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Abstract
Messenger RNA (mRNA) therapeutics hold significant potential across a wide range of medical applications.
Honglei Zhang, Jingxuan Ma, Teng Ma, Yuqing Ma, Lijie Jin, Lijie Liu, Yangjian Liu, Kai Dong, Man Zhang, Dawei Huang, Fei Yu and Gengshen Song
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GPT-driven generation. Modified ribose synthesis for mRNA cap analogs. Capped mRNA used for vaccines and tumor immunotherapy.
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Abstract
Schematic representation of α-mannose-functionalized poly(β aminoester) nanoparticle administration to mice and their selective targeting to CD209-expressing antigen-presenting cells.
Muattaz Hussain, Ashish Muglikar, Danielle E. Brain, Alexander J. Plant-Hately, Neill J. Liptrott, Daragh M. McLoughlin and Yvonne Perrie
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Abstract
The choice of phospholipid and sterol can significantly influence the performance of lipid nanoparticles in terms of expression, immune responses, and cytokine profiles, highlighting the need for comprehensive lipid composition optimisation.