The past decade has witnessed significant progress in synthesizing structurally diverse and biologically relevant pyrano[2,3-c]pyrazole derivatives through the integration of green methodologies.
Here, we report a simple, efficient, and green protocol for the one-pot synthesis of pyrano[2,3-c]pyrazole derivatives via a sequential three-component strategy using aromatic aldehydes, malononitrile and pyrazolinone in a water–SDS–IL system.
Anchoring of Ni(II) complex onto the surface of mesoporous KIT-6 modified under mild reaction conditions as a highly efficient and reusable nanocatalyst for the synthesis of 5-substituted tetrazoles and pyranopyrazoles.
A novel chemosensor (P1) based on pyranopyrazole has been developed for the specific detection of biothiols. P1 has excellent sensing capability throughout a broad pH range, guaranteeing its adaptability in diverse biological settings.
Magnetic nanoparticle delivery systems are promising for targeted drug delivery, imaging, and chemo-hyperthermia of cancer; but their toxicity from reactive oxygen species generation, targeted delivery, and biodegradation limits their use.