Success stories of natural product-derived compounds from plants as multidrug resistance modulators in microorganisms

Xiaohan Zhai, Guoyu Wu, Xufeng Tao, Shilei Yang, Linlin Lv, Yanna Zhu, Deshi Dong and Hong Xiang

RSC Adv., 2023, 13, 7798
DOI: 10.1039/D3RA00184A

The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide

Fernando Baquero, Konstantinos Beis, David J. Craik, Yanyan Li, A. James Link, Sylvie Rebuffat, Raúl Salomón, Konstantin Severinov, Séverine Zirah and Julian D. Hegemann

Nat. Prod. Rep., 2024, 41, 469
DOI: 10.1039/D3NP00046J

Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides

Chayanid Ongpipattanakul, Emily K. Desormeaux, Adam DiCaprio, Wilfred A. van der Donk, Douglas A. Mitchell and Satish K. Nair

Chem. Rev., 2022, 122, 14722
DOI: 10.1021/acs.chemrev.2c00210

Recent Advances in Discovery, Bioengineering, and Bioactivity-Evaluation of Ribosomally Synthesized and Post-translationally Modified Peptides

Guannan Zhong, Zong-Jie Wang, Fu Yan, Youming Zhang and Liujie Huo

ACS Bio Med Chem Au, 2023, 3, 1
DOI: 10.1021/acsbiomedchemau.2c00062

Interventions in Nicotinamide Adenine Dinucleotide Metabolism, the Intestinal Microbiota and Microcin Peptide Antimicrobials

Fernando Baquero, Rosa del Campo and José-Luis Martínez

Front. Mol. Biosci., 2022, 9
DOI: 10.3389/fmolb.2022.861603

Mobilome-mediated transcriptional activation of biosynthetic gene clusters and its impact on strain competitiveness in food fermentation microbiomes

Lei Xu, Jian-Yu Jiao, Chen Ling, Ru-Bing Du, Qun Wu, Yan Xu and Wen-Jun Li

Microbiome, 2025, 13
DOI: 10.1186/s40168-025-02180-0

Exploring the Diverse Landscape of Biaryl-Containing Peptides Generated by Cytochrome P450 Macrocyclases

Hyunsung Nam, Joon Soo An, Jaepil Lee, Yonghwan Yun, Hyunbin Lee, Hyungou Park, Yousung Jung, Ki-Bong Oh, Dong-Chan Oh and Seokhee Kim

J. Am. Chem. Soc., 2023, 145, 22047
DOI: 10.1021/jacs.3c07140

Antimicrobial peptides: Sustainable application informed by evolutionary constraints

Xuan Chen, Jinzhi Han, Xixi Cai and Shaoyun Wang

Biotechnology Advances, 2022, 60, 108012
DOI: 10.1016/j.biotechadv.2022.108012

Dual-Uptake Mode of the Antibiotic Phazolicin Prevents Resistance Acquisition by Gram-Negative Bacteria

Dmitrii Y. Travin, Romain Jouan, Armelle Vigouroux, Satomi Inaba-Inoue, Joy Lachat, Fazal Haq, Tatiana Timchenko, Dmitry Sutormin, Svetlana Dubiley, Konstantinos Beis, Solange Moréra, Konstantin Severinov, Peter Mergaert and Edward W. Yu

mBio, 2023, 14
DOI: 10.1128/mbio.00217-23

Ti-MOF-based biosafety materials for efficient and long-life disinfection via synergistic photodynamic and photothermal effects

Lan Xie, Heng Yang, Xizheng Wu, Liyun Wang, Bihui Zhu, Yuanjiao Tang, Mingru Bai, Ling Li, Chong Cheng and Tian Ma

Biosafety and Health, 2022, 4, 135
DOI: 10.1016/j.bsheal.2022.02.001

Naturally occurring lasso peptides as algicidal agents against Microcystis aeruginosa

Yan-Hua Zeng, Zhong-Hua Cai, Ke-Ke Cheng and Jin Zhou

Journal of Cleaner Production, 2022, 381, 135136
DOI: 10.1016/j.jclepro.2022.135136

Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity

Xiaotong Wang, Xiaoyu Chen, Zong-Jie Wang, Mengwei Zhuang, Lin Zhong, Chengzhang Fu, Ronald Garcia, Rolf Müller, Youming Zhang, Jie Yan, Dalei Wu and Liujie Huo

J. Am. Chem. Soc., 2023, 145, 16924
DOI: 10.1021/jacs.3c06014

SPI “sandwich”: Combined SUMO‐Peptide‐Intein expression system and isolation procedure for improved stability and yield of peptides

Tess Lamer, Marco J. van Belkum, Anjalee Wijewardane, Sorina Chiorean, Leah A. Martin‐Visscher and John C. Vederas

Protein Science, 2022, 31
DOI: 10.1002/pro.4316

Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry

José Carlos Parada Fabián, Ana Karen Álvarez Contreras, Iván Natividad Bonifacio, Marcos Francisco Hernández Robles, Carlos Ramón Vázquez Quiñones, Elsa Irma Quiñones Ramírez and Carlos Vázquez Salinas

Bioscience Reports, 2025, 45, 277
DOI: 10.1042/BSR20241594

Antimicrobial peptides: An alternative to traditional antibiotics

Shuaiqi Ji, Feiyu An, Taowei Zhang, Mengxue Lou, Jiawei Guo, Kexin Liu, Yi Zhu, Junrui Wu and Rina Wu

European Journal of Medicinal Chemistry, 2024, 265, 116072
DOI: 10.1016/j.ejmech.2023.116072

A comprehensive review of microorganism‐derived cyclic peptides: Bioactive functions and food safety applications

Jiaqi Luo, Siyu Liu, Hongyun Lu, Qihe Chen and Ying Shi

Comp Rev Food Sci Food Safe, 2022, 21, 5272
DOI: 10.1111/1541-4337.13038

Streamlining N-terminally anchored yeast surface display via structural insights into S. cerevisiae Pir proteins

Tea Martinić Cezar, Mateja Lozančić, Ana Novačić, Ana Matičević, Dominik Matijević, Béatrice Vallée, Vladimir Mrša, Renata Teparić and Bojan Žunar

Microb Cell Fact, 2023, 22
DOI: 10.1186/s12934-023-02183-2

Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice

Sabine Kienesberger, Amar Cosic, Maksym Kitsera, Sandra Raffl, Marlene Hiesinger, Eva Leitner, Bettina Halwachs, Gregor Gorkiewicz, Ronald A. Glabonjat, Georg Raber, Christian Lembacher-Fadum, Rolf Breinbauer, Stefan Schild and Ellen L. Zechner

Nat Microbiol, 2022, 7, 1834
DOI: 10.1038/s41564-022-01260-3

Cloacaenodin, an Antimicrobial Lasso Peptide with Activity against Enterobacter

Drew V. Carson, Monica Patiño, Hader E. Elashal, Alexis Jaramillo Cartagena, Yi Zhang, Megan E. Whitley, Larry So, Angelo K. Kayser-Browne, Ashlee M. Earl, Roby P. Bhattacharyya and A. James Link

ACS Infect. Dis., 2023, 9, 111
DOI: 10.1021/acsinfecdis.2c00446

Advances in lasso peptide discovery, biosynthesis, and function

Susanna E. Barrett and Douglas A. Mitchell

Trends in Genetics, 2024, 40, 950
DOI: 10.1016/j.tig.2024.08.002

Proteases Involved in Leader Peptide Removal during RiPP Biosynthesis

Sara M. Eslami and Wilfred A. van der Donk

ACS Bio Med Chem Au, 2024, 4, 20
DOI: 10.1021/acsbiomedchemau.3c00059

Emerging chemophysiological diversity of gut microbiota metabolites

Xiaorong Lin, Kaixin He, Zhen Gu and Xiaohui Zhao

Trends in Pharmacological Sciences, 2024, 45, 824
DOI: 10.1016/j.tips.2024.07.006

Et tu, Neisseria? Conflicts of Interest Between Neisseria Species

Rene Baerentsen, Christoph M. Tang and Rachel M. Exley

Front. Cell. Infect. Microbiol., 2022, 12
DOI: 10.3389/fcimb.2022.913292

Evidence for Widespread Class II Microcins in Enterobacterales Genomes

T. Jeffrey Cole, Jennifer K. Parker, Aaron L. Feller, Claus O. Wilke, Bryan W. Davies and Jeremy D. Semrau

Appl Environ Microbiol, 2022, 88
DOI: 10.1128/aem.01486-22

Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain

Nikunj Maheshwari, Lars S. Jermiin, Chiara Cotroneo, Stephen V. Gordon and Denis C. Shields

R. Soc. Open Sci., 2024, 11
DOI: 10.1098/rsos.240491

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome

Pascal Hirsch, Azat Tagirdzhanov, Aleksandra Kushnareva, Ilia Olkhovskii, Simon Graf, Georges P Schmartz, Julian D Hegemann, Kenan A J Bozhüyük, Rolf Müller, Andreas Keller and Alexey Gurevich

Nucleic Acids Research, 2024, 52, D579
DOI: 10.1093/nar/gkad1086

Structural Basis of Pore Formation in the Mannose Phosphotransferase System by Pediocin PA-1

Liyan Zhu, Jianwei Zeng, Chang Wang, Jiawei Wang and Nicole R. Buan

Appl Environ Microbiol, 2022, 88
DOI: 10.1128/AEM.01992-21

Genomic insights into antimicrobial potential and optimization of fermentation conditions of pig-derived Bacillus subtilis BS21

Di Wu, Linglong Fu, Yunhe Cao, Na Dong and Defa Li

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1239837

Microbial-derived peptides with anti-mycobacterial potential

Pengchao Zhao, Pu Hou, Zhishen Zhang, Xin Li, Chunshan Quan, Yun Xue, Kun Lei, Jinghua Li, Weina Gao and Fangfang Fu

European Journal of Medicinal Chemistry, 2024, 276, 116687
DOI: 10.1016/j.ejmech.2024.116687

Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking of Ortho-Tyrosines

Chandrashekhar Padhi, Lingyang Zhu, Jeff Y. Chen, Chuan Huang, Ryan Moreira, Gregory L. Challis, Max J. Cryle and Wilfred A. van der Donk

J. Am. Chem. Soc., 2025, 147, 23781
DOI: 10.1021/jacs.5c06044

A Bird’s-Eye View of the Pathophysiologic Role of the Human Urobiota in Health and Disease: Can We Modulate It?

Emilio Jirillo, Raffaele Palmirotta, Marica Colella and Luigi Santacroce

Pathophysiology, 2024, 31, 52
DOI: 10.3390/pathophysiology31010005

The human microbiome-derived antimicrobial lugdunin self-regulates its biosynthesis by a feed-forward mechanism

Leonie Reetz, Lukas Schulze, Thales Kronenberger, Khaled A. Selim, Timm Schaefle, Taulant Dema, Alexander Zipperer, Jens Mößner, Antti Poso, Stephanie Grond, Andreas Peschel, Bernhard Krismer and Katherine P. Lemon

mBio, 2025, 16
DOI: 10.1128/mbio.03571-24

Large-scale biosynthetic analysis of human microbiomes reveals diverse protective ribosomal peptides

Jian Zhang, Dengwei Zhang, Yi Xu, Junliang Zhang, Runze Liu, Ying Gao, Yuqi Shi, Peiyan Cai, Zheng Zhong, Beibei He, Xuechen Li, Hongwei Zhou, Muxuan Chen and Yong-Xin Li

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-58280-w