Systematic screening of excipients to stabilize aerosolized lipid nanoparticles for enhanced mRNA delivery

Brittany J. Heiser, Mae M. Lewis, Meysam Mohammadi Zerankeshi, Emily K. Netemeyer, Ashlee M. Hernandez, Alexander E. Marras and Debadyuti Ghosh

RSC Pharm., 2025, 2, 1139
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The rise of mRNA therapeutic vaccines

Jinlu Du, Ziling Fan, Jiangming Huang, Zhengyuan Li, Hongguo Hu and Yanxia Li

RSC Pharm., 2025, 2, 235
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Reducing Complexity in Lipid Nanoparticles: Three-Component Zwitterionic Amino Lipids for Targeted Extrahepatic mRNA Delivery

Joshua J. Robinson, Di Zhang, Pratima Basak, Amogh Vaidya, Sumanta Chatterjee, Xiaoyan Bian, Minjeong Kim, Xizhen Lian, Yehui Sun, Erick Guerrero, Xu Wang, Sang M. Lee, Shuai Liu, Junyu Gong, Mayank Tiwari, Godwin K. Babanyinah, Mihaela C. Stefan, Lukas Farbiak and Daniel J. Siegwart

ACS Biomater. Sci. Eng., 2025, 11, 4853
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Manufacturing mRNA-Loaded Lipid Nanoparticles with Precise Size and Morphology Control

Cedric Devos, Aniket Udepurkar, Peter Sagmeister, Ariana S. Hodlewsky, Julie Chen, Andrew Hatas, Nicole Ostrovsky, Mushriq Al-Jazrawe, Joy I. Ren, Andy Y. Liu, Richard D. Braatz and Allan S. Myerson

ACS Nano, 2025, 19, 33991
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Exploring the Challenges of Lipid Nanoparticle Development: The In Vitro–In Vivo Correlation Gap

Sarah Lindsay, Muattaz Hussain, Burcu Binici and Yvonne Perrie

Vaccines, 2025, 13, 339
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Comparative technical and operational assessment of current and emerging bench-scale lipid nanoparticle platforms for production of mRNA vaccines

Changcheng Zhu, Nerie Roa, Estelle Neathery, Nastassia Parker, Jaclyn Delarosa, Scott Knackstedt, Kelly Lee and Manjari Lal

Vaccine: X, 2026, 28, 100771
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Recent advances in engineering approaches for delivery of mRNA-based therapeutics

Ken Ninez Nurpramesti Prinindya, Ghulam Md Ashraf, Shihab Uddin, Elsadig Mahdi and Anwarul Hasan

Biomaterials Advances, 2026, 182, 214667
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Morphological changes induced by buffer exchange during preparation of mRNA-lipid nanoparticles occur in a stepwise manner as pH is elevated

Yujia He, Emily H. Pilkington, Hee Jung Kang, Wye-Khay Fong, Andrew J. Clulow, Angus P.R. Johnston and Colin W. Pouton

Molecular Therapy Methods & Clinical Development, 2025, 33, 101578
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Incorporating immunostimulatory lipids into lipid nanoparticles: exploring expression and immune responses

Maria Evdokimou, Hakam Alaqabani, Muattaz Hussain and Yvonne Perrie

European Journal of Pharmaceutics and Biopharmaceutics, 2026, 223, 115034
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Rapid quality evaluation of lipid nanoparticles using a monolithic HPLC column

Shuhei Murayama, Yukino Innami, Yuki Nakatani, Takashi Takaki, Masatoshi Maeki, Manabu Tokeshi, Nozomi Murayama, Masanori Motokawa, Shota Miyazaki, Eiichi Yamamoto and Masaru Kato

AAPS Open, 2026, 12
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Unlocking the potential of microfluidic assisted formulation of exenatide-loaded solid lipid nanoparticles

Büşra Arpaç Birro, Cristiano Pesce, Francesco Tognetti, Agnese Fragassi, Lisa Casagrande, Mariangela Garofalo, Stefano Salmaso and Paolo Caliceti

International Journal of Pharmaceutics, 2025, 678, 125686
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Structure and Morphology of Lipid Nanoparticles for Nucleic Acid Drug Delivery: A Review

Aniket Udepurkar, Cedric Devos, Peter Sagmeister, Francesco Destro, Pavan Inguva, Soroush Ahmadi, Etienne Boulais, Yufeng Quan, Richard D. Braatz and Allan S. Myerson

ACS Nano, 2025, 19, 21206
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Endogenous targeting lipid nanoparticles for systemic mRNA delivery to lung cancer tumors

Yoon Tae Goo, Vladislav Grigoriev, Tetiana Korzun, Ammar Salem, Kongbrailatpam Shitaljit Sharma, Prem Singh, Chrissa Kioussi, Olena R. Taratula, Daniel L. Marks and Oleh Taratula

Journal of Controlled Release, 2026, 394, 114870
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From in vitro to in vivo: The Dominant role of PEG-Lipids in LNP performance

Ankita Borah, Valeria Giacobbo, Burcu Binici, Ranald Baillie and Yvonne Perrie

European Journal of Pharmaceutics and Biopharmaceutics, 2025, 212, 114726
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Decoding pH‐Driven Phase Transition of Lipid Nanoparticles

Marius F.W. Trollmann and Rainer A. Böckmann

Small, 2026, 22
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Exploring the impact of commonly used ionizable and pegylated lipids on mRNA-LNPs: A combined in vitro and preclinical perspective

Burcu Binici, Zahra Rattray, Assaf Zinger and Yvonne Perrie

Journal of Controlled Release, 2025, 377, 162
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Lipid Nanoparticles for mRNA Delivery in Cancer Immunotherapy

Yasir Alshehry, Xiang Liu, Wenhua Li, Qiyan Wang, Janét Cole and Guizhi Zhu

AAPS J, 2025, 27
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Influence of ionisable lipid and sterol variations on lipid nanoparticle properties and performance

Caitlin McMillan, Amy Druschitz, Stephen Rumbelow, Ankita Borah, Rebecca Macfarlane, Zahra Rattray and Yvonne Perrie

Journal of Controlled Release, 2025, 386, 114056
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The RNA delivery dilemma—lipid versus polymer nanoparticle platforms

Cláudia Martins, Michael J. Mitchell, Dan Peer, Yvonne Perrie, Daniel J. Siegwart, María José Alonso and Juan Aparicio-Blanco

Drug Deliv. and Transl. Res., 2026
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Charge-driven lipid nanoparticle encapsulation of enzymes for enhanced ERT with reduced immunogenicity

Boris Sevarika, Adèle Couvidou, Dana Aldawod, Margarita C. Dinamarca and Scott McNeil

Journal of Controlled Release, 2026, 394, 114859
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A review on RNA technologies renaissance: a paradigm shift shaping the future of modern medicine

Suraj Pratap Singh, Poonam Mundlia, Akanksha Sharma, Harjeet Kaur, Bhawna Chaubey, Akhil Khajuria, Mary Chatterjee, Pradeep Kumar Jaiswal, Pavitra Ranawat, Gurpal Singh and Ravi Pratap Barnwal

Next Bioengineering, 2026, 2, 100016
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Lipid nanoparticle–based mRNA platforms for mucosal HIV vaccines: formulation advances, immune mechanisms, and translational pathways

Narinderjit Singh Sawaran Singh, Ibrahim Saeed Gataa, Luma Hussain Saleh, Subbulakshmi Ganesan, V. Kavitha, Laxmidhar Maharana, Renu Sharma, Mutabar Latipova, Nazira Madatova, Doniyor Jumanazarov and Aseel Smerat

Arch Microbiol, 2026, 208
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Continuous manufacturing of lipid nanoparticles: Influence of device designs and operating parameters

Amol N. Joshi, Sarah Hudson and Vivek V. Ranade

Chemical Engineering Science, 2026, 323, 123140
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Advances in lipid nanoparticle delivery systems for targeted cytokine immunotherapy in autoimmune disorders

Dilpreet Singh

Cytokine, 2026, 198, 157098
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Mind the Age Gap: Expanding the Age Window for mRNA Vaccine Testing in Mice

Muattaz Hussain, Agata Ferguson-Ugorenko, Rebecca Macfarlane, Natalie Orr, Samuel Clarke, Michael J. A. Wilkinson, Linda Horan and Yvonne Perrie

Vaccines, 2025, 13, 370
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Low-Cost Microfluidic Mixers: Are They up to the Task?

Jade Forrester, Callum G. Davidson, May Blair, Lynn Donlon, Daragh M. McLoughlin, Chukwuebuka R. Obiora, Heather Stockdale, Ben Thomas, Martina Nutman, Sarah Brockbank, Zahra Rattray and Yvonne Perrie

Pharmaceutics, 2025, 17, 566
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Accelerating Siloxane-Based Ionizable Lipid Design for LNPs with Data-Efficient Kolmogorov–Arnold Networks

Yujing Zhao, Juntao Wang, Yuxin Song, Qilei Liu and Jiaqi Lin

J. Chem. Inf. Model., 2026, 66, 2140
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