MXenes in healthcare: transformative applications and challenges in medical diagnostics and therapeutics

Keshav Narayan Alagarsamy, Leena Regi Saleth, Kateryna Diedkova, Veronika Zahorodna, Oleksiy Gogotsi, Maksym Pogorielov and Sanjiv Dhingra

Nanoscale, 2025, 17, 11785
DOI: 10.1039/D4NR04853A

MXene-loaded hydrogels for tissue regeneration: a review of recent advances and future perspectives

Satheesh Selvaraj, Rajasekaran Subbarayan, Ankush Chauhan, Majid Jabir and Suresh Ghotekar

J. Mater. Chem. B, 2026, 14, 3972
DOI: 10.1039/D5TB02696B

Quercetin-loaded Ti3C2Tx MXene nanosheets enhance chemo-photothermal therapy in gastric cancer

Jing Liu, Sen Niu, Yufan Sheng, Xiong Zhou, Keming Zhang, Xingqian Hu and Zengyao Li

Materials & Design, 2025, 257, 114392
DOI: 10.1016/j.matdes.2025.114392

Hydrogels and hydrogel-based drug delivery systems for promoting refractory wound healing: Applications and prospects

Xuran Lin, Xinge Zhang, Yuechen Wang, Weiyu Chen, Zhikang Zhu and Shoujie Wang

International Journal of Biological Macromolecules, 2025, 285, 138098
DOI: 10.1016/j.ijbiomac.2024.138098

Two—Dimensional Materials as Antioxidants and Sunscreen Agents in Cosmetics

Xuexue Pan, Rongfei Yu, Jingyi Wu, Jianrong Liang, Weiyuan Huang, Rongyue Huang, Wenkai Li, Yuanlin Xie, Yi Zhao, Yawei Huang, Jiayi Wu, Jinjie Xie, Zhimin Chen, Lu Zhang, Meiyu Wu, Yonggan Fang, Rong Hu and Jianhui Zhang

Braz J Phys, 2025, 55
DOI: 10.1007/s13538-025-01813-x

Photo-controlled spatiotemporal sequential release of MXenes/NO gas from bilayer (clean-cure) hydrogel promotes healing of MRSA biofilm-infected diabetic ulcer wounds

Ying-Tong Ye, Xi Xiao, Hong-Ying Xia, Jie Li, Zhen-Zhen Gong, Ai-Zheng Chen, Shi-Bin Wang and Ranjith Kumar Kankala

Journal of Controlled Release, 2026, 391, 114611
DOI: 10.1016/j.jconrel.2026.114611

MXenes in the application of diabetic foot: mechanisms, therapeutic implications and future perspectives

Zhang Mengru, Wu Qinyi, Yao Zimo, Guo Bingqing, Xia Zhongyu and Jianda Xu

J Mater Sci: Mater Med, 2025, 36
DOI: 10.1007/s10856-025-06895-2

Cascaded, self-decomposing messenger in MXene@Cu-MOF heterostructures for on-demand infection control and pro-angiogenic wound repair

Qianming Li, Jianxiang Zhu, Jiawei Mei, Qiong Li, Fanyu Meng, Xianfei Xie, Lin Tao, Fuqian Lei, Xiangyang Xu, Ming Ni, Quan Liu and Tao Yu

Materials Today Bio, 2026, 36, 102703
DOI: 10.1016/j.mtbio.2025.102703

Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay

Sergiy Kyrylenko, Inna Chorna, Zhanna Klishchova, Ilya Yanko, Anton Roshchupkin, Volodymyr Deineka, Kateryna Diedkova, Anastasia Konieva, Oksana Petrichenko, Irina Kube-Golovin, Gunther Wennemuth, Emerson Coy, Iryna Roslyk, Ivan Baginskiy, Veronika Zahorodna, Oleksiy Gogotsi, Benjamin Chacon, Luciana P. Cartarozzi, Alexandre L. R. Oliveira, Igor Iatsunskyi, Yury Gogotsi and Maksym Pogorielov

ACS Appl. Bio Mater., 2024, 7, 8351
DOI: 10.1021/acsabm.4c01142

Recent Advancements in Inorganic Based Nanomaterials for Wound Healing; Challenges and Future Opportunities

Maryam Aftab, Sobia Mehreen, Muneeb Ullah, Sania Ikram and Muhammad Naeem

J Clust Sci, 2025, 36
DOI: 10.1007/s10876-025-02932-w

Self‐Healing Membranes: Smart Materials for Water Remediation and Desalination

Divya Bajpai Tripathy and Subhalaxmi Pradhan

Water Environment Research, 2025, 97
DOI: 10.1002/wer.70148

Review: biomedical applications of novel MXene nanocomposites

Ashish A. Gawai, Shirish P. Jain, Prawit Nuengmatcha, Minh-Vien Le, Latiful Kabir, Siwaluk Srikrajang, Karna Wijaya and Won-Chun Oh

J Mater Sci, 2025, 60, 23121
DOI: 10.1007/s10853-025-11495-0

Biomaterial-Based Strategies for Infection Control in Chronic Wounds

Maria Pia Ferraz

Applied Sciences, 2026, 16, 3390
DOI: 10.3390/app16073390

Biological and Therapeutic Potentials of MXenes in Tumor Microenvironment-Driven Oncology

Oksana Sulaieva, Nazarii Kobyliak, Ihor Panko, Tetiana Meged, Olena Gaidamak, Maksym Pogorielov and Volodymyr Deineka

ACS Appl. Bio Mater., 2025, 8, 9542
DOI: 10.1021/acsabm.5c00982

Renewable cellulose-reinforced flexible Ti3C2Tx-based phase change composites for electromagnetic shielding and thermal management

Yu Fang, Xianrong Huang, Xiangyu Zhao, Xinpeng Hu, Gangchen Lu, Qi Shi, Jiaxin Ren, Jinping Qu and Xiang Lu

Chemical Engineering Journal, 2025, 525, 170655
DOI: 10.1016/j.cej.2025.170655

A natural polymer-functionalized MXene/ZIF-67 nanocomposite as a synergistic platform for enhanced in vitro cell migration and antibacterial performance

Kasinathan Kasirajan, Marimuthu Karunakaran, Swaminathan Usha, Nagaraj Ganeshwari, V. Raja Preethi and Hong Kyoon Choi

International Journal of Biological Macromolecules, 2025, 322, 146946
DOI: 10.1016/j.ijbiomac.2025.146946

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen and Bo Tao

Advanced Science, 2026
DOI: 10.1002/advs.202521174

The progress of MXene hydrogels fabrication for supercapacitor applications

Mehdi Mehrpooya, Mahdi Eshraghi Eivari, Mohammad Reza Ganjali and Min Hwan Lee

Journal of Power Sources, 2026, 661, 238653
DOI: 10.1016/j.jpowsour.2025.238653

MXene‐Based Functional Platforms for Diabetes Prevention and Treatment

Zixuan Wang, Yuhua Wang, Haijun Zhang, Yumei Wang, Jingwen Liu and Xinghui Liu

Carbon Neutralization, 2026, 5
DOI: 10.1002/cnl2.70130

Great carbon nano materials based composites for electronic skin: Intelligent sensing, and self-powered nano generators

Vineet Kumar, Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal and Sang Shin Park

Nano Energy, 2025, 137, 110805
DOI: 10.1016/j.nanoen.2025.110805

Polymer grafting on MXene as a versatile nanoplatform: Synthesis and applications

Majid Moussaei, Milad Babazadeh-Mamaqani, Hossein Roghani-Mamaqani, Vahid Haddadi-Asl and Hossein Riazi

Coordination Chemistry Reviews, 2025, 544, 216989
DOI: 10.1016/j.ccr.2025.216989

Smart Hydrogels in Wearable Electronics for Wound Treatments

Boyuan Li, Min Li and Yi Wang

Small, 2025, 21
DOI: 10.1002/smll.202507368

Advanced design strategies and multifunctional applications of Nanocellulose/MXene composites: A comprehensive review

Shaowei Wang, Haoyu Ma, Shengbo Ge, Mashallah Rezakazemi and Jingquan Han

Materials Science and Engineering: R: Reports, 2025, 163, 100925
DOI: 10.1016/j.mser.2025.100925

MXene nanomaterials in action: Revolutionizing antibacterial strategies and smart wound healing

Madhu Yadav, Mukesh Kumar, Ashutosh Sharma and Jamilur R. Ansari

Sustainable Materials and Technologies, 2025, 45, e01597
DOI: 10.1016/j.susmat.2025.e01597

Effects of Etching and Delamination on Biocompatibility of Ti-Based MXenes

Kateryna Diedkova, Iryna Roslyk, Nikola Kanas, Lita Grine, Volodymyr Deineka, Agata Blacha-Grzechnik, Martins Boroduskis, Igor Iatsunskyi, Błażej Anastaziak, Anastasia Konieva, Pavlo Shubin, Wojciech Simka, Marks Truhins, Oksana Sulaieva, Ilya Yanko, Veronika Zahorodna, Goran Stojanovic, Oleksiy Gogotsi, Yury Gogotsi and Maksym Pogorielov

ACS Appl. Mater. Interfaces, 2025, 17, 47919
DOI: 10.1021/acsami.5c08807

Mxenes as a versatile nanoplatform: Synthesis and emerging biomedical applications

Ali Mohammad Amani, Ehsan Vafa, Maryam Mirzae, Milad Abbasi, Ahmad Vaez, Atena Najdian, Alireza Jahanbin, Seyed Reza Kasaei, Sareh Mosleh-Shirazi, Hesam Kamyab, Shreeshivadasan Chelliapan, Saravanan Rajendran and Linda P. Guamán

Journal of Industrial and Engineering Chemistry, 2025, 149, 275
DOI: 10.1016/j.jiec.2025.02.020

2D MBene Nanosheets as Sonosensitizers for Ultrasound‐Triggered Precision Cancer Therapy

Lihao Guo, Shuxiang Xu, Xiaolin Tai, Li Wang, Gandong Zhou, Jie Yang, Taorui Yang, Yue Lin, Jianzhi Gao, Minghu Pan, Weiwei Wu and Miaomiao Yuan

Adv Funct Materials, 2026
DOI: 10.1002/adfm.202529462

MXene-Integrated Dual Network Hydrogel Accelerates Radiation-Combined Wound Healing through Modulating Oxidative Stress and Immune Response

Yu Fu, Yuhao Yuan, Chuanjie Zeng, Shuang Lai, Lun Yuan and Yandong Mu

ACS Appl. Mater. Interfaces, 2025, 17, 51671
DOI: 10.1021/acsami.5c10912

A hot-humid tolerant and antibacterial MXene-based hydrogel sensor for real-time cardiorespiratory monitoring in endurance sports

Xiaoyan Wang, Hongcheng Xu, Chuanyu Zhang, Eng G. Lim, Yinchao Zhao, Kai Hoettges, Xueyong Wei, Qifeng Lu, Fuzhou Niu and Pengfei Song

Microsyst Nanoeng, 2025, 11
DOI: 10.1038/s41378-025-01102-2

AI-assisted design and application of wound dressings

Jiekai Guan, Zuhao Li, Huayue Hu, Jiye He, Guiquan Cai and Dongliang Wang

Sensors and Actuators Reports, 2026, 11, 100414
DOI: 10.1016/j.snr.2025.100414

Broccoli-mediated gold nanoparticles: Eco-friendly synthesis and nano-bio interactions promoting wound healing and targeted cytotoxicity

Yasser M. Taay, Mustafa Taha Mohammed, Ali Hussain Alwan and Ahmad Hussein Ismail

Journal of Genetic Engineering and Biotechnology, 2026, 24, 100635
DOI: 10.1016/j.jgeb.2025.100635

One-pot fabrication of cottonseed protein isolate microparticle-embedded carboxymethyl chitosan composite hydrogels

Zhen Zhang, Noureddine Abidi and Damar Lopez-Arredondo

Carbohydrate Polymers, 2025, 370, 124400
DOI: 10.1016/j.carbpol.2025.124400

Nanoscale Engineering of 2D Ti3C2 MXenes with Improved Yield, Oxidation Protection, and Superior Physicochemical Characteristics

Rahul Kumar and Raviraj Vankayala

ACS Appl. Eng. Mater., 2025, 3, 4632
DOI: 10.1021/acsaenm.5c00956

Membrane disruption by Ti₂C quantum dots for highly effective broad-Spectrum antibacterial applications

Danyang Xiao, Yuzhen Zhao, Dejia Hu, Lin Zhao, Jinyun Gou, Zeqiong Li, Bufeng Liang, Chenxu Cao, Dong Wang, Hong Gao and Yan Li

Inorganic Chemistry Communications, 2026, 184, 115918
DOI: 10.1016/j.inoche.2025.115918