A one-pot multi-component method for pyrimidoazoloazines was developed by the reaction of vicinal amino-nitrile/ester azoloazines with “AcOH–RC(OEt)3–amine”. A plausible mechanism was proposed and cytotoxicity of pyrimidoazoloazines was studied.
Regioselective synthesis and characterization of 6-aroyl-7-aryl-5-methyl-4,7-dihydro [1,2,4]triazolo[1,5-a]pyrimidines identified that compound 5t has the strongest BSA binding via site I static quenching mechanism.
An operationally simple one-pot three-component synthesis method for a series of diverse purine analogues of [1,2,4]-triazolo[1,3,5]triazine-2-carboxamide derivatives generated in situ via reaction of 2-hydrazinyl-N-(4-sulfamoylphenyl)-2-thioxoacetamide, cyanoguanidine and a variety of aldehydes.
Facile procedures exploiting three-component reactions were developed to regioselectively obtain 2-amino-7-methyl-5-phenyl- and 2-amino-5-methyl-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine analogues bearing a C-6 electron withdrawing group.
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.