Mechanism for a molecular assembler of sequence-controlled polymers using parallel DNA and a DNA polymerase

Abstract

Construction of a molecular assembler from DNA that executes a programmed sequence of chemical reactions is a formidable challenge but worthwhile because it would allow assembly and evolution of functional polymers. We present a mechanism using parallel DNA and a DNA polymerase to address two challenges that currently block progress.

Graphical abstract: Mechanism for a molecular assembler of sequence-controlled polymers using parallel DNA and a DNA polymerase

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2025
Accepted
01 Dec 2025
First published
01 Dec 2025
This article is Open Access
Creative Commons BY license

Nanoscale Horiz., 2026, Advance Article

Mechanism for a molecular assembler of sequence-controlled polymers using parallel DNA and a DNA polymerase

J. Bath and A. J. Turberfield, Nanoscale Horiz., 2026, Advance Article , DOI: 10.1039/D5NH00505A

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