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Abstract | Cited by

Analogues of the eukaryotic messenger RNA 5′ end (m7G cap) are useful tools for studying mRNA fate and serve as reagents for in vitro preparation of 5′ capped mRNAs. We designed a biotin-labeled dinucleotide cap analogue that can be incorporated into transcripts to produce 5′-capped and biotinylated mRNAs which retain their biological functionality and may be employed for biotin–(strept)avidin technologies.

Graphical abstract: Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation

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