The use of isolated natural products as scaffolds for the generation of chemically diverse screening libraries for drug discovery

Emma C. Barnes, Rohitesh Kumar and Rohan A. Davis

Nat. Prod. Rep., 2016, 33, 372
DOI: 10.1039/C5NP00121H

A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer

Vinay Randhawa, Anil Kumar Singh and Vishal Acharya

Mol. BioSyst., 2015, 11, 3362
DOI: 10.1039/C5MB00468C

Domino intramolecular Diels–Alder reactions to construct a 6/6/5/5 fused tetracyclic framework

Gaoyuan Zhao, Min He, Huilin Li, Shuangshuang Duan, Ziyun Yuan, Xingang Xie and Xuegong She

Chem. Commun., 2015, 51, 17321
DOI: 10.1039/C5CC06923H

Non-classical β-carbonic anhydrase inhibitors-towards novel anti-mycobacterials

Natascha von Gnielinski, Lisa Nienaber, Lyndel Mason, Samantha Ellis, James A. Triccas, Rohan A. Davis and Andreas Hofmann

Med. Chem. Commun., 2014, 5, 1563
DOI: 10.1039/C4MD00310A

Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca

Rohitesh Kumar, Sandra Duffy, Vicky M. Avery, Anthony R. Carroll and Rohan A. Davis

J. Nat. Prod., 2018, 81, 1079
DOI: 10.1021/acs.jnatprod.7b00992

Revision of the Phytochemistry of Eremophila sturtii and E. mitchellii

Nicholas J. Sadgrove, Julian Klepp, Sarah V.A.-M. Legendre, Dane Lyddiard, Christopher J. Sumby and Ben W. Greatrex

J. Nat. Prod., 2018, 81, 405
DOI: 10.1021/acs.jnatprod.7b00616

Design and Synthesis of a Screening Library Using the Natural Product Scaffold 3-Chloro-4-hydroxyphenylacetic Acid

Rohitesh Kumar, Martin C. Sadowski, Claire Levrier, Colleen C. Nelson, Amy J. Jones, John P. Holleran, Vicky M. Avery, Peter C. Healy and Rohan A. Davis

J. Nat. Prod., 2015, 78, 914
DOI: 10.1021/np500856u

In vitro biocompatibility and proliferative effects of polar and non-polar extracts of cucurbita ficifolia on human mesenchymal stem cells

Balakrishnan Aristatile and Ghedeir M Alshammari

Biomedicine & Pharmacotherapy, 2017, 89, 215
DOI: 10.1016/j.biopha.2017.02.023

Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis

Claire Levrier, Mélodie Balastrier, Karren D. Beattie, Anthony R. Carroll, Frédéric Martin, Vanida Choomuenwai and Rohan A. Davis

Phytochemistry, 2013, 86, 121
DOI: 10.1016/j.phytochem.2012.09.019

Biomimetic Synthesis of Mitchellenes B–H from the Abundant Biological Precursor 14-Hydroxy-6,12-muuroloadien-15-oic Acid

Julian Klepp, Nicholas J. Sadgrove, Sarah V. A.-M. Legendre, Christopher J. Sumby and Ben W. Greatrex

J. Org. Chem., 2019, 84, 9637
DOI: 10.1021/acs.joc.9b00961

Natural products as lead structures: chemical transformations to create lead-like libraries

Mauro Pascolutti and Ronald J. Quinn

Drug Discovery Today, 2014, 19, 215
DOI: 10.1016/j.drudis.2013.10.013

Antibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca

Emma C. Barnes, Angela M. Kavanagh, Soumya Ramu, Mark A. Blaskovich, Matthew A. Cooper and Rohan A. Davis

Phytochemistry, 2013, 93, 162
DOI: 10.1016/j.phytochem.2013.02.021

Synthesis of a Unique Psammaplysin F Library and Functional Evaluation in Prostate Cancer Cells by Multiparametric Quantitative Single Cell Imaging

Rohitesh Kumar, Charles L. Bidgood, Claire Levrier, Jennifer H. Gunter, Colleen C. Nelson, Martin C. Sadowski and Rohan A. Davis

J. Nat. Prod., 2020, 83, 2357
DOI: 10.1021/acs.jnatprod.0c00121

Potassium Channels: Structures, Diseases, and Modulators

Chuan Tian, Ruixin Zhu, Lixin Zhu, Tianyi Qiu, Zhiwei Cao and Tingguo Kang

Chem Biol Drug Des, 2014, 83, 1
DOI: 10.1111/cbdd.12237

Natural Product Polyamines That Inhibit Human Carbonic Anhydrases

Rohan A. Davis, Daniela Vullo, Claudiu T. Supuran and Sally-Ann Poulsen

BioMed Research International, 2014, 2014, 1
DOI: 10.1155/2014/374079

Synthesis of bilocularin A carbamate derivatives and their evaluation as leucine transport inhibitors in prostate cancer cells

Cohan Huxley, Mario Wibowo, Kah Yean Lum, Shelly Gordon, Sebastian D'Hyon, Hanyu Guan, Xueyi Wang, Yuxi Chen, Mingran Si, Mengchao Wang, Jonathan M. White, Kanu Wahi, Qian Wang, Jeff Holst and Rohan A. Davis

Phytochemistry, 2020, 179, 112478
DOI: 10.1016/j.phytochem.2020.112478

Design, synthesis and spectroscopic characterisation of a focused library based on the polyandrocarpamine natural product scaffold

Paul S. Baron, Juliette E. Neve, David Camp, Lekha Suraweera, Ann Lam, John Lai, Lidija Jovanovic, Colleen Nelson and Rohan A. Davis

Magnetic Reson in Chemistry, 2013, 51, 358
DOI: 10.1002/mrc.3958

Combinatorial Chemistry Online

N.K. Terrett

Combinatorial Chemistry - an Online Journal, 2012, 14, 25
DOI: 10.1016/j.comche.2012.05.002

Identification of Gibberellic Acid Derivatives That Deregulate Cholesterol Metabolism in Prostate Cancer Cells

Folake A. Egbewande, Martin C. Sadowski, Claire Levrier, Kaylyn D. Tousignant, Jonathan M. White, Mark J. Coster, Colleen C. Nelson and Rohan A. Davis

J. Nat. Prod., 2018, 81, 838
DOI: 10.1021/acs.jnatprod.7b00929

Prospecting for Novel Plant-Derived Molecules of Rauvolfia serpentina as Inhibitors of Aldose Reductase, a Potent Drug Target for Diabetes and Its Complications

Shivalika Pathania, Vinay Randhawa, Ganesh Bagler and Jie Zheng

PLoS ONE, 2013, 8, e61327
DOI: 10.1371/journal.pone.0061327

The design, synthesis, and anti-inflammatory evaluation of a drug-like library based on the natural product valerenic acid

Folake A. Egbewande, Niclas Nilsson, Jonathan M. White, Mark J. Coster and Rohan A. Davis

Bioorganic & Medicinal Chemistry Letters, 2017, 27, 3185
DOI: 10.1016/j.bmcl.2017.05.021

Copper porphyrin‐catalyzed C(sp2)—O bond construction via coupling phenols with formamides

Shuang Yang, Xiao‐Yan Chen, Ming‐Feng Xiong, Hao Zhang, Lei Shi, Dong‐Zi Lin and Hai‐Yang Liu

J Chinese Chemical Soc, 2021, 68, 1541
DOI: 10.1002/jccs.202100046

En Route to Diastereopure Polycyclic γ‐Lactones by Iridium‐Catalyzed Hydride Transfer†

Yang Chen, Jingyu Zhang, Yecheng Wang, Hongguang Du, Jiaxi Xu and Zhanhui Yang

Chin. J. Chem., 2024, 42, 3047
DOI: 10.1002/cjoc.202400265

SerpentinaDB: a database of plant-derived molecules of Rauvolfia serpentina

Shivalika Pathania, Sai Mukund Ramakrishnan, Vinay Randhawa and Ganesh Bagler

BMC Complement Altern Med, 2015, 15
DOI: 10.1186/s12906-015-0683-7

Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold

Chen Zhang, Kah Yean Lum, Aya C. Taki, Robin B. Gasser, Joseph J. Byrne, Tao Wang, Mark A.T. Blaskovich, Emery T. Register, Luis J. Montaner, Ian Tietjen and Rohan A. Davis

Phytochemistry, 2021, 190, 112887
DOI: 10.1016/j.phytochem.2021.112887

Anti Mtb Medicinal Plants Database (AMMPDB): A curated database of Indian anti-tubercular medicinal plants

Jithisree Kanneganti, Usha Mina, Ankita Singh, Anuradha Gautam and Pallavi Somvanshi

Journal of Ayurveda and Integrative Medicine, 2023, 14, 100712
DOI: 10.1016/j.jaim.2023.100712

Library Construction and Biological Evaluation of Enmein‐Type Diterpenoid Analogues as Potential Anticancer Agents

Dahong Li, Shengtao Xu, Hao Cai, Lingling Pei, Lei Wang, Xiaoming Wu, Hequan Yao, Jieyun Jiang, Yijun Sun and Jinyi Xu

ChemMedChem, 2013, 8, 812
DOI: 10.1002/cmdc.201200559

The discovery, synthesis and antimalarial evaluation of natural product-based polyamine alkaloids

Vanida Choomuenwai, Brett D. Schwartz, Karren D. Beattie, Katherine T. Andrews, Shahan Khokhar and Rohan A. Davis

Tetrahedron Letters, 2013, 54, 5188
DOI: 10.1016/j.tetlet.2013.07.058

Reaction of Papaverine with Baran DiversinatesTM

Folake A. Egbewande, Mark J. Coster, Ian D. Jenkins and Rohan A. Davis

Molecules, 2019, 24, 3938
DOI: 10.3390/molecules24213938

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2

Anna Vuorinen, Roger T. Engeli, Susanne Leugger, Fabio Bachmann, Muhammad Akram, Atanas G. Atanasov, Birgit Waltenberger, Veronika Temml, Hermann Stuppner, Liselotte Krenn, Sylvin B. Ateba, Dieudonné Njamen, Rohan A. Davis, Alex Odermatt and Daniela Schuster

J. Nat. Prod., 2017, 80, 965
DOI: 10.1021/acs.jnatprod.6b00950

Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold

Vanida Choomuenwai, Katherine T. Andrews and Rohan A. Davis

Bioorganic & Medicinal Chemistry, 2012, 20, 7167
DOI: 10.1016/j.bmc.2012.09.052

Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations

Chen Zhang, Kah Yean Lum, Aya C. Taki, Robin B. Gasser, Joseph J. Byrne, Luis J. Montaner, Ian Tietjen, Vicky M. Avery and Rohan A. Davis

J. Nat. Prod., 2023, 86, 557
DOI: 10.1021/acs.jnatprod.2c01041

Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid

Rohitesh Kumar, Sandra Duffy, Vicky M. Avery and Rohan A. Davis

Bioorganic & Medicinal Chemistry Letters, 2017, 27, 4091
DOI: 10.1016/j.bmcl.2017.07.039