Novel triazolo[4,3-b][1,2,4]triazin-7-one derivatives (7a–j) were synthesized and tested against PC3, A549, PACA2 and BJ1 cell lines. 7a and 7g were investigated using DNA fragmentation, DNA damage and gene expression and molecular docking studies.
Through the introduction of trifluoromethyl, dinitromethyl, and/or nitroamino groups onto triazolotriazine, a series of novel fused-ring energetic materials were synthesized.
An operationally simple one-pot three-component synthesis method for a series of diverse purine analogues of [1,2,4]-triazolo[1,3,5]triazine-2-carboxamide derivatives generated in situ via reaction of 2-hydrazinyl-N-(4-sulfamoylphenyl)-2-thioxoacetamide, cyanoguanidine and a variety of aldehydes.
A one-pot multi-component method for pyrimidoazoloazines was developed by the reaction of vicinal amino-nitrile/ester azoloazines with “AcOH–RC(OEt)3–amine”. A plausible mechanism was proposed and cytotoxicity of pyrimidoazoloazines was studied.
Regioselective synthesis and characterization of 6-aroyl-7-aryl-5-methyl-4,7-dihydro [1,2,4]triazolo[1,5-a]pyrimidines identified that compound 5t has the strongest BSA binding via site I static quenching mechanism.