An electrochemical chiral sensing platform based on a multi-substituted ferrocene–Cu+ complex is constructed for the discrimination of electroactive amino acid isomers.
A strain-release promoted cycloaddition opens-up access to carbonyl conjugated allylic diborons and borylated homoallylic alcohols, β-spiro lactones and γ-butyrolactones having adjacent quaternary, tertiary and secondary stereocenters.
The reactivity of the strain-increase allylboration with vinylcyclopropyl boronic esters is affected by both the electronic property of the cyclopropyl substituent and the acidity of the boron center.
An enantio- and diastereoselective allylboration of sterically hindered aldehydes utilizing multiple hydrogen bonding interactions between chiral phosphoramide catalyst has been established.
Two cascade processes based on asymmetric aldehyde allylboration by a chiral phosphoric acid catalyst have been established for creating chiral multisubstituted tetrahydropyrans.