Breaking the energy chain: importance of ATP synthase in Mycobacterium tuberculosis and its potential as a drug target
Inhibitors of mycobacterial ATP synthase, such as bedaquiline, TBAJ-587, TBAJ-876, squaramides, GaMF1, and DeMF1, break the energy metabolism and effectively inhibit Mtb, offering promising strategies against mycobacterial infections.
Advances in the development of Wnt/β-catenin signaling inhibitors
The Wnt/β-catenin signaling pathway plays a critical role in various biological processes, including cell proliferation, differentiation, and tissue homeostasis.
Probing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study
Short MD simulations help identify the putative bioactive conformation of small molecule agonists at the NOP receptor providing useful information for the structure-based design of novel analgesic drugs.
Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
Several fused-thiazole derivatives have been studied for antimelanoma properties. Lead compounds are effective tumor growth inhibitors in mice, which are potent β- and γ-actin cytoskeleton inhibitors with a probable mechanism of β-PARVIN inhibition.
Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
About this collection
This collection brings together all of the research and review-type articles behind our 2025 journal covers, showcasing the wide range of research found in the journal. If your article has been accepted for publication, and you are interested in highlighting your research on one of our covers, please do contact the Editorial Team for further information.