Photocatalytic cascade cross-dehydrogenative-coupling/cyclization reaction of o-hydroxyarylenaminones with N-arylglycine derivatives for the construction of α-chromone substituted α-amino acid derivatives was developed.
A convenient and efficient method for the synthesis of difluoro/trifluoromethyl carbinol-containing chromone derivatives has been developed.
Di- and monofluorinated 2-hydroxyl chromanones could be achieved selectively through H2O and NFSI fluorinated cyclizations of o-hydroxyarylenaminones, in THF and EtOH.
An unprecedented solvent-tuned electrochemical method for selective C(sp3)–H bond activation towards the synthesis of C3 functionalized chromone derivatives has been developed.
Various fluoroalkyl chromones/chroman-4-ones are synthesized through radical cascade fluoroalkylation/cyclization reactions of o-hydroxyaryl enaminones or 2-(allyloxy)benzaldehydes with fluoroalkyl reagents CF3Br and 1,2-dibromotetrafluoroethane.