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Metal–organic supercontainers (MOSCs) represent a new family of synthetic receptors derived from container precursors and featuring both endo and exo cavities. A neutral MOSC has been functionalized into an anionic container by incorporating sulfo groups. The anionic MOSC exhibits cavity-specific binding properties in both solid state and solution.

Graphical abstract: Modulating guest binding in sulfonylcalixarene-based metal–organic supercontainers

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