Thermal proteome profiling of itaconate interactome in macrophages

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Chem. Sci., 2025, 16, 13838
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Discovery of Itaconate-Mediated Lysine Acylation

Dongyang Liu, Weidi Xiao, Haoting Li, Yanling Zhang, Shouli Yuan, Chengxi Li, Suwei Dong and Chu Wang

J. Am. Chem. Soc., 2023, 145, 12673
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Target Fishing Reveals a Novel Mechanism of N-Acylamino Saccharin Derivatives Targeting Glyceraldehyde-3-Phosphate Dehydrogenase toward Cyanobacterial Blooms Control

Hongxuan Cao, Zeyue Huang, Zheng Liu, Muhammad Salman Hameed, Jian Wan, Li Rao, Nokwanda P. Makunga, Georgi M. Dobrikov, Chen Su, Chao Peng and Yanliang Ren

J. Agric. Food Chem., 2024, 72, 21393
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Metabolic control of neuroinflammation: focus on itaconate and its derivatives in CNS disorders

Ying Wang, Shihui Liu, Weijie Zhu, Pengyu Hao, Jiacan Xu, Diqi Mai, Ran Chen, Haojie Han, Xuechen Bian and Bodong Wang

Front. Immunol., 2026, 17
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Staphylococcus aureus adaptive evolution: Recent insights on how immune evasion, immunometabolic subversion and host genetics impact vaccine development

Tania Wong Fok Lung, Liana C. Chan, Alice Prince, Michael R. Yeaman, Nathan K. Archer, M. Javad Aman and Richard A. Proctor

Front. Cell. Infect. Microbiol., 2022, 12
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Integrated Mass Spectrometry Reveals Celastrol As a Novel Catechol-O-methyltransferase Inhibitor

Haijun Guo, Yang Yang, Qi Zhang, Jie-Ren Deng, Ying Yang, Shuqi Li, Pui-Kin So, Thomas C. Lam, Man-kin Wong and Qian Zhao

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A host-pathogen metabolic synchrony that facilitates disease tolerance

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Nat Commun, 2025, 16
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Activity-based protein profiling in microbes and the gut microbiome

Lin Han and Pamela V. Chang

Current Opinion in Chemical Biology, 2023, 76, 102351
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Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa

Qin Huang, Chenxi Duan, Haichuan Ma, Cheng Nong, Qianqian Zheng, Jun Zhou, Ninglin Zhao, Xingyu Mou, Tonggen Liu, Shuang Zou, Ningchuan Yang, Aiping Tong, Wenming Qin and Rui Bao

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Itaconate modifications: Mechanisms and applications

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Site‐Selective Itaconation of Complex Peptides by Photoredox Catalysis

Siyao Wang, QingQing Zhou, Xiaheng Zhang and Ping Wang

Angewandte Chemie, 2022, 134
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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, Maria A. Argiriadi, Anne F. McGettrick, Rui Santalla Mendez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Y. Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang and Luke A.J. O’Neill

Cell Metabolism, 2022, 34, 487
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Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia

Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri, Zhe Liu, Ridhima Wadhwa, Gustavo Rios, Henning Henschel, Nupur Tyagi, Françios A. B. Olivier, Ian R. Monk, Shivang S. Shah, Shwetha H. Sridhar, Marija Drikic, Colleen Bianco, Gaurav K. Lohia, Ayesha Z. Beg, Paul J. Planet, Ian A. Lewis, Robert Sebra, Ana Traven, Abderrahman Hachani, Timothy P. Stinear, Benjamin P. Howden, Jeffrey M. Boyd, Sebastian A. Riquelme, Chu Wang, Alice Prince and Tania Wong Fok Lung

Nat Commun, 2025, 16
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Quantitative Chemoproteomic Methods for Reactive Cysteinome Profiling

Weidi Xiao, Ying Chen and Chu Wang

Israel Journal of Chemistry, 2023, 63
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The role and therapeutic potential of itaconate in lung disease

Ruyuan He, Yifan Zuo, Ke Yi, Bohao Liu, Congkuan Song, Ning Li and Qing Geng

Cell Mol Biol Lett, 2024, 29
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Functional Proteomics Driven by Chemical and Computational Approaches

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Chemoproteomic Approaches for Unraveling Prokaryotic Biology

Kien P. Malarney and Pamela V. Chang

Israel Journal of Chemistry, 2023, 63
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Emerging trends in chemoproteomics: Mapping the landscape of protein–metabolite interactions

Ning Wan, Chenguang Liu, Haiping Hao and Hui Ye

Current Opinion in Chemical Biology, 2025, 89, 102631
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Chemical Proteomics Probes: Classification, Applications, and Future Perspectives in Proteome‐Wide Studies

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Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity

Haoyun Chang, Ruiying Ji, Zhiyu Zhu, Yapin Wang, Shaopeng Yan, Dan He, Qike Jia, Peng Huang, Tao Cheng, Rui Wang and Yang Zhou

European Journal of Medicinal Chemistry, 2024, 265, 116064
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Reprogramming immunity with itaconate: metabolic mechanisms and therapeutic perspectives

Hanlin Gao, Minting Ding, Yunchen Liu, Yiying Wang, Susu Zhao, Junyao Chen, Zhi Chen and Gang Wang

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Quantitative profiling of PTM stoichiometry by DNA mass tags

Yuanpei Li, Yuan Liu and Chu Wang

Bioorganic & Medicinal Chemistry, 2025, 118, 118050
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Bioorthogonal Probes for Analyzing Non‐Enzymatic Post‐Translational Modifications

Zhentao Shao, Yingdi Zhu and Juan Li

ChemBioChem, 2023, 24
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CysModDB: a comprehensive platform with the integration of manually curated resources and analysis tools for cysteine posttranslational modifications

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Site‐Selective Itaconation of Complex Peptides by Photoredox Catalysis

Siyao Wang, QingQing Zhou, Xiaheng Zhang and Ping Wang

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Immunometabolic control by Klebsiella pneumoniae

Alice Prince and Tania Wong Fok Lung

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Click-chemistry-based protocol for detecting 4-octyl-itaconate-alkylated proteins in primary mouse macrophages

Chaofei Su, Tian Cheng, Hanyi Zhang and Hang Yin

STAR Protocols, 2024, 5, 103314
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Progress and application of activity-based protein profiling for the discovery of natural product targets

Jinfang Qin, Shun Zhang, Yongyi Pan, Xiaocan Lei, Zhenwei Guo, Qin Xie, Kongwei Huang and Peng Huo

Mol Divers, 2025
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In situ global proteomics profiling of EGCG targets using a cell-permeable and Click-able bioorthogonal probe

Revathy Sahadevan, Anupama Binoy, Sai K. Vechalapu, Pandurangan Nanjan and Sushabhan Sadhukhan

International Journal of Biological Macromolecules, 2023, 237, 123991
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Staphylococcus aureus adapts to the immunometabolite itaconic acid by inducing acid and oxidative stress responses including S-bacillithiolations and S-itaconations

Vu Van Loi, Tobias Busche, Benno Kuropka, Susanne Müller, Karen Methling, Michael Lalk, Jörn Kalinowski and Haike Antelmann

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Decarboxylative Coupling of Ketoacids with Allylic Acetates

Xiaoyu Zhang, Fanyi Hou, Yinlei Zhang, Bowen Li, Peizhong Xie and Teck-Peng Loh

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In situ chemoproteomic profiling reveals itaconate inhibits de novo purine biosynthesis in pathogens

Zihua Liu, Dongyang Liu and Chu Wang

Cell Reports, 2024, 43, 114737
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Structural insight into the unexploited allosteric binding site of fructose 1, 6-bisphosphate aldolase from C. albicans with α-lipoic acid

Hongxuan Cao, Zeyue Huang, Xiuqi Hu, Xiao Zhang, Nokwanda P. Makunga, Hui Zhao, Liji Du, Li Guo and Yanliang Ren

International Journal of Biological Macromolecules, 2025, 309, 143096
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Chemoproteomic mapping of the glycolytic targetome in cancer cells

Yang Tian, Ning Wan, Hanqing Zhang, Chang Shao, Ming Ding, Qiuyu Bao, Haiyang Hu, Huiyong Sun, Chenguang Liu, Kun Zhou, Shuai Chen, Guangji Wang, Hui Ye and Haiping Hao

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Dissecting S-itaconation at host–pathogen interactions with chemical proteomics tools

Zihua Liu and Chu Wang

Current Opinion in Microbiology, 2025, 83, 102579
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