Genetically engineered haemoglobin wrapped covalently with human serum albumins as an artificial O2 carrier

Ryosuke Funaki, Wataru Okamoto, Chihiro Endo, Yoshitsugu Morita, Kiyohito Kihira and Teruyuki Komatsu

J. Mater. Chem. B, 2020, 8, 1139
DOI: 10.1039/C9TB02184A

Core–shell protein clusters comprising haemoglobin and recombinant feline serum albumin as an artificial O2carrier for cats

Kyoko Yokomaku, Motofusa Akiyama, Yoshitsugu Morita, Kiyohito Kihira and Teruyuki Komatsu

J. Mater. Chem. B, 2018, 6, 2417
DOI: 10.1039/C8TB00211H

Zinc‐Substituted Hemoglobin–Albumin Cluster as a Porphyrin‐Carrier for Enhanced Photodynamic Therapy

Taiga Yamada, Maho Katsumi, Kota Ishii and Teruyuki Komatsu

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202400257

Human serum albumin as the carrier to fabricate STING-activating peptide nanovaccine for antitumor immunotherapy

Aixian Zheng, Zhaoyu Ning, Xiaorong Wang, Zhenli Li, Yupeng Sun, Ming Wu, Da Zhang, Xiaolong Liu, Jianwu Chen and Yongyi Zeng

Materials Today Bio, 2024, 25, 100955
DOI: 10.1016/j.mtbio.2024.100955

Hemoglobin–albumin clusters as an artificial O2 carrier: Physicochemical properties and resuscitation from hemorrhagic shock in rats

Wataru Okamoto, Mai Hasegawa, Tomone Usui, Tomonori Kashima, Sho Sakata, Tatsuhiko Hamano, Hiroto Onozawa, Ryo Hashimoto, Masayuki Iwazaki, Mitsutomo Kohno and Teruyuki Komatsu

J Biomed Mater Res, 2022, 110, 1827
DOI: 10.1002/jbm.b.35040

Hemoglobin(βC93A)–Albumin Cluster: Mutation of Cysteine‐β93 to Alanine Allows Moderate Reduction of O2 Affinity by Inositol Hexaphosphate

Yoshitsugu Morita, Keisuke Igarashi, Ryosuke Funaki and Teruyuki Komatsu

ChemBioChem, 2019, 20, 1684
DOI: 10.1002/cbic.201900079

Poly(2-ethyl-2-oxazoline)-Conjugated Hemoglobins as a Red Blood Cell Substitute

Wataru Okamoto, Yuuki Hiwatashi, Tatsuhiro Kobayashi, Yoshitsugu Morita, Hiroto Onozawa, Masayuki Iwazaki, Mitsutomo Kohno, Hirotaka Tomiyasu, Ryota Tochinai, Radostina Georgieva, Hans Bäumler and Teruyuki Komatsu

ACS Appl. Bio Mater., 2023, 6, 3330
DOI: 10.1021/acsabm.3c00392

Quaternary Structure Analysis of a Hemoglobin Core in Hemoglobin–Albumin Cluster

Yoshitsugu Morita, Taiga Yamada, Moeka Kureishi, Kiyohito Kihira and Teruyuki Komatsu

J. Phys. Chem. B, 2018, 122, 12031
DOI: 10.1021/acs.jpcb.8b10077

Methemoglobin‐Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy

Taiga Yamada and Teruyuki Komatsu

ChemBioChem, 2021, 22, 2526
DOI: 10.1002/cbic.202100213

Influence of Molecular Structure on O2-Binding Properties and Blood Circulation of Hemoglobin‒Albumin Clusters

Kana Yamada, Kyoko Yokomaku, Risa Haruki, Kazuaki Taguchi, Saori Nagao, Toru Maruyama, Masaki Otagiri, Teruyuki Komatsu and Eugene A. Permyakov

PLoS ONE, 2016, 11, e0149526
DOI: 10.1371/journal.pone.0149526

Hemoglobin–albumin cluster: physiological responses after exchange transfusion into rats and blood circulation persistence in dogs

Hitomi Iwasaki, Kyoko Yokomaku, Moeka Kureishi, Keisuke Igarashi, Ryo Hashimoto, Mitsutomo Kohno, Masayuki Iwazaki, Risa Haruki, Motofusa Akiyama, Kenichi Asai, Yuka Nakamura, Ryosuke Funaki, Yoshitsugu Morita and Teruyuki Komatsu

Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46, 621
DOI: 10.1080/21691401.2018.1505740

Artificial Blood for Dogs

Kana Yamada, Kyoko Yokomaku, Moeka Kureishi, Motofusa Akiyama, Kiyohito Kihira and Teruyuki Komatsu

Sci Rep, 2016, 6
DOI: 10.1038/srep36782

Artificial Viral Capsid Dressed Up with Human Serum Albumin

Kazunori Matsuura and Takahide Honjo

Bioconjugate Chem., 2019, 30, 1636
DOI: 10.1021/acs.bioconjchem.9b00327

Hemoglobin–Albumin Clusters Prepared Using N-Succinimidyl 3-Maleimidopropionate as an Appropriate Cross-Linker

Ryosuke Funaki, Tomonori Kashima, Wataru Okamoto, Sho Sakata, Yoshitsugu Morita, Masayo Sakata and Teruyuki Komatsu

ACS Omega, 2019, 4, 3228
DOI: 10.1021/acsomega.8b03474