Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum(iv) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple negative breast cancer cells

Nada K. Sedky, Maria Braoudaki, Noha Khalil Mahdy, Kenzy Amin, Iten M. Fawzy, Eleni K. Efthimiadou, Rana A. Youness and Sherif Ashraf Fahmy

Nanoscale Adv., 2023, 5, 5399
DOI: 10.1039/D3NA00368J

Novel half-sandwich iridium(iii) imino-pyridyl complexes showing remarkable in vitro anticancer activity

JuanJuan Li, Lihua Guo, Zhenzhen Tian, Meng Tian, Shumiao Zhang, Ke Xu, Yuchuan Qian and Zhe Liu

Dalton Trans., 2017, 46, 15520
DOI: 10.1039/C7DT03265J

Fifth International Symposium on Metallomics 2015

Metallomics, 2016, 8, 641
DOI: 10.1039/C6MT90027E

Multi-specific niflumic acid platinum(iv) complexes displaying potent antitumor activities by improving immunity and suppressing angiogenesis besides causing DNA damage

Linming Li, Ming Zhang, Dianlong Jia, Zhifang Liu, Ning Zhang, Bin Sun, Zhengping Wang, Min Liu and Qingpeng Wang

Dalton Trans., 2023, 52, 147
DOI: 10.1039/D2DT03246E

Pt(iv) derivatives of cisplatin and oxaliplatin bearing an EMT-related TMEM16A/COX-2-selective dual inhibitor against colorectal cancer cells HCT116

Zhong-Ying Ma, Xiao-Jing Ding, Zhen-Zhen Zhu, Qian Chen, Dong-Bo Wang, Xin Qiao and Jing-Yuan Xu

RSC Med. Chem., 2024, 15, 3239
DOI: 10.1039/D4MD00327F

Naproxen platinum(iv) hybrids inhibiting cycloxygenases and matrix metalloproteinases and causing DNA damage: synthesis and biological evaluation as antitumor agents in vitro and in vivo

Yan Chen, Qingpeng Wang, Zuojie Li, Zhifang Liu, Yanna Zhao, Junfeng Zhang, Min Liu, Zhengping Wang, Dacheng Li and Jun Han

Dalton Trans., 2020, 49, 5192
DOI: 10.1039/D0DT00424C

Novel hybrids derived from aspirin and chalcones potently suppress colorectal cancer in vitro and in vivo

Shan Lu, Obinna N. Obianom and Yong Ai

Med. Chem. Commun., 2018, 9, 1722
DOI: 10.1039/C8MD00284C

Development of a series of flurbiprofen and zaltoprofen platinum(iv) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA

Zuojie Li, Linming Li, Wenhuan Zhao, Bin Sun, Zhifang Liu, Min Liu, Jun Han, Zhengping Wang, Dacheng Li and Qingpeng Wang

Dalton Trans., 2022, 51, 12604
DOI: 10.1039/D2DT00944G

Synthesis and Anticancer Activity Evaluation of Hydrolyzed Derivatives of Panaxnotoginseng Saponins

Lei Xu, Shengnan Xiao, Weihui Yuan, Jiongmo Cui, Guangyue Su and Yuqing Zhao

Molecules, 2018, 23, 3021
DOI: 10.3390/molecules23113021

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects

Hana Kostrhunova, Emanuele Petruzzella, Dan Gibson, Jana Kasparkova and Viktor Brabec

Chemistry A European J, 2019, 25, 5235
DOI: 10.1002/chem.201805626

Cisplatin-modified isonicotinic acid as a potential linker in bio-MOFs: synthesis and characterization

Venansia Avelia Rosari, Witri Wahyu Lestari and Maulidan Firdaus

Res Chem Intermed, 2019, 45, 3155
DOI: 10.1007/s11164-019-03784-6

Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway

Jincan Chen, Jie Wang, Yuanyuan Deng, Tao Wang, Tifang Miao, Chengpeng Li, Xianhong Cai, Ying Liu, Justin Henri and Lanmei Chen

Bioinorganic Chemistry and Applications, 2020, 2020, 1
DOI: 10.1155/2020/8890950

Application of Metal Compounds in Medicine

E. R. Milaeva

Russ J Coord Chem, 2024, 50, 1043
DOI: 10.1134/S1070328424600815

Cytotoxic ruthenium(II) polypyridyl complexes with naproxen as NSAID: Synthesis, biological interactions and antioxidant activity

Payal Srivastava, Ramranjan Mishra, Madhu Verma, Sri Sivakumar and Ashis K. Patra

Polyhedron, 2019, 172, 132
DOI: 10.1016/j.poly.2019.04.009

Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells

Hana Kostrhunova, Brondwyn S. McGhie, Lenka Markova, Olga Novakova, Jana Kasparkova, Janice R. Aldrich-Wright and Viktor Brabec

J. Med. Chem., 2023, 66, 7894
DOI: 10.1021/acs.jmedchem.3c00269

Top-down mass spectrometry reveals multiple interactions of an acetylsalicylic acid bearing Zeise’s salt derivative with peptides

Monika Cziferszky and Ronald Gust

J Biol Inorg Chem, 2020, 25, 285
DOI: 10.1007/s00775-020-01760-9

Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects

Francesco Paolo Intini, Juraj Zajac, Vojtech Novohradsky, Teresa Saltarella, Concetta Pacifico, Viktor Brabec, Giovanni Natile and Jana Kasparkova

Inorg. Chem., 2017, 56, 1483
DOI: 10.1021/acs.inorgchem.6b02553

Pt(IV) Complexes in the Search for Novel Platinum Prodrugs with Promising Activity

Sainath Aher, Jinhua Zhu, Pundlik Bhagat, Laxmikant Borse and Xiuhua Liu

Top Curr Chem (Z), 2024, 382
DOI: 10.1007/s41061-023-00448-3

New Formulation of a Methylseleno-Aspirin Analog with Anticancer Activity Towards Colon Cancer

Ana Carolina Ruberte, Gustavo González-Gaitano, Arun K. Sharma, Carlos Aydillo, Ignacio Encío, Carmen Sanmartín and Daniel Plano

IJMS, 2020, 21, 9017
DOI: 10.3390/ijms21239017

Differential Gene Regulatory Network Analysis between Azacitidine-Sensitive and -Resistant Cell Lines

Heewon Park and Satoru Miyano

IJMS, 2024, 25, 3302
DOI: 10.3390/ijms25063302

Sustainable Nanomedicine: Enhancement of Asplatin’s Cytotoxicity In Vitro and In Vivo Using Green-Synthesized Zinc Oxide Nanoparticles Formed via Microwave-Assisted and Gambogic Acid-Mediated Processes

Hatem A. F. M. Hassan, Nada K. Sedky, Mohamed S. Nafie, Noha Khalil Mahdy, Iten M. Fawzy, Toka Waleed Fayed, Eduard Preis, Udo Bakowsky and Sherif Ashraf Fahmy

Molecules, 2024, 29, 5327
DOI: 10.3390/molecules29225327

Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)

Venansia Avelia Rosari, Witri Wahyu Lestari and Maulidan Firdaus

Chem. Pap., 2020, 74, 2733
DOI: 10.1007/s11696-020-01114-4

Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells

Subhendu Karmakar, Hana Kostrhunova, Tereza Ctvrtlikova, Vojtech Novohradsky, Dan Gibson and Viktor Brabec

J. Med. Chem., 2020, 63, 13861
DOI: 10.1021/acs.jmedchem.0c01400

NSAIDs: Old Acquaintance in the Pipeline for Cancer Treatment and Prevention─Structural Modulation, Mechanisms of Action, and Bright Future

Sandra Ramos-Inza, Ana Carolina Ruberte, Carmen Sanmartín, Arun K. Sharma and Daniel Plano

J. Med. Chem., 2021, 64, 16380
DOI: 10.1021/acs.jmedchem.1c01460

Dual-Action Pt(IV) Prodrugs and Targeted Delivery in Metal-Organic Frameworks: Overcoming Cisplatin Resistance and Improving Anticancer Activity

Larasati Larasati, Witri Wahyu Lestari and Maulidan Firdaus

Bulletin of the Chemical Society of Japan, 2022, 95, 1561
DOI: 10.1246/bcsj.20220218

Platinum(IV) Prodrugs – A Step Closer to Ehrlich's Vision?

Reece G. Kenny, Su Wen Chuah, Alanna Crawford and Celine J. Marmion

Eur J Inorg Chem, 2017, 2017, 1596
DOI: 10.1002/ejic.201601278

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo

Xue-Qing Song, Zhong-Ying Ma, Yi-Gang Wu, Miao-Liang Dai, Dong-Bo Wang, Jing-Yuan Xu and Yangzhong Liu

European Journal of Medicinal Chemistry, 2019, 167, 377
DOI: 10.1016/j.ejmech.2019.02.041

Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway

Ran Zhang, Yueyue Zhang, Xiangdong Xin, Gaiqun Huang, Ning Zhang, Qinglei Zeng, Liumei Tang, Thomas Attaribo, Kwang Sik Lee, Byung Rae Jin and Zhongzheng Gui

J. Nat. Prod., 2021, 84, 1534
DOI: 10.1021/acs.jnatprod.1c00014

Anticancer IrIII–Aspirin Conjugates for Enhanced Metabolic Immuno‐Modulation and Mitochondrial Lifetime Imaging

Xiao‐Wen Wu, Yue Zheng, Fang‐Xin Wang, Jian‐Jun Cao, Hang Zhang, Dong‐Yang Zhang, Cai‐Ping Tan, Liang‐Nian Ji and Zong‐Wan Mao

Chemistry A European J, 2019, 25, 7012
DOI: 10.1002/chem.201900851

A view on multi-action Pt(IV) antitumor prodrugs

Mauro Ravera, Elisabetta Gabano, Michael J. McGlinchey and Domenico Osella

Inorganica Chimica Acta, 2019, 492, 32
DOI: 10.1016/j.ica.2019.04.025

Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen †

Mauro Ravera, Ilaria Zanellato, Elisabetta Gabano, Elena Perin, Beatrice Rangone, Marco Coppola and Domenico Osella

IJMS, 2019, 20, 3074
DOI: 10.3390/ijms20123074

Aspirin-inspired organometallic compounds: Structural characterization and cytotoxicity

Adnan Ashraf, Muhammad Hanif, Mario Kubanik, Tilo Söhnel, Stephen M.F. Jamieson, Arindam Bhattacharyya and Christian G. Hartinger

Journal of Organometallic Chemistry, 2017, 839, 31
DOI: 10.1016/j.jorganchem.2017.01.016

New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway

Angelica E. Graminha, Cecília Popolin, João Honorato de Araujo-Neto, Rodrigo S. Correa, Kátia M. de Oliveira, Luani R. Godoy, Legna Colina Vegas, Javier Ellena, Alzir A. Batista and Marcia R. Cominetti

European Journal of Medicinal Chemistry, 2022, 243, 114772
DOI: 10.1016/j.ejmech.2022.114772

Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity

Lorenzo Biancalana, Hana Kostrhunova, Lucinda K. Batchelor, Mouna Hadiji, Ilaria Degano, Guido Pampaloni, Stefano Zacchini, Paul J. Dyson, Viktor Brabec and Fabio Marchetti

Inorg. Chem., 2021, 60, 9529
DOI: 10.1021/acs.inorgchem.1c00641

Novel cinnamaldehyde-based aspirin derivatives for the treatment of colorectal cancer

Shan Lu, Obinna N. Obianom and Yong Ai

Bioorganic & Medicinal Chemistry Letters, 2018, 28, 2869
DOI: 10.1016/j.bmcl.2018.07.032

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

Reece G. Kenny and Celine J. Marmion

Chem. Rev., 2019, 119, 1058
DOI: 10.1021/acs.chemrev.8b00271

Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

Ping Jin, Jingwen Jiang, Li Zhou, Zhao Huang, Edouard C. Nice, Canhua Huang and Li Fu

J Hematol Oncol, 2022, 15
DOI: 10.1186/s13045-022-01313-4

Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response

Zuojie Li, Qingpeng Wang, Linming Li, Yan Chen, Jichun Cui, Min Liu, Ning Zhang, Zhifang Liu, Jun Han and Zhengping Wang

J. Med. Chem., 2021, 64, 17920
DOI: 10.1021/acs.jmedchem.1c01236