We developed a CBr4-mediated, sustainable, solvent-free method to synthesize 2-arylimidazo[1,2-a]pyridines from 2-aminopyridines and acetophenones, enabling one-pot, oxidant-free C3 amino-functionalization and C3 bromo-functionalization using K2S2O8.
Herein we disclose the synthesis and an overview of all the functionalization reactions at each carbon atom, viz, C2, C3, C5, C6, C7 and C8 of imidazo[1,2-a]pyridine.
A series of 3-(2,2-dialkyl-2H-chromen-4-yl)-2-phenylimidazo[1,2-a]pyridine derivatives were synthesis. Molecular docking studies and antibacterial evaluation validates as potent druggable antibacterial agents in future.
Application of copper-catalyzed azide–alkyne cycloaddition (CuAAC) “click” reactions assemble bivalent proteolysis-targeting chimeras (PROTACs) constituents targeting tyrosyl-DNA phosphodiesterase 1 (TDP1).
Herein, we present a novel electrochemical approach for the synthesis of N-heterocyclic amides with moderate to excellent yields in batch and flow.