A one-pot multi-component method for pyrimidoazoloazines was developed by the reaction of vicinal amino-nitrile/ester azoloazines with “AcOH–RC(OEt)3–amine”. A plausible mechanism was proposed and cytotoxicity of pyrimidoazoloazines was studied.
An operationally simple one-pot three-component synthesis method for a series of diverse purine analogues of [1,2,4]-triazolo[1,3,5]triazine-2-carboxamide derivatives generated in situ via reaction of 2-hydrazinyl-N-(4-sulfamoylphenyl)-2-thioxoacetamide, cyanoguanidine and a variety of aldehydes.
Facile procedures exploiting three-component reactions were developed to regioselectively obtain 2-amino-7-methyl-5-phenyl- and 2-amino-5-methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine analogues bearing a C-6 electron withdrawing group.
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.
Nano-[CuFe2O4@SiO2/propyl-1-(O-vanillinaldimine)][ZnCl2] was prepared by the placement of Schiff base zinc(II) complex on the magnetite core and used as a reusable catalyst for the synthesis of 5-methyl-N,7-diphenyl-4,7-dihydro-[1,2,4]triazolo[1,5-a] pyrimidine-6-carboxamide derivatives.