Matheus Nunes Teixeira, Bárbara Prestes Castro and Irineu Francisco Delfino Massaia

Clinical Nutrition ESPEN, 2024, 64, 314
DOI: 10.1016/j.clnesp.2024.10.148

Metabolic regulation of prostate cancer heterogeneity and plasticity

Claudia Peitzsch, Ielizaveta Gorodetska, Daria Klusa, Qihui Shi, Tiago C. Alves, Klaus Pantel and Anna Dubrovska

Seminars in Cancer Biology, 2022, 82, 94
DOI: 10.1016/j.semcancer.2020.12.002

Reproduction Stage Differentiates the Time-Course Regulation of Metabolites in Daphnia magna

Tae-Yong Jeong and Myrna J. Simpson

Environ. Sci. Technol., 2019, 53, 12764
DOI: 10.1021/acs.est.9b03762

LC-ESI-QOrbitrap™ MS/MS within pesticide residue analysis in fruits and vegetables

Łukasz Rajski, María Jesús Martínez-Bueno, Carmen Ferrer and Amadeo R. Fernández-Alba

TrAC Trends in Analytical Chemistry, 2019, 118, 587
DOI: 10.1016/j.trac.2019.06.032

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses

Na Zhou, Hailong Qi, Junjun Liu, Guangze Zhang, Jianping Liu, Ning Liu, Minglu Zhu, Xuyang Zhao, Chang Song, Zhe Zhou, Jingjing Gong, Ridong Li, Xinyu Bai, Yan Jin, Yongfeng Song and Yuxin Yin

Cell Metabolism, 2022, 34, 1023
DOI: 10.1016/j.cmet.2022.05.005

Association of Metabolomic Biomarkers with Sleeve Gastrectomy Weight Loss Outcomes

Wendy M. Miller, Kathryn M. Ziegler, Ali Yilmaz, Nazia Saiyed, Ilyas Ustun, Sumeyya Akyol, Jay Idler, Matthew D. Sims, Michael E. Maddens and Stewart F. Graham

Metabolites, 2023, 13, 506
DOI: 10.3390/metabo13040506

Plasma Metabolomics and Lipidomics Reveal Perturbed Metabolites in Different Disease Stages of Chronic Obstructive Pulmonary Disease

Juntuo Zhou, Qiuyu Li, Chengyang Liu, Ruifang Pang and Yuxin Yin

COPD, 2020, Volume 15, 553
DOI: 10.2147/COPD.S229505

Plasma Sulfur Amino Acids and Risk of Cerebrovascular Diseases

Kathrine J. Vinknes, Helga Refsum, Cheryl Turner, Kay-Tee Khaw, Nicholas J. Wareham, Nita G. Forouhi and Fumiaki Imamura

Stroke, 2021, 52, 172
DOI: 10.1161/STROKEAHA.120.029177

Novel high-coverage targeted metabolomics method (SWATHtoMRM) for exploring follicular fluid metabolome alterations in women with recurrent spontaneous abortion undergoing in vitro fertilization

Jingyan Song, Xiaoming Wang, Ying Guo, Yi Yang, Kaiyue Xu, Tianqi Wang, Yuanhong Sa, Lihua Yuan, Huaying Jiang, Jiayin Guo and Zhengao Sun

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-47370-7

Drug-resistant Escherichia coli metabolomics via pseudo-targeted SWATH/IDA-MRM: Bridging high coverage and precision

Xi Jia, Liang Zhao, Saiwa Liu, Jingjing Du, Zhinan Wang, Lirui Ge, Jian Xu, Kexin Cui, Yu Ga, Xiaowei Li, Jianzhong Shen and Xi Xia

Journal of Advanced Research, 2025
DOI: 10.1016/j.jare.2025.07.051

Long-chain acylcarnitine deficiency promotes hepatocarcinogenesis

Kaifeng Wang, Zhixian Lan, Heqi Zhou, Rong Fan, Huiyi Chen, Hongyan Liang, Qiuhong You, Xieer Liang, Ge Zeng, Rui Deng, Yu Lan, Sheng Shen, Peng Chen, Jinlin Hou, Pengcheng Bu and Jian Sun

Acta Pharmaceutica Sinica B, 2025, 15, 1383
DOI: 10.1016/j.apsb.2025.01.017

The Use of Metabolomic Tool in Assessing Environmental Exposure

Michele Polyana Rocha Mendes, Leiliane Coelho Andre and Sasho Stoleski

IJOE, 2021, 1, 10
DOI: 10.14302/issn.2690-0904.ijoe-21-3966

Plasma lipidomics in subjects with combat posttraumatic stress disorder

Marcela Konjevod, Jorge Sáiz, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Lucija Tudor, Suzana Uzun, Oliver Kozumplik, Coral Barbas, Neven Zarkovic, Nela Pivac and Dubravka Svob Strac

Free Radical Biology and Medicine, 2022, 189, 169
DOI: 10.1016/j.freeradbiomed.2022.07.012

Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans

Mariola Olkowicz, Izabela Czyzynska-Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki and Ryszard T. Smolenski

J Transl Med, 2021, 19
DOI: 10.1186/s12967-020-02663-8

Robust quantitation of gangliosides and sulfatides in human brain using UHPLC-MRM-MS: Method development and application in Alzheimer's disease

Wai-Him Chan, Lee-Fong Yau, Xiong-Yu Meng, Ka-Man Chan, Zhi-Hong Jiang and Jing-Rong Wang

Talanta, 2023, 256, 124264
DOI: 10.1016/j.talanta.2023.124264

Integrated metabolomics and proteomics analysis of plasma lipid metabolism in Parkinson’s disease

Paulina Gątarek and Joanna Kałużna-Czaplińska

Expert Review of Proteomics, 2024, 21, 13
DOI: 10.1080/14789450.2024.2315193

Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Žiga Tkalec, Jean-Philippe Antignac, Nicole Bandow, Frederic M. Béen, Lidia Belova, Jos Bessems, Bruno Le Bizec, Werner Brack, German Cano-Sancho, Jade Chaker, Adrian Covaci, Nicolas Creusot, Arthur David, Laurent Debrauwer, Gaud Dervilly, Radu Corneliu Duca, Valérie Fessard, Joan O. Grimalt, Thierry Guerin, Baninia Habchi, Helge Hecht, Juliane Hollender, Emilien L. Jamin, Jana Klánová, Tina Kosjek, Martin Krauss, Marja Lamoree, Gwenaelle Lavison-Bompard, Jeroen Meijer, Ruth Moeller, Hans Mol, Sophie Mompelat, An Van Nieuwenhuyse, Herbert Oberacher, Julien Parinet, Christof Van Poucke, Robert Roškar, Anne Togola, Jurij Trontelj and Elliott J. Price

Environment International, 2024, 186, 108585
DOI: 10.1016/j.envint.2024.108585

Applications of chromatographic methods in metabolomics: A review

Susan T. Ovbude, Sadia Sharmeen, Isaac Kyei, Harshana Olupathage, Jacob Jones, Richard J. Bell, Robert Powers and David S. Hage

Journal of Chromatography B, 2024, 1239, 124124
DOI: 10.1016/j.jchromb.2024.124124

Recent development on liquid chromatography-mass spectrometry analysis of oxidized lipids

Luxiao Li, Shanshan Zhong, Xia Shen, Qiujing Li, Wenxin Xu, Yongzhen Tao and Huiyong Yin

Free Radical Biology and Medicine, 2019, 144, 16
DOI: 10.1016/j.freeradbiomed.2019.06.006

Targeted N-Glycan Analysis with Parallel Reaction Monitoring Using a Quadrupole-Orbitrap Hybrid Mass Spectrometer

Byeong Gwan Cho, Cristian D. Gutierrez Reyes, Mona Goli, Sakshi Gautam, Alireza Banazadeh and Yehia Mechref

Anal. Chem., 2022, 94, 15215
DOI: 10.1021/acs.analchem.2c01975

Application of Metabolomics to Epidemiological Studies of Atherosclerosis and Cardiovascular Disease

Miho Iida, Sei Harada and Toru Takebayashi

JAT, 2019, 26, 747
DOI: 10.5551/jat.RV17036

A preliminary study of rapid-fire high-throughput metabolite analysis using nano-flow injection/Q-TOFMS

Kentaro Taki, Saki Noda, Yumi Hayashi, Hitoshi Tsuchihashi, Akira Ishii and Kei Zaitsu

Anal Bioanal Chem, 2020, 412, 4127
DOI: 10.1007/s00216-020-02645-1

Automated Composition Assessment of Natural Extracts: Untargeted Mass Spectrometry-Based Metabolite Profiling Integrating Semiquantitative Detection

Adriano Rutz and Jean-Luc Wolfender

J. Agric. Food Chem., 2023, 71, 18010
DOI: 10.1021/acs.jafc.3c03099

Challenges in LC–MS-based metabolomics for Alzheimer’s disease early detection: targeted approaches versus untargeted approaches

Pierluigi Reveglia, Carmela Paolillo, Gabriella Ferretti, Armando De Carlo, Antonella Angiolillo, Rosarita Nasso, Mafalda Caputo, Carmela Matrone, Alfonso Di Costanzo and Gaetano Corso

Metabolomics, 2021, 17
DOI: 10.1007/s11306-021-01828-w

FUNCTIONAL METABOLOMICS DECIPHER BIOCHEMICAL FUNCTIONS AND ASSOCIATED MECHANISMS UNDERLIE SMALL‐MOLECULE METABOLISM

Longlong Hu, Jingjing Liu, Wenhua Zhang, Tianyu Wang, Ning Zhang, Yie Hou Lee and Haitao Lu

Mass Spectrometry Reviews, 2020, 39, 417
DOI: 10.1002/mas.21611

Unravelling the brain metabolome: A review of liquid chromatography - mass spectrometry strategies for extracellular brain metabolomics

Liam Nestor, Dimitri De Bundel, Yvan Vander Heyden, Ilse Smolders and Ann Van Eeckhaut

Journal of Chromatography A, 2023, 1712, 464479
DOI: 10.1016/j.chroma.2023.464479

The influence of culture media upon observed cell secretome metabolite profiles: The balance between cell viability and data interpretability

Evangelia Daskalaki, Nicolas J. Pillon, Anna Krook, Craig E. Wheelock and Antonio Checa

Analytica Chimica Acta, 2018, 1037, 338
DOI: 10.1016/j.aca.2018.04.034

Single cell metabolomics using mass spectrometry: Techniques and data analysis

Renmeng Liu and Zhibo Yang

Analytica Chimica Acta, 2021, 1143, 124
DOI: 10.1016/j.aca.2020.11.020

Early Metabolomic Markers of Acute Low-Dose Exposure to Uranium in Rats

Stéphane Grison, Baninia Habchi, Céline Gloaguen, Dimitri Kereselidze, Christelle Elie, Jean-Charles Martin and Maâmar Souidi

Metabolites, 2022, 12, 421
DOI: 10.3390/metabo12050421

Metabolomics identifies serum and exosomes metabolite markers of pancreatic cancer

Lianyuan Tao, Juntuo Zhou, Chunhui Yuan, Lingfu Zhang, Deyu Li, Dandan Si, Dianrong Xiu and Lijun Zhong

Metabolomics, 2019, 15
DOI: 10.1007/s11306-019-1550-1

Quantitative Analytical and Computational Workflow for Large-Scale Targeted Plasma Metabolomics

Antonia Fecke, Nay Min Min Thaw Saw, Dipali Kale, Siva Swapna Kasarla, Albert Sickmann and Prasad Phapale

Metabolites, 2023, 13, 844
DOI: 10.3390/metabo13070844

Metabolomics-based engineering for biofuel and bio-based chemical production in microalgae and cyanobacteria: A review

Yuichi Kato, Kosuke Inabe, Ryota Hidese, Akihiko Kondo and Tomohisa Hasunuma

Bioresource Technology, 2022, 344, 126196
DOI: 10.1016/j.biortech.2021.126196

Panomics for Precision Medicine

Charanjit Sandhu, Alia Qureshi and Andrew Emili

Trends in Molecular Medicine, 2018, 24, 85
DOI: 10.1016/j.molmed.2017.11.001

GC–MS‐based metabolomics elucidates the impact of cereal‐based microbial starters on the metabolite profile of mahewu prepared from yellow maize

Grace Abosede Daji, Ezekiel Green, Gabriel Bidemi Akanni and Oluwafemi Ayodeji Adebo

Int J of Food Sci Tech, 2024, 59, 4268
DOI: 10.1111/ijfs.16667

Metabolomic changes in vertebrate host during malaria disease progression

Soumita Ghosh, Sulabha Pathak, Haripalsingh M. Sonawat, Shobhona Sharma and Arjun Sengupta

Cytokine, 2018, 112, 32
DOI: 10.1016/j.cyto.2018.07.022

MRMkit: Automated Data Processing for Large-Scale Targeted Metabolomics Analysis

Guoshou Teo, Wee Siong Chew, Bo J. Burla, Deron Herr, E Shyong Tai, Markus R. Wenk, Federico Torta and Hyungwon Choi

Anal. Chem., 2020, 92, 13677
DOI: 10.1021/acs.analchem.0c03060

Ultra-High-Performance Liquid Chromatography–Orbitrap-MS-Based Untargeted Lipidomics Reveal Lipid Characteristics of a Clinical Strain of Mycoplasma bovis from Holstein Cow

Fei Yang, Mengmeng Yang, Fan Liu, Yanrong Qi, Yanan Guo and Shenghu He

Veterinary Sciences, 2024, 11, 577
DOI: 10.3390/vetsci11110577

Cellular metabolomics: From sample preparation to high-throughput data analysis

Yang Zhao, Estatira Sepehr, Cory Vaught, Jeffrey Yourick and Robert L. Sprando

Journal of Agriculture and Food Research, 2024, 15, 100935
DOI: 10.1016/j.jafr.2023.100935

New advances in analytical methods for mass spectrometry-based large-scale metabolomics study

Xinyu Liu, Lina Zhou, Xianzhe Shi and Guowang Xu

TrAC Trends in Analytical Chemistry, 2019, 121, 115665
DOI: 10.1016/j.trac.2019.115665

Use of Hybrid Capillary Tube Apparatus on 400 MHz NMR for Quantitation of Crucial Low-Quantity Metabolites Using aSICCO Signal

Ranjeet Tiwari, Deepak Ahire, Hemantha Kumar, Sarmistha Sinha, Siddheshwar Kisan Chauthe, Murali Subramanian, Ramaswamy Iyer, Ramakanth Sarabu and Lakshmikant Bajpai

Drug Metabolism and Disposition, 2017, 45, 1215
DOI: 10.1124/dmd.117.077073

Evaluation of Metabolism of a Defined Pesticide Mixture through Multiple In Vitro Liver Models

Alan Valdiviezo, Yuki Kato, Erin S. Baker, Weihsueh A. Chiu and Ivan Rusyn

Toxics, 2022, 10, 566
DOI: 10.3390/toxics10100566

Modified mycotoxins in foodstuffs, animal feed, and herbal medicine: A systematic review on global occurrence, transformation mechanism and analysis methods

Qian Lu, Jia-An Qin, Yan-Wei Fu, Jiao-Yang Luo, Jiang-Hai Lu, Antonio F. Logrieco and Mei-Hua Yang

TrAC Trends in Analytical Chemistry, 2020, 133, 116088
DOI: 10.1016/j.trac.2020.116088

Unraveling mosquito metabolism with mass spectrometry-based metabolomics

Thomas D. Horvath, Shai Dagan and Patricia Y. Scaraffia

Trends in Parasitology, 2021, 37, 747
DOI: 10.1016/j.pt.2021.03.010

The metabolomic profile of endometrial receptivity in recurrent miscarriage

Laurentiu CRACIUNAS, Justin CHU, Oonagh PICKERING, Lamiya MOHIYIDDEEN and Arri COOMARASAMY

Minerva Obstet Gynecol, 2023, 75
DOI: 10.23736/S2724-606X.22.05151-X

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics

Ho-Joon Lee, Daniel M. Kremer, Peter Sajjakulnukit, Li Zhang and Costas A. Lyssiotis

Metabolomics, 2019, 15
DOI: 10.1007/s11306-019-1564-8

Optimization of the Data Treatment Steps of a Non-targeted LC-MS-Based Workflow for the Identification of Trace Chemical Residues in Honey

Annie von Eyken and Stéphane Bayen

J. Am. Soc. Mass Spectrom., 2019, 30, 765
DOI: 10.1007/s13361-019-02157-y

Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS

M.F. Moedas, A.A.A. Adam, M.A. Farelo, L. IJlst, R.A.F.M. Chamuleau, R. Hoekstra, R.J.A. Wanders and M.F.B. Silva

Analytical Biochemistry, 2017, 535, 47
DOI: 10.1016/j.ab.2017.07.025

Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities

Tzu-Jen Kao, Chien-Liang Lin, Wen-Bin Yang, Hao-Yi Li and Tsung-I Hsu

Lipids Health Dis, 2023, 22
DOI: 10.1186/s12944-023-01881-5

Mass spectrometry based proteomics and metabolomics in personalized oncology

Tomasz Kowalczyk, Michal Ciborowski, Joanna Kisluk, Adam Kretowski and Coral Barbas

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020, 1866, 165690
DOI: 10.1016/j.bbadis.2020.165690

Towards predicting the environmental metabolome from metagenomics with a mechanistic model

Daniel R. Garza, Marcel C. van Verk, Martijn A. Huynen and Bas E. Dutilh

Nat Microbiol, 2018, 3, 456
DOI: 10.1038/s41564-018-0124-8

Lipidomics in Understanding Pathophysiology and Pharmacologic Effects in Inflammatory Diseases: Considerations for Drug Development

Kabir Ahluwalia, Brandon Ebright, Kingsley Chow, Priyal Dave, Andrew Mead, Roy Poblete, Stan G. Louie and Isaac Asante

Metabolites, 2022, 12, 333
DOI: 10.3390/metabo12040333

Psychological distress and metabolomic markers: A systematic review of posttraumatic stress disorder, anxiety, and subclinical distress

Yiwen Zhu, Shaili C. Jha, Katherine H. Shutta, Tianyi Huang, Raji Balasubramanian, Clary B. Clish, Susan E. Hankinson and Laura D. Kubzansky

Neuroscience & Biobehavioral Reviews, 2022, 143, 104954
DOI: 10.1016/j.neubiorev.2022.104954

Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies

Marynka M. Ulaszewska, Christoph H. Weinert, Alessia Trimigno, Reto Portmann, Cristina Andres Lacueva, René Badertscher, Lorraine Brennan, Carl Brunius, Achim Bub, Francesco Capozzi, Marta Cialiè Rosso, Chiara E. Cordero, Hannelore Daniel, Stéphanie Durand, Bjoern Egert, Paola G. Ferrario, Edith J.M. Feskens, Pietro Franceschi, Mar Garcia‐Aloy, Franck Giacomoni, Pieter Giesbertz, Raúl González‐Domínguez, Kati Hanhineva, Lieselot Y. Hemeryck, Joachim Kopka, Sabine E. Kulling, Rafael Llorach, Claudine Manach, Fulvio Mattivi, Carole Migné, Linda H. Münger, Beate Ott, Gianfranco Picone, Grégory Pimentel, Estelle Pujos‐Guillot, Samantha Riccadonna, Manuela J. Rist, Caroline Rombouts, Josep Rubert, Thomas Skurk, Pedapati S. C. Sri Harsha, Lieven Van Meulebroek, Lynn Vanhaecke, Rosa Vázquez‐Fresno, David Wishart and Guy Vergères

Molecular Nutrition Food Res, 2019, 63
DOI: 10.1002/mnfr.201800384

A preliminary study procedure for detection of polyamines in plasma samples as a potential diagnostic tool in prostate cancer

Donatella Coradduzza, Emanuela Azara, Serenella Medici, Caterina Arru, Tatiana Solinas, Massimo Madonia, Angelo Zinellu and Ciriaco Carru

Journal of Chromatography B, 2021, 1162, 122468
DOI: 10.1016/j.jchromb.2020.122468

Metabolomics: current application and prospects in crop production

Temitayo Tosin Alawiye and Olubukola Oluranti Babalola

Biologia, 2021, 76, 227
DOI: 10.2478/s11756-020-00574-z

Phytotoxicity of microplastics to the floating plant Spirodela polyrhiza (L.): Plant functional traits and metabolomics

Yaqi Wang, Junhong Bai, Lixiang Wen, Wei Wang, Ling Zhang, Zhe Liu and Haizhu Liu

Environmental Pollution, 2023, 322, 121199
DOI: 10.1016/j.envpol.2023.121199

Stability of Metabolomic Content during Sample Preparation: Blood and Brain Tissues

Maxim V. Fomenko, Lyudmila V. Yanshole and Yuri P. Tsentalovich

Metabolites, 2022, 12, 811
DOI: 10.3390/metabo12090811

Accurate Determination of Circulatory Lipids Using a Combination of HILIC-MRM and RPLC-PRM

Kyeong-Seog Kim, Jae-Seung Lee, Seung Seok Han and Joo-Youn Cho

Anal. Chem., 2025, 97, 9713
DOI: 10.1021/acs.analchem.4c06409

Integration of untargeted and targeted mass spectrometry-based metabolomics provides novel insights into the potential toxicity associated to surfynol

Estefania Garcia-Calvo, Andres Machuca, Cristina Nerín, Noelia Rosales-Conrado, Daniela S. Anunciação and Jose L. Luque-Garcia

Food and Chemical Toxicology, 2020, 146, 111849
DOI: 10.1016/j.fct.2020.111849

Analyzing Assay Specificity in Metabolomics Using Unique Ion Signature Simulations

Premy Shanthamoorthy, Adamo Young and Hannes Röst

Anal. Chem., 2021, 93, 11415
DOI: 10.1021/acs.analchem.1c01204

Exploration of metabolomics of Phyllanthus emblica: From ayurveda food to modern prospectives in quality control

Grishm Ruhela, Pooja Dhama, Karuna Shanker, Xianting Ding and Alok Sharma

Food Chemistry Advances, 2023, 3, 100330
DOI: 10.1016/j.focha.2023.100330

An untargeted and pseudotargeted metabolomic combination approach to identify differential markers to distinguish live from dead pork meat by liquid chromatography–mass spectrometry

Mengsi Cao, Qing'an Han, Jianhong Zhang, Ruoxi Zhang, Jiancheng Wang, Wenyuan Gu, Weijun Kang, Kaoqi Lian and Lianfeng Ai

Journal of Chromatography A, 2020, 1610, 460553
DOI: 10.1016/j.chroma.2019.460553

Integration of non-targeted multicomponent profiling, targeted characteristic chromatograms and quantitative to accomplish systematic quality evaluation strategy of Huo-Xiang-Zheng-Qi oral liquid

Xuejuan Li, Mengfan Wu, Hui Ding, Wei Li, Jiaxin Yin, Ruimei Lin, Xinlong Wu, Lifeng Han, Wenzhi Yang, Songtao Bie, Fangyi Li, Xinbo Song, Heshui Yu, Ziliang Dong and Zheng Li

Journal of Pharmaceutical and Biomedical Analysis, 2023, 236, 115715
DOI: 10.1016/j.jpba.2023.115715

High-Resolution QTOF-MRM for Highly Accurate Identification and Quantification of Trace Levels of Triterpenoids in Ganoderma lucidum Mycelium

Khwanta Kaewnarin, Suphitcha Limjiasahapong, Narumol Jariyasopit, Krittima Anekthanakul, Alongkorn Kurilung, Stephen Choong Chee Wong, Yongyut Sirivatanauksorn, Wonnop Visessanguan and Sakda Khoomrung

J. Am. Soc. Mass Spectrom., 2021, 32, 2451
DOI: 10.1021/jasms.1c00175

Development and comparison of parallel reaction monitoring and data-independent acquisition methods for quantitative analysis of hydrophilic compounds in white tea

Dan Wang, Zhihao Yu, Jie Guo, Meiyan Liu, Mengdi Guan, Ying Gu, Siyu Li, Dabing Ren and Lunzhao Yi

Journal of Chromatography A, 2024, 1715, 464601
DOI: 10.1016/j.chroma.2023.464601

Improved quantification of carbonyl sub-metabolome by liquid chromatography mass spectrometry using a fragment controlled multiplexed isotopic tag

Xiaobo Tian and Gérard Hopfgartner

Analytica Chimica Acta, 2024, 1287, 342117
DOI: 10.1016/j.aca.2023.342117

TRACES: A Lightweight Browser for Liquid Chromatography–Multiple Reaction Monitoring–Mass Spectrometry Chromatograms

Yoshihiro Kita, Suzumi M. Tokuoka, Yoshiya Oda and Takao Shimizu

Metabolites, 2022, 12, 354
DOI: 10.3390/metabo12040354

A Widely Metabolomic Analysis Revealed Metabolic Alterations of Epimedium Pubescens Leaves at Different Growth Stages

Zhenxian Qin, Dengqun Liao, Yalan Chen, Chenyang Zhang, Ruipeng An, Qing Zeng and Xian’en Li

Molecules, 2019, 25, 137
DOI: 10.3390/molecules25010137

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Ryeong Ha Kwon, Hyemin Na, Ju Hyung Kim, So Ah Kim, Se Yeon Kim, Hyun-Ah Jung, Sang Hoon Lee, Chi-Do Wee, Kwang-Sik Lee and Heon-Woong Kim

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-77574-5

Plants Metabolome Study: Emerging Tools and Techniques

Manish Patel, Sonika Pandey, Manoj Kumar, Md Haque, Sikander Pal and Narendra Yadav

Plants, 2021, 10, 2409
DOI: 10.3390/plants10112409

Metabolomics in antimicrobial drug discovery

Rustam Aminov

Expert Opinion on Drug Discovery, 2022, 17, 1047
DOI: 10.1080/17460441.2022.2113774

Gastric cancer detection by non‐blood‐based liquid biopsies: A systematic review looking into the last decade of research

Catarina Lopes, Jéssica Chaves, Raquel Ortigão, Mário Dinis‐Ribeiro and Carina Pereira

UEG Journal, 2023, 11, 114
DOI: 10.1002/ueg2.12328

Targeted analysis of seven selected tryptophan-melatonin metabolites: Simultaneous quantification of plasma analytes using fast and sensitive UHPLC–MS/MS

Michal Kaleta, Bhagya S. Kolitha, Ondřej Novák, Farshid Mashayekhy Rad, Jonas Bergquist and S.J. Kumari A. Ubhayasekera

Journal of Chromatography B, 2025, 1256, 124520
DOI: 10.1016/j.jchromb.2025.124520

Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome

Yan Jin, Jinhua Chi, Kaelene LoMonaco, Alexandria Boon and Haiwei Gu

TrAC Trends in Analytical Chemistry, 2023, 166, 117155
DOI: 10.1016/j.trac.2023.117155

Metabolomic-based clinical studies and murine models for acute pancreatitis disease: A review

Yang Peng, Jiwon Hong, Daniel Raftery, Qing Xia and Dan Du

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021, 1867, 166123
DOI: 10.1016/j.bbadis.2021.166123

Omics of antimicrobials and antimicrobial resistance

Vladislav M. Chernov, Olga A. Chernova, Alexey A. Mouzykantov, Leonid L. Lopukhov and Rustam I. Aminov

Expert Opinion on Drug Discovery, 2019, 14, 455
DOI: 10.1080/17460441.2019.1588880

Recent Advances in Understanding of Alzheimer’s Disease Progression Through Mass Spectrometry-Based Metabolomics

Jericha Mill and Lingjun Li

Phenomics, 2022, 2, 1
DOI: 10.1007/s43657-021-00036-9

Serially coupled reversed phase-hydrophilic interaction liquid chromatography–tailored multiple reaction monitoring, a fit-for-purpose tool for large-scale targeted metabolomics of medicinal bile

Qingqing Song, Wenjing Liu, Xiaojia Chen, Jun Li, Peng Li, Fengqing Yang, Yitao Wang, Yuelin Song and Pengfei Tu

Analytica Chimica Acta, 2018, 1037, 119
DOI: 10.1016/j.aca.2017.11.072

From flesh to bones: Multi‐omics approaches in forensic science

Noemi Procopio and Andrea Bonicelli

Proteomics, 2024, 24
DOI: 10.1002/pmic.202200335

Integration of targeted metabolome and transcript profiling of Pseudomonas syringae-triggered changes in defence-related phytochemicals in oat plants

Chanel J. Pretorius and Ian A. Dubery

Planta, 2024, 260
DOI: 10.1007/s00425-024-04435-w

Integration of Non-Targeted Multicomponent Profiling, Targeted Characteristic Chromatograms and Quantitative to Accomplish Systematic Quality Evaluation Strategy of Huo-Xiang-Zheng-Qi Oral Liquid

Heshui Yu, Mengfan Wu, Hui Ding, Wei Li, Jiaxin Yin, Lin Ruimei, Xinlong Wu, Lifeng Han, Wenzhi Yang, Songtao Bie, Fangyi Li, Xinbo Song, Ziliang Dong and Zheng Li

SSRN Journal, 2022
DOI: 10.2139/ssrn.4127598

Can Metabolomic Approaches Become a Tool for Improving Early Plant Disease Detection and Diagnosis with Modern Remote Sensing Methods? A Review

Anton Terentev and Viktor Dolzhenko

Sensors, 2023, 23, 5366
DOI: 10.3390/s23125366

Combined targeted/untargeted analytical and chemometric approaches in the characterization of Daphnia magna metabolomic changes under bisphenol A exposure

Elba Garreta-Lara, Cristian Gómez-Canela, Bruno Campos, Carlos Barata, Romà Tauler and Silvia Lacorte

Microchemical Journal, 2021, 165, 106150
DOI: 10.1016/j.microc.2021.106150

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long‐term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

Sabine U. Vorrink, Shahid Ullah, Staffan Schmidt, Jatin Nandania, Vidya Velagapudi, Olof Beck, Magnus Ingelman‐Sundberg and Volker M. Lauschke

FASEB j., 2017, 31, 2696
DOI: 10.1096/fj.201601375R

Machine Learning-Driven Insights in Cancer Metabolomics: From Subtyping to Biomarker Discovery and Prognostic Modeling

Amr Elguoshy, Hend Zedan and Suguru Saito

Metabolites, 2025, 15, 514
DOI: 10.3390/metabo15080514

Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease

Yaping Shao and Weidong Le

Mol Neurodegeneration, 2019, 14
DOI: 10.1186/s13024-018-0304-2

Translational Metabolomics: Current Challenges and Future Opportunities

Farhana R. Pinu, Seyed Ali Goldansaz and Jacob Jaine

Metabolites, 2019, 9, 108
DOI: 10.3390/metabo9060108

Metabolomics approach for phenolic compounds profiling of soursop (Annona muricata L.) fruit during postharvest storage

Verónica Alhelí Ochoa-Jiménez, Guillermo Berumen-Varela, Iza Fernanda Pérez-Ramírez, Rosendo Balois-Morales, Alejandro Rubio-Melgarejo and Pedro Ulises Bautista-Rosales

Metabolomics, 2024, 20
DOI: 10.1007/s11306-024-02093-3

Metabolomic Study of Urine from Workers Exposed to Low Concentrations of Benzene by UHPLC-ESI-QToF-MS Reveals Potential Biomarkers Associated with Oxidative Stress and Genotoxicity

Michele P. R. Mendes, Maria José N. Paiva, Isabele C. Costa-Amaral, Leandro V. B. Carvalho, Victor O. Figueiredo, Eline S. Gonçalves, Ariane L. Larentis and Leiliane C. André

Metabolites, 2022, 12, 978
DOI: 10.3390/metabo12100978

Application of Quantitative Proton Nuclear Magnetic Resonance Spectroscopy for Determination of the Content of Geniposide in Gardeniae fructus

Jian-Wei Dong, Ya-Li Li, Xue-Jiao Li, Xiao-Xin Xu and Feng-Xian Li

CPA, 2025, 20, 1066
DOI: 10.2174/0115734129352488241105104605

Norm ISWSVR Enhanced Data Repeatability and Accuracy in Large-Scale Targeted Quantification Metabolomics

Jinpeng Bai, Chenxi Li, Mingmin Qian, Xian Ding, Qian Li, Yanhua Chen, Zhaoying Wang and Zeper Abliz

J. Am. Soc. Mass Spectrom., 2025, 36, 1027
DOI: 10.1021/jasms.4c00467

Metaproteomic and Metabolomic Approaches for Characterizing the Gut Microbiome

Danielle L. Peters, Wenju Wang, Xu Zhang, Zhibin Ning, Janice Mayne and Daniel Figeys

Proteomics, 2019, 19
DOI: 10.1002/pmic.201800363

Comparison of chromatographic conditions for the targeted tandem mass spectrometric determination of 354 mammalian metabolites

Dimitrios J. Floros, Kangkang Xu, Franz Berthiller and Heidi Schwartz-Zimmermann

Journal of Chromatography A, 2023, 1697, 463985
DOI: 10.1016/j.chroma.2023.463985

Identification of cerebrospinal fluid metabolites as biomarkers for neurobrucellosis by liquid chromatography-mass spectrometry approach

Hao Yang, Zhenfei Wang, Shujun Shi, Qin Yu, Meiling Liu and Zhelin Zhang

Bioengineered, 2022, 13, 6996
DOI: 10.1080/21655979.2022.2037954

Small molecule biomarker discovery: Proposed workflow for LC-MS-based clinical research projects

S. Rischke, L. Hahnefeld, B. Burla, F. Behrens, R. Gurke and T.J. Garrett

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023, 28, 47
DOI: 10.1016/j.jmsacl.2023.02.003

How to employ metabolomic analysis to research on functions of prebiotics and probiotics in poultry gut health?

Mengjun Wu, Sanling Zuo, Giuseppe Maiorano, Przemysław Kosobucki and Katarzyna Stadnicka

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.1040434

Advanced High-Coverage Targeted Metabolomics Method (SWATHtoMRM) for Exploring the Relationship of Follicular Fluid Components with Age

Jingyan Song, Tianqi Wang, Jiayin Guo, Ying Guo, Xiaoming Wang, Yi Yang, Kaiyue Xu, Yuanhong Sa, Lihua Yuan, Huaying Jiang and Zhengao Sun

CPA, 2020, 16, 291
DOI: 10.2174/1573412915666190218155820

Characterization of chemical constituents and metabolites in vivo and in vitro after oral administration of Wuteng tablets in rats by UHPLC–Q/TOF–MS

Pengyi Chen, Chengguo Pang, Tianen Xu, Peiliang Dong and Hua Han

Biomedical Chromatography, 2023, 37
DOI: 10.1002/bmc.5704

Reproduction stage specific dysregulation of Daphnia magna metabolites as an early indicator of reproductive endocrine disruption

Tae-Yong Jeong and Myrna J. Simpson

Water Research, 2020, 184, 116107
DOI: 10.1016/j.watres.2020.116107

Establishing an untargeted-to-MRM liquid chromatography–mass spectrometry method for discriminating reconstituted milk from ultra-high temperature milk

Dongfei Tan, Xia Zhang, Meicheng Su, Man Jia, Dan Zhu, Biniam Kebede, Huaxing Wu and Gang Chen

Food Chemistry, 2021, 337, 127946
DOI: 10.1016/j.foodchem.2020.127946

Recent advancement in mass based plant metabolomics: techniques, tools, and analytical approaches

Nitish Kumar, Jare Shrikrushna Bharat, Amit Kumar and Vikas Jaitak

Phytochem Rev, 2024
DOI: 10.1007/s11101-024-10028-y

Functional Genomics Approaches to Studying Symbioses between Legumes and Nitrogen-Fixing Rhizobia

Martina Lardi and Gabriella Pessi

High-Throughput, 2018, 7, 15
DOI: 10.3390/ht7020015

An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization

Ju Wang, Wei Zheng, Shuoping Zhang, Keqiang Yan, Miao Jin, Huiling Hu, Zhen Ma, Fei Gong, Guangxiu Lu, Yan Ren, Liang Lin, Ge Lin, Liang Hu and Siqi Liu

BMC Biol, 2021, 19
DOI: 10.1186/s12915-021-01118-w

Applications of liquid chromatography-mass spectrometry based metabolomics in predictive and personalized medicine

Juntuo Zhou and Lijun Zhong

Front. Mol. Biosci., 2022, 9
DOI: 10.3389/fmolb.2022.1049016

Current and future perspectives of functional metabolomics in disease studies–A review

Min Yan and Guowang Xu

Analytica Chimica Acta, 2018, 1037, 41
DOI: 10.1016/j.aca.2018.04.006

Metabolomics markers in Neurology: current knowledge and future perspectives for therapeutic targeting

Roberta Bonomo, Guido Cavaletti and Debra J. Skene

Expert Review of Neurotherapeutics, 2020, 20, 725
DOI: 10.1080/14737175.2020.1782746

Enhanced MS/MS coverage for metabolite identification in LC-MS-based untargeted metabolomics by target-directed data dependent acquisition with time-staggered precursor ion list

Yang Wang, Ruibing Feng, Ruibing Wang, Fengqing Yang, Peng Li and Jian-Bo Wan

Analytica Chimica Acta, 2017, 992, 67
DOI: 10.1016/j.aca.2017.08.044

Exploration advantages of data combination and partition: First chemometric analysis of liquid chromatography–mass spectrometry data in full scan mode with quadruple fragmentor voltages

Xiao-Dong Sun, Hai-Long Wu, Jun-Chen Chen, An-Qi Chen, Yue Chen, Yang-Zi Ouyang, Yu-Jie Ding and Ru-Qin Yu

Analytica Chimica Acta, 2020, 1110, 158
DOI: 10.1016/j.aca.2020.03.018

Simultaneous determination of alkaloids dicentrine and sinomenine in Stephania epigeae by 1H NMR spectroscopy

Jian-Wei Dong, Xue-Jiao Li, Le Cai, Jun-You Shi, Yu-Feng Li, Cui Yang and Zhen-Jie Li

Journal of Pharmaceutical and Biomedical Analysis, 2018, 160, 330
DOI: 10.1016/j.jpba.2018.08.007

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

Zhi Zhang, Yuyao Zhang, Shiwen Song, Lei Yin, Dong Sun and Jingkai Gu

J of Separation Science, 2020, 43, 1978
DOI: 10.1002/jssc.201901340

Application of Chromatographic and Electrophoretic Techniques to Metabolomic Studies

L. A. Kartsova and S. A. Solov’eva

J Anal Chem, 2019, 74, 307
DOI: 10.1134/S1061934819040051

Identification of Metabolite Interference Is Necessary for Accurate LC-MS Targeted Metabolomics Analysis

Zhikun Jia, Qiongju Qiu, Ruiping He, Tianyu Zhou and Li Chen

Anal. Chem., 2023, 95, 7985
DOI: 10.1021/acs.analchem.3c00804

Uric acid metabolism promotes apoptosis against Bombyx mori nucleopolyhedrovirus in silkworm, Bombyx mori

Zhi‐hao Su, Jun‐li Lv, Qi Ou, Zi‐qin Zhao, Kai‐yi Zheng, Xiao‐ying Zhang, Wen‐qing Lai, Xue‐yang Wang, Ming‐jie Deng and Mu‐wang Li

Insect Molecular Biology, 2023, 32, 558
DOI: 10.1111/imb.12850

Main strategies, analytical trends and challenges in LC-MS and ambient mass spectrometry–based metabolomics

Justyna Aszyk, Hubert Byliński, Jacek Namieśnik and Agata Kot-Wasik

TrAC Trends in Analytical Chemistry, 2018, 108, 278
DOI: 10.1016/j.trac.2018.09.010

Strategies for Using Postcolumn Infusion of Standards to Correct for Matrix Effect in LC-MS-Based Quantitative Metabolomics

Anne-Charlotte Dubbelman, Bo van Wieringen, Lesley Roman Arias, Michael van Vliet, Roel Vermeulen, Amy C. Harms and Thomas Hankemeier

J. Am. Soc. Mass Spectrom., 2024, 35, 3286
DOI: 10.1021/jasms.4c00408

Metabolomics in Hyperuricemia and Gout

Rui Li, Ningning Liang, Yongzhen Tao and Huiyong Yin

GUCDD, 2023, 1, 49
DOI: 10.3390/gucdd1010006

A high-resolution HPLC-QqTOF platform using parallel reaction monitoring for in-depth lipid discovery and rapid profiling

Dingyi Yu, Thusitha W.T. Rupasinghe, Berin A. Boughton, Siria H.A. Natera, Camilla B. Hill, Pablo Tarazona, Ivo Feussner and Ute Roessner

Analytica Chimica Acta, 2018, 1026, 87
DOI: 10.1016/j.aca.2018.03.062

Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry

Hiroaki Takeda, Yoshihiro Izumi, Masatomo Takahashi, Thanai Paxton, Shohei Tamura, Tomonari Koike, Ying Yu, Noriko Kato, Katsutoshi Nagase, Masashi Shiomi and Takeshi Bamba

Journal of Lipid Research, 2018, 59, 1283
DOI: 10.1194/jlr.D083014

Chemical Isotope Labeling Exposome (CIL-EXPOSOME): One High-Throughput Platform for Human Urinary Global Exposome Characterization

Shenglan Jia, Tengfei Xu, Tao Huan, Maria Chong, Min Liu, Wenjuan Fang and Mingliang Fang

Environ. Sci. Technol., 2019, 53, 5445
DOI: 10.1021/acs.est.9b00285

Metabolic Fingerprinting of Fabry Disease: Diagnostic and Prognostic Aspects

Maria Teresa Rocchetti, Federica Spadaccino, Valeria Catalano, Gianluigi Zaza, Giovanni Stallone, Daniela Fiocco, Giuseppe Stefano Netti and Elena Ranieri

Metabolites, 2022, 12, 703
DOI: 10.3390/metabo12080703

Targeted Metabolic Profiling of Post-Mortem Brain from Infants Who Died from Sudden Infant Death Syndrome

Stewart F. Graham, Onur Turkoglu, Praveen Kumar, Ali Yilmaz, Trent C. Bjorndahl, BeomSoo Han, Rupasri Mandal, David S. Wishart and Ray O. Bahado-Singh

J. Proteome Res., 2017, 16, 2587
DOI: 10.1021/acs.jproteome.7b00157

Plasma metabolomics and lipidomics reveal potential novel biomarkers in early gastric cancer: An explorative study

Feng Wang, Ruifang Pang, Xudong Zhao, Bin Zhou, Yuan Tian, Yongchen Ma and Long Rong

Int J Biol Markers, 2024, 39, 226
DOI: 10.1177/03936155241258780

Perspective: An Extension of the STROBE Statement for Observational Studies in Nutritional Epidemiology (STROBE-nut): Explanation and Elaboration

Agneta Hörnell, Christina Berg, Elisabet Forsum, Christel Larsson, Emily Sonestedt, Agneta Åkesson, Carl Lachat, Dana Hawwash, Patrick Kolsteren, Graham Byrnes, Willem De Keyzer, John Van Camp, Janet E Cade, Darren C Greenwood, Nadia Slimani, Myriam Cevallos, Matthias Egger, Inge Huybrechts and Elisabet Wirfält

Advances in Nutrition, 2017, 8, 652
DOI: 10.3945/an.117.015941

An ultra-robust fingerprinting method for quality assessment of traditional Chinese medicine using multiple reaction monitoring mass spectrometry

Zhenhao Li, Xiaohui Zhang, Jie Liao, Xiaohui Fan and Yiyu Cheng

Journal of Pharmaceutical Analysis, 2021, 11, 88
DOI: 10.1016/j.jpha.2020.01.003

Concepts and Software Package for Efficient Quality Control in Targeted Metabolomics Studies: MeTaQuaC

Mathias Kuhring, Alina Eisenberger, Vanessa Schmidt, Nicolle Kränkel, David M. Leistner, Jennifer Kirwan and Dieter Beule

Anal. Chem., 2020, 92, 10241
DOI: 10.1021/acs.analchem.0c00136

Staring into the void: demystifying microbial metabolomics

Cynthia M Grim, Gordon T Luu and Laura M Sanchez

FEMS Microbiology Letters, 2019, 366
DOI: 10.1093/femsle/fnz135

Profiling Analysis of Tryptophan Metabolites in the Urine of Patients with Parkinson’s Disease Using LC–MS/MS

So Hyeon Chung, Dallah Yoo, Tae-Beom Ahn, Wonwoong Lee and Jongki Hong

Pharmaceuticals, 2023, 16, 1495
DOI: 10.3390/ph16101495

Exploration of variations in proteome and metabolome for predictive diagnostics and personalized treatment algorithms: Innovative approach and examples for potential clinical application

Xianquan Zhan, Ying Long and Miaolong Lu

Journal of Proteomics, 2018, 188, 30
DOI: 10.1016/j.jprot.2017.08.020

Targeted metabolomics revealed key compounds during the pile fermentation process of Liupao tea

Ya Li, Hailin Wu, Jianfeng Liang, Yaobing Guo and Yiru Huang

Eur Food Res Technol, 2025
DOI: 10.1007/s00217-025-04853-4

Simultaneous quantification of serum monounsaturated and polyunsaturated phosphatidylcholines as potential biomarkers for diagnosing non-small cell lung cancer

Yingrong Chen, Zhihong Ma, Jing Zhong, Liqin Li, Lishan Min, Limin Xu, Hongwei Li, Jianbin Zhang, Wei Wu and Licheng Dai

Sci Rep, 2018, 8
DOI: 10.1038/s41598-018-25552-z

Development of simultaneous targeted metabolite quantification and untargeted metabolomics strategy using dual-column liquid chromatography coupled with tandem mass spectrometry

Yang Gao, Yanhua Chen, Xiaofei Yue, Jiuming He, Ruiping Zhang, Jing Xu, Zhi Zhou, Zhonghua Wang, Rui Zhang and Zeper Abliz

Analytica Chimica Acta, 2018, 1037, 369
DOI: 10.1016/j.aca.2018.08.042

Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics

Daisuke Saigusa, Naomi Matsukawa, Eiji Hishinuma and Seizo Koshiba

Drug Metabolism and Pharmacokinetics, 2021, 37, 100373
DOI: 10.1016/j.dmpk.2020.11.008

Relying on biomarkers for intake assessment in nutritio

Lars Ove Dragsted

The American Journal of Clinical Nutrition, 2017, 105, 8
DOI: 10.3945/ajcn.116.148320

Advanced liquid chromatography-mass spectrometry enables merging widely targeted metabolomics and proteomics

Wenjing Liu, Qingqing Song, Yan Cao, Yanan Zhao, Huixia Huo, Yitao Wang, Yuelin Song, Jun Li and Pengfei Tu

Analytica Chimica Acta, 2019, 1069, 89
DOI: 10.1016/j.aca.2019.04.013

Post-Acquisition Data Mining Techniques for LC–MS/MS-Acquired Data in Drug Metabolite Identification

Pooja Sukhdev Dhurjad, Vamsi Krishna Marothu and Rajeshwari Rathod

Bioanalysis, 2017, 9, 1265
DOI: 10.4155/bio-2017-0046

Discrimination and quantification of homologous keratins from goat and sheep with dual protease digestion and PRM assays

Chen Miao, Yunfei Yang, Shanshan Li, Yufeng Guo, Wenqing Shui and Qichen Cao

Journal of Proteomics, 2018, 186, 38
DOI: 10.1016/j.jprot.2018.07.010

PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid metabolism in platinum-resistant gastric cancer

Menglin Chen, Cancan Zhang, Huaizhi Li, Shanshan Zheng, Yaqi Li, Mengyun Yuan, Yuxuan Chen, Jian Wu and Qingmin Sun

J Transl Med, 2024, 22
DOI: 10.1186/s12967-024-05055-4

Metabolomics biomarkers and related pathways in endometrial cancer: A systematic review and meta‐analysis

Xingxu Yan, Shan Zhao, Junjie He, Guijiang Sun, Fang Wang, Haoran Ding, Wenqing Zhang, Wenxiu Qian, Xiaomeng Li, Yuyan Wang and Yubo Li

J Cellular Molecular Medi, 2024, 28
DOI: 10.1111/jcmm.18401

Large-scale targeted metabolomics method for metabolite profiling of human samples

Guodong Cao, Zhengbo Song, Yanjun Hong, Zhiyi Yang, Yuanyuan Song, Zhongjian Chen, Zhaobin Chen and Zongwei Cai

Analytica Chimica Acta, 2020, 1125, 144
DOI: 10.1016/j.aca.2020.05.053

Quantitative multiple fragment monitoring with enhanced in-source fragmentation/annotation mass spectrometry

Samuel Bernardo-Bermejo, Jingchuan Xue, Linh Hoang, Elizabeth Billings, Bill Webb, M. Willy Honders, Sanne Venneker, Bram Heijs, María Castro-Puyana, María Luisa Marina, Erik B. van den Akker, Marieke Griffioen, Gary Siuzdak, Martin Giera and Elena Sánchez-López

Nat Protoc, 2023, 18, 1296
DOI: 10.1038/s41596-023-00803-0

Comprehensive metabolomic and proteomic analyses reveal candidate biomarkers and related metabolic networks in atrial fibrillation

Juntuo Zhou, Lijie Sun, Liwen Chen, Shuwang Liu, Lijun Zhong and Ming Cui

Metabolomics, 2019, 15
DOI: 10.1007/s11306-019-1557-7

Application of metabolomics in quality control of traditional Chinese medicines: a review

Peiran Ji, Xinquan Yang and Xiangsheng Zhao

Front. Plant Sci., 2024, 15
DOI: 10.3389/fpls.2024.1463666

Investigating metabolic dysregulation in serum of triple transgenic Alzheimer’s disease male mice: implications for pathogenesis and potential biomarkers

Hongbin Zhuang, Xueshan Cao, Xiaoxiao Tang, Yongdong Zou, Hongbo Yang, Zhiyuan Liang, Xi Yan, Xiaolu Chen, Xingui Feng and Liming Shen

Amino Acids, 2024, 56
DOI: 10.1007/s00726-023-03375-1

Profiling of Steroid Metabolic Pathways in Human Plasma by GC-MS/MS Combined with Microwave-Assisted Derivatization for Diagnosis of Gastric Disorders

Wonwoong Lee, Hyunjung Lee, You Lee Kim, Yong Chan Lee, Bong Chul Chung and Jongki Hong

IJMS, 2021, 22, 1872
DOI: 10.3390/ijms22041872

Data acquisition workflows in liquid chromatography coupled to high resolution mass spectrometry-based metabolomics: Where do we stand?

François Fenaille, Pierre Barbier Saint-Hilaire, Kathleen Rousseau and Christophe Junot

Journal of Chromatography A, 2017, 1526, 1
DOI: 10.1016/j.chroma.2017.10.043

A rapid, sensitive, and selective liquid chromatography–mass spectrometry method for simultaneous quantification of astragaloside IV and cycloastragenol in mouse plasma and its application to a pharmacokinetic study

Bingshu He, Zhonghua Wang, Lulu Chen, Zhi Zhou and Zeper Abliz

International Journal of Mass Spectrometry, 2018, 434, 130
DOI: 10.1016/j.ijms.2018.09.012

Evaluation of Untargeted Metabolomic Strategy for the Discovery of Biomarker of Breast Cancer

Xujun Ruan, Yan Wang, Lirong Zhou, Qiuling Zheng, Haiping Hao and Dandan He

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.894099

Ring Trial on Quantitative Assessment of Bile Acids Reveals a Method- and Analyte-Specific Accuracy and Reproducibility

Sven-Bastiaan Haange, Andreas Till, Per-Olof Bergh, Günter Fauler, Michael Gigl, Anita Löfgren-Sandblom, Frank G. Schaap, Thomas Clavel, Christian Trautwein, Wiebke Fenske, Karin Kleigrewe, Hanns-Ulrich Marschall, Steven W. M. Olde Damink, Tarek Moustafa, Martin von Bergen and Ulrike Rolle-Kampczyk

Metabolites, 2022, 12, 583
DOI: 10.3390/metabo12070583